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Publikationer i urvalet

16 träffar

Bibliografisk träff 2024-01-13

Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel.

Zhang SM, Paulin CBJ, Shu H, Yagüe-Capilla M, Michel M, Marttila P, Ortis F, Bwanika HC, Dirks C, Venkatram RP, Wiita E, Jemth AS, Almlöf I, Loseva O, Hormann FM, Koolmeister T, Linde E, Lee S, Llona-Minguez S, Haraldsson M, Axelsson H, Strömberg K, Homan EJ, Scobie M, Lundbäck T, Helleday T, Rudd SG.

iScience · research-article; journal article · DOI 10.1016/j.isci.2024.108907

Bibliografisk träff 2023-07-19

A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs.

Sutherland JJ, Yonchev D, Fekete A, Urban L.

Nat Commun · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/s41467-023-40064-9

Bibliografisk träff 2016-06-30

Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.

Rana P, Will Y, Nadanaciva S, Jones LH.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2016.06.088

Bibliografisk träff 2016-03-03

DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.

Chen M, Suzuki A, Thakkar S, Yu K, Hu C, Tong W.

Drug Discov Today · review; journal article · DOI 10.1016/j.drudis.2016.02.015

Bibliografisk träff 2014-07-14

Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump.

Aleo MD, Luo Y, Swiss R, Bonin PD, Potter DM, Will Y.

Hepatology · comparative study; journal article · DOI 10.1002/hep.27206

Bibliografisk träff 2013-12-06

A highly predictive 3D-QSAR model for binding to the voltage-gated sodium channel: design of potent new ligands.

Zha C, Brown GB, Brouillette WJ.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2013.11.049

Bibliografisk träff 2012-09-19

Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.

Sakatis MZ, Reese MJ, Harrell AW, Taylor MA, Baines IA, Chen L, Bloomer JC, Yang EY, Ellens HM, Ambroso JL, Lovatt CA, Ayrton AD, Clarke SE.

Chem Res Toxicol · journal article · DOI 10.1021/tx300075j

Bibliografisk träff 2011-12-15

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Liu Z, Shi Q, Ding D, Kelly R, Fang H, Tong W.

PLoS Comput Biol · research support, u.s. gov't, p.h.s.; research-article; journal article · DOI 10.1371/journal.pcbi.1002310

Bibliografisk träff 2011-05-20

FDA-approved drug labeling for the study of drug-induced liver injury.

Chen M, Vijay V, Shi Q, Liu Z, Fang H, Tong W.

Drug Discov Today · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1016/j.drudis.2011.05.007

Bibliografisk träff 2010-01-01

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Fourches D, Barnes JC, Day NC, Bradley P, Reed JZ, Tropsha A.

Chem Res Toxicol · research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/tx900326k

Bibliografisk träff 2008-09-13

Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.

Ahlin G, Karlsson J, Pedersen JM, Gustavsson L, Larsson R, Matsson P, Norinder U, Bergström CA, Artursson P.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm8003152

Bibliografisk träff 2002-07-01

Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3.

Hayer-Zillgen M, Brüss M, Bönisch H.

Br J Pharmacol · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/sj.bjp.0704785

Bibliografisk träff 1994-09-01

(+/-)-Gelliusines A and B, two diastereomeric brominated tris-indole alkaloids from a deep water new caledonian marine sponge (Gellius or Orina sp.).

Bifulco G, Bruno I, Minale L, Riccio R, Calignano A, Debitus C.

J Nat Prod · research support, non-u.s. gov't; journal article · DOI 10.1021/np50111a020

Bibliografisk träff 1986-08-01

4-Amino-6-chloro-2-piperazinopyrimidines with selective affinity for alpha 2-adrenoceptors.

Guérémy C, Audiau F, Renault C, Benavides J, Uzan A, Le Fur G.

J Med Chem · journal article · DOI 10.1021/jm00158a013

Bibliografisk träff 1985-03-01

[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.

McNeal ET, Lewandowski GA, Daly JW, Creveling CR.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00381a019

Bibliografisk träff 1978-11-01

Molecular properties of the adrenergic alpha receptor. 2. Optimum covalent inhibition by two different prototypes of polyamine disulfides.

Melchiorre C, Yong MS, Benfey BG, Belleau B.

J Med Chem · journal article · DOI 10.1021/jm00209a007