ActiQs / Forskning

PUBLIKATIONSREGISTRET

Gå till forskningen.

Publikationsdata från Europe PMC och PubMed. Följ källhänvisningar från ämnesregistret till originalpublikationerna.

Publikationer som ChEBI hänvisar till för ziritaxestat. Visa hela publikationsregistret

En publikationsträff är inte en slutsats. Publikationslistan visar bibliografiska uppgifter. Eventuella forskningsutdrag visas separat med originalunderlag. En källhänvisning visar inte i sig effekt, dosering eller säkerhet.

Publikationer i urvalet

14 träffar

Bibliografisk träff 2023-12-08

Design, synthesis and evaluation of novel UDCA-aminopyrimidine hybrids as ATX inhibitors for the treatment of hepatic and pulmonary fibrosis.

Hu Y, Li L, Tian Y, Xiao Y, Tang J, Zeng S, Zou Z, Shang H.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2023.116029

Bibliografisk träff 2023-08-25

Emerging opportunities to treat idiopathic pulmonary fibrosis: Design, discovery, and optimizations of small-molecule drugs targeting fibrogenic pathways.

Luo W, Gu Y, Fu S, Wang J, Zhang J, Wang Y.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2023.115762

Bibliografisk träff 2023-01-23

"Hit" to lead optimization and chemoinformatic studies for a new series of Autotaxin inhibitors.

Stylianaki EA, Magkrioti C, Ladopoulou EM, Papavasileiou KD, Lagarias P, Melagraki G, Samiotaki M, Panayotou G, Dedos SG, Afantitis A, Aidinis V, Matralis AN.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2023.115130

Bibliografisk träff 2022-04-20

Structure-Based Design of a Novel Class of Autotaxin Inhibitors Based on Endogenous Allosteric Modulators.

Clark JM, Salgado-Polo F, Macdonald SJF, Barrett TN, Perrakis A, Jamieson C.

J Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/acs.jmedchem.2c00368

Bibliografisk träff 2022-03-25

Design, synthesis and promising anti-tumor efficacy of novel imidazo[1,2-a]pyridine derivatives as potent autotaxin allosteric inhibitors.

Lei H, Wang X, Zhao G, Li T, Cui Y, Wu H, Yang J, Jiang N, Zhai X.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2022.114307

Bibliografisk träff 2021-10-30

Structural and PK-guided identification of indole-based non-acidic autotaxin (ATX) inhibitors exhibiting high in vivo anti-fibrosis efficacy in rodent model.

Lei H, Cao Z, Wu H, Li T, Wang X, Chen Y, Ma E, Sun L, Zhai X.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2021.113951

Bibliografisk träff 2021-08-13

Design, synthesis and anti-fibrosis evaluation of imidazo[1,2-a]pyridine derivatives as potent ATX inhibitors.

Chen Y, Lei H, Li T, Cui Y, Wang X, Cao Z, Wu H, Zhai X.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2021.116362

Bibliografisk träff 2020-10-01

Structure-based linker exploration: Discovery of 1-ethyl-1H-indole analogs as novel ATX inhibitors.

Jia F, Lei H, Chen Y, Li T, Xing L, Cao Z, Zhai X.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2020.115795

Bibliografisk träff 2020-07-09

Novel Autotaxin Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis: A Clinical Candidate Discovered Using DNA-Encoded Chemistry.

Cuozzo JW, Clark MA, Keefe AD, Kohlmann A, Mulvihill M, Ni H, Renzetti LM, Resnicow DI, Ruebsam F, Sigel EA, Thomson HA, Wang C, Xie Z, Zhang Y.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.0c00688

Bibliografisk träff 2020-06-12

Discovery of Novel Indole-Based Allosteric Highly Potent ATX Inhibitors with Great <i>In Vivo</i> Efficacy in a Mouse Lung Fibrosis Model.

Lei H, Guo M, Li X, Jia F, Li C, Yang Y, Cao M, Jiang N, Ma E, Zhai X.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.0c00506

Bibliografisk träff 2020-06-01

Structure guided design of potent indole-based ATX inhibitors bearing hydrazone moiety with tumor suppression effects.

Lei H, Li C, Yang Y, Jia F, Guo M, Zhu M, Jiang N, Zhai X.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2020.112456

Bibliografisk träff 2017-05-01

Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis.

Desroy N, Housseman C, Bock X, Joncour A, Bienvenu N, Cherel L, Labeguere V, Rondet E, Peixoto C, Grassot JM, Picolet O, Annoot D, Triballeau N, Monjardet A, Wakselman E, Roncoroni V, Le Tallec S, Blanque R, Cottereaux C, Vandervoort N, Christophe T, Mollat P, Lamers M, Auberval M, Hrvacic B, Ralic J, Oste L, van der Aar E, Brys R, Heckmann B.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.7b00032

Bibliografisk träff 2017-02-10

Highly Potent Non-Carboxylic Acid Autotaxin Inhibitors Reduce Melanoma Metastasis and Chemotherapeutic Resistance of Breast Cancer Stem Cells.

Banerjee S, Norman DD, Lee SC, Parrill AL, Pham TC, Baker DL, Tigyi GJ, Miller DD.

J Med Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.6b01270

Bibliografisk träff 2016-01-28

Development of Autotaxin Inhibitors: An Overview of the Patent and Primary Literature.

Castagna D, Budd DC, Macdonald SJ, Jamieson C, Watson AJ.

J Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1021/acs.jmedchem.5b01599