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Publikationer i urvalet

11 träffar

Bibliografisk träff 2024-01-30

Discovery of benzoheterocyclic-substituted amide derivatives as apoptosis signal-regulating kinase 1 (ASK1) inhibitors.

Tang L, Li M, Bai C, Feng X, Hu H, Yao Y, Li B, Li H, Qin G, Xi N, Lv G, Zhang L, Zhang L.

RSC Med Chem · research-article; journal article · DOI 10.1039/d3md00663h

Bibliografisk träff 2023-10-20

Small-molecule inhibitors targeting apoptosis signal-regulated kinase 1.

Wang T, Pang L, He M, Wang Z.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2023.115889

Bibliografisk träff 2021-04-20

Design, synthesis and biological evaluation of 1H-indazole derivatives as novel ASK1 inhibitors.

Hou S, Yang X, Yang Y, Tong Y, Chen Q, Wan B, Wei R, Lu T, Chen Y, Hu Q.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2021.113482

Bibliografisk träff 2020-12-25

Structure-based discovery of 1H-indole-2-carboxamide derivatives as potent ASK1 inhibitors for potential treatment of ulcerative colitis.

Hou S, Yang X, Tong Y, Yang Y, Chen Q, Wan B, Wei R, Wang Y, Zhang Y, Kong B, Huang J, Chen Y, Lu T, Hu Q, Du D.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2020.113114

Bibliografisk träff 2020-07-12

Structure-guided optimization of a novel class of ASK1 inhibitors with increased sp<sup>3</sup> character and an exquisite selectivity profile.

Bigi-Botterill SV, Ivetac A, Bradshaw EL, Cole D, Dougan DR, Ermolieff J, Halkowycz P, Johnson B, McBride C, Pickens J, Sabat M, Swann S.

Bioorg Med Chem Lett · research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1016/j.bmcl.2020.127405

Bibliografisk träff 2020-04-05

Discovery of a 2-pyridinyl urea-containing compound YD57 as a potent inhibitor of apoptosis signal-regulating kinase 1 (ASK1).

Zhang S, Huang C, Lyu X, Wang P, Zang Y, Wang Z, Wang H, Li J, Zhao Y.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2020.112277

Bibliografisk träff 2020-02-12

Discovery of CNS-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors.

Xin Z, Himmelbauer MK, Jones JH, Enyedy I, Gilfillan R, Hesson T, King K, Marcotte DJ, Murugan P, Santoro JC, Gonzalez-Lopez de Turiso F.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/acsmedchemlett.9b00611

Bibliografisk träff 2019-11-26

Rational Design and Optimization of a Novel Class of Macrocyclic Apoptosis Signal-Regulating Kinase 1 Inhibitors.

Himmelbauer MK, Xin Z, Jones JH, Enyedy I, King K, Marcotte DJ, Murugan P, Santoro JC, Hesson T, Spilker K, Johnson JL, Luzzio MJ, Gilfillan R, de Turiso FG.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.9b01206

Bibliografisk träff 2017-12-13

Discovery of 2-arylquinazoline derivatives as a new class of ASK1 inhibitors.

Monastyrskyi A, Bayle S, Quereda V, Grant W, Cameron M, Duckett D, Roush W.

Bioorg Med Chem Lett · research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2017.12.026

Bibliografisk träff 2017-03-02

Structure-based drug design of novel ASK1 inhibitors using an integrated lead optimization strategy.

Gibson TS, Johnson B, Fanjul A, Halkowycz P, Dougan DR, Cole D, Swann S.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2017.02.079

Bibliografisk träff 2017-02-08

Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure.

Lanier M, Pickens J, Bigi SV, Bradshaw-Pierce EL, Chambers A, Cheruvallath ZS, Cole D, Dougan DR, Ermolieff J, Gibson T, Halkowycz P, Hirokawa A, Ivetac A, Miura J, Nunez E, Sabat M, Tyhonas J, Wang H, Wang X, Swann S.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/acsmedchemlett.6b00481