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Publikationer i urvalet

10 träffar

Bibliografisk träff 2021-11-08

Discovery and Optimization of Pyrazole Amides as Inhibitors of ELOVL1.

Come JH, Senter TJ, Clark MP, Court JJ, Gale-Day Z, Gu W, Krueger E, Liang J, Morris M, Nanthakumar S, O'Dowd H, Maltais F, Iyer G, Andreassi J, Boucher C, Considine T, Moody CS, Taylor W, Mohanty AK, Huang Y, Zuccola H, Coll J, Bonanno KC, Gagnon KJ, Gan L, Lu F, Gao H, Chakilam A, Engtrakul J, Song B, Crawford D, Doyle E, Kramer T, Vought B, Phillips J, Kemper R, Sanders M, Swett R, Furey B, Winquist R, Bunnage ME, Jackson KL, Charifson PS, Magavi SS.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.1c00944

Bibliografisk träff 2018-12-04

Structure-Activity Relationships of Central Nervous System Penetration by Fatty Acid Amide Hydrolase (FAAH)-Targeted Thyromimetic Prodrugs.

Meinig JM, Ferrara SJ, Banerji T, Banerji T, Sanford-Crane HS, Bourdette D, Scanlan TS.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/acsmedchemlett.8b00501

Bibliografisk träff 2017-03-23

Ester-to-amide rearrangement of ethanolamine-derived prodrugs of sobetirome with increased blood-brain barrier penetration.

Ferrara SJ, Meinig JM, Placzek AT, Banerji T, McTigue P, Hartley MD, Sanford-Crane HS, Banerji T, Bourdette D, Scanlan TS.

Bioorg Med Chem · research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2017.03.047

Bibliografisk träff 2016-09-16

Sobetirome prodrug esters with enhanced blood-brain barrier permeability.

Placzek AT, Ferrara SJ, Hartley MD, Sanford-Crane HS, Meinig JM, Scanlan TS.

Bioorg Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2016.09.038

Bibliografisk träff 2014-04-08

Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β agonist in clinical trials for the treatment of dyslipidemia.

Kelly MJ, Pietranico-Cole S, Larigan JD, Haynes NE, Reynolds CH, Scott N, Vermeulen J, Dvorozniak M, Conde-Knape K, Huang KS, So SS, Thakkar K, Qian Y, Banner B, Mennona F, Danzi S, Klein I, Taub R, Tilley J.

J Med Chem · journal article · DOI 10.1021/jm4019299

Bibliografisk träff 2013-11-13

Synthesis and pharmacological characterization of 1-benzyl-4-aminoindole-based thyroid hormone receptor β agonists.

Takahashi N, Maeda K, Asano Y, Watanabe N.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2013.11.001

Bibliografisk träff 2012-05-01

Selective thyromimetics using receptor and tissue selectivity approaches: prospects for dyslipidemia.

Joharapurkar AA, Dhote VV, Jain MR.

J Med Chem · review; journal article · DOI 10.1021/jm2004706

Bibliografisk träff 2008-11-01

Synthesis and biological evaluation of a series of liver-selective phosphonic acid thyroid hormone receptor agonists and their prodrugs.

Boyer SH, Jiang H, Jacintho JD, Reddy MV, Li H, Li W, Godwin JL, Schulz WG, Cable EE, Hou J, Wu R, Fujitaki JM, Hecker SJ, Erion MD.

J Med Chem · journal article · DOI 10.1021/jm800824d

Bibliografisk träff 2003-07-01

Structural determinants of selective thyromimetics.

Yoshihara HA, Apriletti JW, Baxter JD, Scanlan TS.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm0301181

Bibliografisk träff 2002-07-01

Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment.

Nguyen NH, Apriletti JW, Cunha Lima ST, Webb P, Baxter JD, Scanlan TS.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm0201013