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Publikationer i urvalet

50 träffar

Bibliografisk träff 2019-07-25

A fragment-like approach to PYCR1 inhibition.

Milne K, Sun J, Zaal EA, Mowat J, Celie PHN, Fish A, Berkers CR, Forlani G, Loayza-Puch F, Jamieson C, Agami R.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2019.07.047

Bibliografisk träff 2019-07-12

Design, synthesis and biological evaluation of hydroxypyridinone-coumarin hybrids as multimodal monoamine oxidase B inhibitors and iron chelates against Alzheimer's disease.

Zhang C, Yang K, Yu S, Su J, Yuan S, Han J, Chen Y, Gu J, Zhou T, Bai R, Xie Y.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2019.07.031

Bibliografisk träff 2019-05-16

Dipropargyl substituted diphenylpyrimidines as dual inhibitors of monoamine oxidase and acetylcholinesterase.

Kumar B, Kumar V, Prashar V, Saini S, Dwivedi AR, Bajaj B, Mehta D, Parkash J, Kumar V.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2019.05.039

Bibliografisk träff 2019-04-02

Discovery, synthesis, biological evaluation and molecular docking study of (R)-5-methylmellein and its analogs as selective monoamine oxidase A inhibitors.

Huang C, Xiong J, Guan HD, Wang CH, Lei X, Hu JF.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2019.03.060

Bibliografisk träff 2019-01-18

Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity.

Baek SC, Kang MG, Park JE, Lee JP, Lee H, Ryu HW, Park CM, Park D, Cho ML, Oh SR, Kim H.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2019.01.016

Bibliografisk träff 2018-09-25

Selected aryl thiosemicarbazones as a new class of multi-targeted monoamine oxidase inhibitors.

Mathew B, Baek SC, Grace Thomas Parambi D, Pil Lee J, Joy M, Annie Rilda PR, Randev RV, Nithyamol P, Vijayan V, Inasu ST, Mathew GE, Lohidakshan KK, Kumar Krishnan G, Kim H.

Medchemcomm · research-article; journal article · DOI 10.1039/c8md00399h

Bibliografisk träff 2018-01-31

Selective inhibition of monoamine oxidase A by hispidol.

Baek SC, Lee HW, Ryu HW, Kang MG, Park D, Kim SH, Cho ML, Oh SR, Kim H.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2018.01.049

Bibliografisk träff 2017-09-27

Design, synthesis, and evaluation of salicyladimine derivatives as multitarget-directed ligands against Alzheimer's disease.

Yang HL, Cai P, Liu QH, Yang XL, Fang SQ, Tang YW, Wang C, Wang XB, Kong LY.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2017.08.048

Bibliografisk träff 2017-08-10

Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease.

Xu YX, Wang H, Li XK, Dong SN, Liu WW, Gong Q, Wang TD, Tang Y, Zhu J, Li J, Zhang HY, Mao F.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2017.08.025

Bibliografisk träff 2017-07-24

Design, synthesis and biological evaluation of novel coumarin-N-benzyl pyridinium hybrids as multi-target agents for the treatment of Alzheimer's disease.

Lan JS, Ding Y, Liu Y, Kang P, Hou JW, Zhang XY, Xie SS, Zhang T.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2017.07.055

Bibliografisk träff 2017-07-08

Design, synthesis and evaluation of coumarin-pargyline hybrids as novel dual inhibitors of monoamine oxidases and amyloid-β aggregation for the treatment of Alzheimer's disease.

Yang HL, Cai P, Liu QH, Yang XL, Li F, Wang J, Wu JJ, Wang XB, Kong LY.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2017.07.008

Bibliografisk träff 2017-05-24

Synthesis and pharmacological evaluation of multi-functional homoisoflavonoid derivatives as potent inhibitors of monoamine oxidase B and cholinesterase for the treatment of Alzheimer's disease.

Liu QH, Wu JJ, Li F, Cai P, Yang XL, Kong LY, Wang XB.

Medchemcomm · research-article; journal article · DOI 10.1039/c7md00199a

Bibliografisk träff 2017-04-22

The evaluation of 1,4-benzoquinones as inhibitors of human monoamine oxidase.

Mostert S, Petzer A, Petzer JP.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2017.04.055

Bibliografisk träff 2016-11-19

N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents.

Košak U, Knez D, Coquelle N, Brus B, Pišlar A, Nachon F, Brazzolotto X, Kos J, Colletier JP, Gobec S.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2016.11.032

Bibliografisk träff 2016-08-22

2-Benzylidene-1-indanone derivatives as inhibitors of monoamine oxidase.

Nel MS, Petzer A, Petzer JP, Legoabe LJ.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2016.08.067

Bibliografisk träff 2016-08-18

Potent selective monoamine oxidase B inhibition by maackiain, a pterocarpan from the roots of Sophora flavescens.

Lee HW, Ryu HW, Kang MG, Park D, Oh SR, Kim H.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2016.08.044

Bibliografisk träff 2016-07-07

Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents.

Pisani L, Farina R, Catto M, Iacobazzi RM, Nicolotti O, Cellamare S, Mangiatordi GF, Denora N, Soto-Otero R, Siragusa L, Altomare CD, Carotti A.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.6b00562

Bibliografisk träff 2016-02-20

Design, synthesis and biological evaluation of novel donepezil-coumarin hybrids as multi-target agents for the treatment of Alzheimer's disease.

Xie SS, Lan JS, Wang X, Wang ZM, Jiang N, Li F, Wu JJ, Wang J, Kong LY.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2016.02.023

Bibliografisk träff 2016-01-16

Inhibition of monoamine oxidase by benzoxathiolone analogues.

Mostert S, Petzer A, Petzer JP.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2016.01.034

Bibliografisk träff 2015-09-25

Monoamine oxidase inhibitory activities of heterocyclic chalcones.

Minders C, Petzer JP, Petzer A, Lourens AC.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2015.09.049

Bibliografisk träff 2015-07-09

Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases.

Farina R, Pisani L, Catto M, Nicolotti O, Gadaleta D, Denora N, Soto-Otero R, Mendez-Alvarez E, Passos CS, Muncipinto G, Altomare CD, Nurisso A, Carrupt PA, Carotti A.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.5b00599

Bibliografisk träff 2015-04-10

Synthesis and evaluation of selegiline derivatives as monoamine oxidase inhibitor, antioxidant and metal chelator against Alzheimer's disease.

Xie S, Chen J, Li X, Su T, Wang Y, Wang Z, Huang L, Li X.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2015.04.009

Bibliografisk träff 2015-03-20

Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease.

Xie SS, Wang X, Jiang N, Yu W, Wang KD, Lan JS, Li ZR, Kong LY.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2015.03.040

Bibliografisk träff 2015-01-03

Reversible and irreversible small molecule inhibitors of monoamine oxidase B (MAO-B) investigated by biophysical techniques.

Rojas RJ, Edmondson DE, Almos T, Scott R, Massari ME.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2014.12.063

Bibliografisk träff 2014-12-19

Multifunctional coumarin derivatives: monoamine oxidase B (MAO-B) inhibition, anti-β-amyloid (Aβ) aggregation and metal chelation properties against Alzheimer's disease.

Huang M, Xie SS, Jiang N, Lan JS, Kong LY, Wang XB.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2014.12.034

Bibliografisk träff 2014-04-16

α-Tetralone derivatives as inhibitors of monoamine oxidase.

Legoabe LJ, Petzer A, Petzer JP.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2014.04.021

Bibliografisk träff 2013-10-01

Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine-Homoisoflavonoid hybrids.

Sun Y, Chen J, Chen X, Huang L, Li X.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2013.09.050

Bibliografisk träff 2013-09-05

Nonpeptidic propargylamines as inhibitors of lysine specific demethylase 1 (LSD1) with cellular activity.

Schmitt ML, Hauser AT, Carlino L, Pippel M, Schulz-Fincke J, Metzger E, Willmann D, Yiu T, Barton M, Schüle R, Sippl W, Jung M.

J Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/jm400792m

Bibliografisk träff 2013-04-04

The opposite effect of isotype-selective monoamine oxidase inhibitors on adipogenesis in human bone marrow mesenchymal stem cells.

Byun Y, Park J, Hong SH, Han MH, Park S, Jung HI, Noh M.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2013.03.117

Bibliografisk träff 2013-02-08

A novel series of tacrine-selegiline hybrids with cholinesterase and monoamine oxidase inhibition activities for the treatment of Alzheimer's disease.

Lu C, Zhou Q, Yan J, Du Z, Huang L, Li X.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2013.01.039