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Publikationer i urvalet

17 träffar

Bibliografisk träff 2024-03-09

Scaffold hopping derived novel benzoxazepinone receptor-interacting protein kinase 1 (RIP1) inhibitors as anti-necroptosis agents: Anti-inflammatory effect in systemic inflammatory response syndrome (SIRS) and epilepsy.

Jiang R, Xu B, Zhi S, Sun L, Yu B, Huang Q, Shi Y.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2024.116304

Bibliografisk träff 2024-03-01

Design, synthesis and anti-necroptosis activity of fused heterocyclic MLKL inhibitors.

Tang Y, Zhuang C.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2024.117659

Bibliografisk träff 2024-02-24

Small-molecule agents for treating skin diseases.

Cai H, Wen H, Li J, Lu L, Zhao W, Jiang X, Bai R.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2024.116269

Bibliografisk träff 2024-02-03

Design, synthesis and biological evaluation of novel cyclic malonamide derivatives as selective RIPK1 inhibitors.

Petró JL, Bényei G, Bana P, Linke N, Horti F, Szabó JE, Szalai KK, Hornyánszky G, Greiner I, Éles J.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2024.129643

Bibliografisk träff 2024-02-01

Discovery of novel biaryl benzoxazepinones as dual-mode receptor-interacting protein kinase-1 (RIPK1) inhibitors.

Xin Y, Dai P, Shao H, Zhuang C, Li J.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2024.117611

Bibliografisk träff 2023-12-30

From Hit to Lead: Structure-Based Optimization of Novel Selective Inhibitors of Receptor-Interacting Protein Kinase 1 (RIPK1) for the Treatment of Inflammatory Diseases.

Zhang L, Li Y, Tian C, Yang R, Wang Y, Xu H, Zhu Q, Chen S, Li L, Yang S.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.3c02102

Bibliografisk träff 2023-12-27

Discovery of 4-amino-1,6-dihydro-7H-pyrrolo[2,3-d]pyridazin-7-one derivatives as potential receptor-interacting serine/threonine-protein kinase 1 (RIPK1) inhibitors.

Zhang C, Chen Y, Li Y, Shi N, Teng Y, Li N, Tang M, Ma Z, Deng D, Chen L.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2023.116076

Bibliografisk träff 2023-06-20

Scaffold hopping derived novel benzoxazepinone RIPK1 inhibitors as anti-necroptosis agents.

Tang J, Wu Y, Zhao W, Qu Z, Yu J, Wang Z, Shi Y.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2023.117385

Bibliografisk träff 2023-02-01

Structure-Based Design of Novel Alkynyl Thio-Benzoxazepinone Receptor-Interacting Protein Kinase-1 Inhibitors: Extending the Chemical Space from the Allosteric to ATP Binding Pockets.

Quan D, Hou R, Shao H, Zhang X, Yu J, Zhang W, Yuan H, Zhuang C.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.2c02067

Bibliografisk träff 2022-11-08

Small-Molecule Receptor-Interacting Protein 1 (RIP1) Inhibitors as Therapeutic Agents for Multifaceted Diseases: Current Medicinal Chemistry Insights and Emerging Opportunities.

Shi K, Zhang J, Zhou E, Wang J, Wang Y.

J Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1021/acs.jmedchem.2c01518

Bibliografisk träff 2022-10-26

Discovery of a Trifluoromethoxy Cyclopentanone Benzothiazole Receptor-Interacting Protein Kinase 1 Inhibitor as the Treatment for Alzheimer's Disease.

Sun Y, Xu L, Shao H, Quan D, Mo Z, Wang J, Zhang W, Yu J, Zhuang C, Xu K.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.2c01478

Bibliografisk träff 2022-04-03

Investigation on the chemical space of the substituted triazole thio-benzoxazepinone RIPK1 inhibitors.

Hao Y, Shao H, Qu Z, Li J, Shi Y, Zhang W, Yu J, Fu P, Zhuang C.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2022.114345

Bibliografisk träff 2022-02-23

Discovery of novel 2,8-diazaspiro[4.5]decan-1-one derivatives as potent RIPK1 kinase inhibitors.

Niu A, Lin L, Zhang D, Jiang K, Weng D, Zhou W, Wang J.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2022.116686

Bibliografisk träff 2021-04-27

Structure-based bioisosterism design of thio-benzoxazepinones as novel necroptosis inhibitors.

Xia C, Yao Z, Xu L, Zhang W, Chen H, Zhuang C.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2021.113484

Bibliografisk träff 2019-05-09

Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer.

Harris PA, Marinis JM, Lich JD, Berger SB, Chirala A, Cox JA, Eidam PM, Finger JN, Gough PJ, Jeong JU, Kang J, Kasparcova V, Leister LK, Mahajan MK, Miller G, Nagilla R, Ouellette MT, Reilly MA, Rendina AR, Rivera EJ, Sun HH, Thorpe JH, Totoritis RD, Wang W, Wu D, Zhang D, Bertin J, Marquis RW.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/acsmedchemlett.9b00108

Bibliografisk träff 2018-03-06

Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships.

Yoshikawa M, Saitoh M, Katoh T, Seki T, Bigi SV, Shimizu Y, Ishii T, Okai T, Kuno M, Hattori H, Watanabe E, Saikatendu KS, Zou H, Nakakariya M, Tatamiya T, Nakada Y, Yogo T.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.7b01647

Bibliografisk träff 2017-02-10

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases.

Harris PA, Berger SB, Jeong JU, Nagilla R, Bandyopadhyay D, Campobasso N, Capriotti CA, Cox JA, Dare L, Dong X, Eidam PM, Finger JN, Hoffman SJ, Kang J, Kasparcova V, King BW, Lehr R, Lan Y, Leister LK, Lich JD, MacDonald TT, Miller NA, Ouellette MT, Pao CS, Rahman A, Reilly MA, Rendina AR, Rivera EJ, Schaeffer MC, Sehon CA, Singhaus RR, Sun HH, Swift BA, Totoritis RD, Vossenkämper A, Ward P, Wisnoski DD, Zhang D, Marquis RW, Gough PJ, Bertin J.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.6b01751