Potential of covalently linked tamoxifen hybrids for cancer treatment: recent update.
Shagufta, Ahmad I, Nelson DJ, Hussain MI, Nasar NA.
RSC Med Chem · review-article; review; journal article · DOI 10.1039/d3md00632h PUBLIKATIONSREGISTRET
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J Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.8b00035A new Suzuki synthesis of triphenylethylenes that inhibit aromatase and bind to estrogen receptors α and β.
Zhao LM, Jin HS, Liu J, Skaar TC, Ipe J, Lv W, Flockhart DA, Cushman M.
Bioorg Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2016.08.064Recent Progress in the Discovery of Next Generation Inhibitors of Aromatase from the Structure-Function Perspective.
Ghosh D, Lo J, Egbuta C.
J Med Chem · research support, non-u.s. gov't; research-article; review; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.5b01281Synthesis and evaluation of tamoxifen derivatives with a long alkyl side chain as selective estrogen receptor down-regulators.
Shoda T, Kato M, Harada R, Fujisato T, Okuhira K, Demizu Y, Inoue H, Naito M, Kurihara M.
Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2015.05.002Influence of the length and positioning of the antiestrogenic side chain of endoxifen and 4-hydroxytamoxifen on gene activation and growth of estrogen receptor positive cancer cells.
Maximov PY, Fernandes DJ, McDaniel RE, Myers CB, Curpan RF, Jordan VC.
J Med Chem · research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/jm500569hDesign and synthesis of tamoxifen derivatives as a selective estrogen receptor down-regulator.
Shoda T, Okuhira K, Kato M, Demizu Y, Inoue H, Naito M, Kurihara M.
Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2013.11.078Synthesis of mixed (E,Z)-, (E)-, and (Z)-norendoxifen with dual aromatase inhibitory and estrogen receptor modulatory activities.
Lv W, Liu J, Lu D, Flockhart DA, Cushman M.
J Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/jm400364hBioactivation of the cancer chemopreventive agent tamoxifen to quinone methides by cytochrome P4502B6 and identification of the modified residue on the apoprotein.
Sridar C, D'Agostino J, Hollenberg PF.
Drug Metab Dispos · research-article; journal article; research support, n.i.h., extramural · DOI 10.1124/dmd.112.047266Locating the binding sites of anticancer tamoxifen and its metabolites 4-hydroxytamoxifen and endoxifen on bovine serum albumin.
Bourassa P, Dubeau S, Maharvi GM, Fauq AH, Thomas TJ, Tajmir-Riahi HA.
Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2011.07.005Endoxifen, the active metabolite of tamoxifen, is a substrate of the efflux transporter P-glycoprotein (multidrug resistance 1).
Teft WA, Mansell SE, Kim RB.
Drug Metab Dispos · research support, non-u.s. gov't; journal article · DOI 10.1124/dmd.110.036160Structure-function relationships of estrogenic triphenylethylenes related to endoxifen and 4-hydroxytamoxifen.
Maximov PY, Myers CB, Curpan RF, Lewis-Wambi JS, Jordan VC.
J Med Chem · research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/jm901907uEndoxifen is a new potent inhibitor of PKC: a potential therapeutic agent for bipolar disorder.
Ali SM, Ahmad A, Shahabuddin S, Ahmad MU, Sheikh S, Ahmad I.
Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2010.02.024