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Publikationer i urvalet

21 träffar

Bibliografisk träff 2020-10-01

A look around the West Indies: The spices of life are secondary metabolites.

Demeritte A, Wuest WM.

Bioorg Med Chem · research-article; review; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2020.115792

Bibliografisk träff 2018-03-09

Improved Dose-Response Relationship of (+)-Discodermolide-Taxol Hybrid Congeners.

Nadaradjane C, Yang CH, Rodriguez-Gabin A, Ye K, Sugasawa K, Atasoylu O, Smith AB, Horwitz SB, McDaid HM.

J Nat Prod · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jnatprod.8b00111

Bibliografisk träff 2017-06-27

Natural alkaloids as P-gp inhibitors for multidrug resistance reversal in cancer.

Joshi P, Vishwakarma RA, Bharate SB.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2017.06.047

Bibliografisk träff 2013-07-23

MT-Stabilizer, Dictyostatin, Exhibits Prolonged Brain Retention and Activity: Potential Therapeutic Implications.

Brunden KR, Gardner NM, James MJ, Yao Y, Trojanowski JQ, Lee VM, Paterson I, Ballatore C, Smith AB.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/ml400233e

Bibliografisk träff 2011-08-26

Design and synthesis of (+)-discodermolide-paclitaxel hybrids leading to enhanced biological activity.

Smith AB, Sugasawa K, Atasoylu O, Yang CP, Horwitz SB.

J Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/jm200692n

Bibliografisk träff 2010-01-01

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Fourches D, Barnes JC, Day NC, Bradley P, Reed JZ, Tropsha A.

Chem Res Toxicol · research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/tx900326k

Bibliografisk träff 2009-10-01

Human liver microsomal metabolism of (+)-discodermolide.

Fan Y, Schreiber EM, Day BW.

J Nat Prod · research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/np900245k

Bibliografisk träff 2008-10-11

Total synthesis and biological evaluation of potent analogues of dictyostatin: modification of the C2-C6 dienoate region.

Paterson I, Gardner NM, Guzmán E, Wright AE.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2008.09.109

Bibliografisk träff 2007-12-15

Synthesis and biological evaluation of 10,11-dihydrodictyostatin, a potent analogue of the marine anticancer agent dictyostatin.

Paterson I, Gardner NM, Poullennec KG, Wright AE.

J Nat Prod · research support, non-u.s. gov't; journal article; research support, n.i.h., extramural · DOI 10.1021/np070547s

Bibliografisk träff 2007-06-02

Total synthesis and biological evaluation of C16 analogs of (-)-dictyostatin.

Jung WH, Harrison C, Shin Y, Fournier JH, Balachandran R, Raccor BS, Sikorski RP, Vogt A, Curran DP, Day BW.

J Med Chem · journal article; research support, n.i.h., extramural · DOI 10.1021/jm061385k

Bibliografisk träff 2007-02-14

Synthesis and biological evaluation of novel analogues of dictyostatin.

Paterson I, Gardner NM, Poullennec KG, Wright AE.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2007.02.031

Bibliografisk träff 2007-01-07

Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites.

Buey RM, Calvo E, Barasoain I, Pineda O, Edler MC, Matesanz R, Cerezo G, Vanderwal CD, Day BW, Sorensen EJ, López JA, Andreu JM, Hamel E, Díaz JF.

Nat Chem Biol · research support, non-u.s. gov't; journal article · DOI 10.1038/nchembio853

Bibliografisk träff 2006-03-01

Synthesis and biological evaluation of purealin and analogues as cytoplasmic dynein heavy chain inhibitors.

Zhu G, Yang F, Balachandran R, Höök P, Vallee RB, Curran DP, Day BW.

J Med Chem · journal article; research support, n.i.h., extramural · DOI 10.1021/jm051030l

Bibliografisk träff 2006-01-18

A series of 23,24-dihydrodiscodermolide analogues with simplified lactone regions.

Shaw SJ, Sundermann KF, Burlingame MA, Zhang D, Petryka J, Myles DC.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2005.12.066

Bibliografisk träff 2005-08-01

Discodermolide analogues as the chemical component of combination bacteriolytic therapy.

Smith AB, Freeze BS, LaMarche MJ, Sager J, Kinzler KW, Vogelstein B.

Bioorg Med Chem Lett · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2005.05.068

Bibliografisk träff 2005-05-01

Design, synthesis and biological evaluation of novel, simplified analogues of laulimalide: modification of the side chain.

Paterson I, Menche D, Håkansson AE, Longstaff A, Wong D, Barasoain I, Buey RM, Díaz JF.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2005.03.018

Bibliografisk träff 2004-05-01

Synthetic analogues of the microtubule-stabilizing agent (+)-discodermolide: preparation and biological activity.

Gunasekera SP, Mickel SJ, Daeffler R, Niederer D, Wright AE, Linley P, Pitts T.

J Nat Prod · journal article · DOI 10.1021/np030493w

Bibliografisk träff 2003-07-01

Simplified discodermolide analogues: synthesis and biological evaluation of 4-epi-7-dehydroxy-14,16-didemethyl-(+)-discodermolides as microtubule-stabilizing agents.

Choy N, Shin Y, Nguyen PQ, Curran DP, Balachandran R, Madiraju C, Day BW.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm0204136

Bibliografisk träff 2002-12-01

Semisynthetic analogues of the microtubule-stabilizing agent discodermolide: preparation and biological activity.

Gunasekera SP, Longley RE, Isbrucker RA.

J Nat Prod · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/np0203234

Bibliografisk träff 2002-11-01

Five new discodermolide analogues from the marine sponge Discodermia species.

Gunasekera SP, Paul GK, Longley RE, Isbrucker RA, Pomponi SA.

J Nat Prod · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/np020219m

Bibliografisk träff 2001-02-01

Acetylated analogues of the microtubule-stabilizing agent discodermolide: preparation and biological activity.

Gunasekera SP, Longley RE, Isbrucker RA.

J Nat Prod · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/np000423e