A Structural Basis for Biguanide Activity.
Gabel SA, Duff MR, Pedersen LC, DeRose EF, Krahn JM, Howell EE, London RE.
Biochemistry · research-article; journal article · DOI 10.1021/acs.biochem.7b00619 PUBLIKATIONSREGISTRET
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Publikationer i urvalet
12 träffarThe metabolic perturbators metformin, phenformin and AICAR interfere with the growth and survival of murine PTEN-deficient T cell lymphomas and human T-ALL/T-LL cancer cells.
Rosilio C, Lounnas N, Nebout M, Imbert V, Hagenbeek T, Spits H, Asnafi V, Pontier-Bres R, Reverso J, Michiels JF, Sahra IB, Bost F, Peyron JF.
Cancer Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.canlet.2013.04.015Phenformin activates the unfolded protein response in an AMP-activated protein kinase (AMPK)-dependent manner.
Yang L, Sha H, Davisson RL, Qi L.
J Biol Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1074/jbc.m113.462762LKB1 mutation sensitizes NSCLC cells to phenformin.
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Cancer Discov · comment; journal article · DOI 10.1158/2159-8290.cd-rw2013-023Evolving therapeutic options for type 2 diabetes mellitus: an overview.
Guthrie RM.
Postgrad Med · research support, non-u.s. gov't; review; journal article · DOI 10.3810/pgm.2012.11.2614Phenformin as prophylaxis and therapy in breast cancer xenografts.
Appleyard MV, Murray KE, Coates PJ, Wullschleger S, Bray SE, Kernohan NM, Fleming S, Alessi DR, Thompson AM.
Br J Cancer · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/bjc.2012.56Metformin and phenformin block the peripheral antinociception induced by diclofenac and indomethacin on the formalin test.
Ortiz MI.
Life Sci · comparative study; journal article · DOI 10.1016/j.lfs.2011.10.009Metformin for aging and cancer prevention.
Anisimov VN.
Aging (Albany NY) · research support, non-u.s. gov't; review-article; review; journal article · DOI 10.18632/aging.100230Phenformin has a direct inhibitory effect on the ATP-sensitive potassium channel.
Aziz Q, Thomas A, Khambra T, Tinker A.
Eur J Pharmacol · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejphar.2010.02.023Hazards posed by a banned drug--phenformin is still hanging around.
Ching CK, Lai CK, Poon WT, Wong EN, Yan WW, Chan AY, Mak TW.
Hong Kong Med J · journal article; case reportsPhenformin-induced lactic acidosis in an older diabetic patient: a recurrent drama (phenformin and lactic acidosis).
Fimognari FL, Pastorelli R, Incalzi RA.
Diabetes Care · letter; case reports · DOI 10.2337/diacare.29.04.06.dc06-0012Effect of treatment with phenformin, diphenylhydantoin or L-dopa on life span and tumour incidence in C3H/Sn mice.
Dilman VM, Anisimov VN.
Gerontology · journal article · DOI 10.1159/000212423