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Publikationer i urvalet

12 träffar

Bibliografisk träff 2015-03-17

Tfap2a promotes specification and maturation of neurons in the inner ear through modulation of Bmp, Fgf and notch signaling.

Kantarci H, Edlund RK, Groves AK, Riley BB.

PLoS Genet · research-article; journal article; research support, n.i.h., extramural · DOI 10.1371/journal.pgen.1005037

Bibliografisk träff 2014-05-22

Therapeutic potential of a gamma-secretase inhibitor for hearing restoration in a guinea pig model with noise-induced hearing loss.

Tona Y, Hamaguchi K, Ishikawa M, Miyoshi T, Yamamoto N, Yamahara K, Ito J, Nakagawa T.

BMC Neurosci · research support, non-u.s. gov't; research-article; journal article · DOI 10.1186/1471-2202-15-66

Bibliografisk träff 2013-12-01

Capture and 3D culture of colonic crypts and colonoids in a microarray platform.

Wang Y, Ahmad AA, Shah PK, Sims CE, Magness ST, Allbritton NL.

Lab Chip · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1039/c3lc50813g

Bibliografisk träff 2013-11-05

Lineage-specific expression of bestrophin-2 and bestrophin-4 in human intestinal epithelial cells.

Ito G, Okamoto R, Murano T, Shimizu H, Fujii S, Nakata T, Mizutani T, Yui S, Akiyama-Morio J, Nemoto Y, Okada E, Araki A, Ohtsuka K, Tsuchiya K, Nakamura T, Watanabe M.

PLoS One · research support, non-u.s. gov't; research-article; journal article · DOI 10.1371/journal.pone.0079693

Bibliografisk träff 2013-07-23

Gamma secretase inhibitors of Notch signaling.

Olsauskas-Kuprys R, Zlobin A, Osipo C.

Onco Targets Ther · review-article; journal article · DOI 10.2147/ott.s33766

Bibliografisk träff 2013-01-01

Notch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma.

Mizutari K, Fujioka M, Hosoya M, Bramhall N, Okano HJ, Okano H, Edge AS.

Neuron · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.neuron.2012.10.032

Bibliografisk träff 2012-12-03

The role of γ-secretase activating protein (GSAP) and imatinib in the regulation of γ-secretase activity and amyloid-β generation.

Hussain I, Fabrègue J, Anderes L, Ousson S, Borlat F, Eligert V, Berger S, Dimitrov M, Alattia JR, Fraering PC, Beher D.

J Biol Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1074/jbc.m112.370924

Bibliografisk träff 2012-04-01

pPKCα-mediated effect on in vitro Aβ production in response to gamma secretase inhibitor LY411575 in rat CTXTNA2 astrocytes.

Sozio P, Rapino M, Di Valerio V, Laserra S, Pacella S, Di Stefano A, Cataldi A.

J Biol Regul Homeost Agents · research support, non-u.s. gov't; journal article

Bibliografisk träff 2009-05-06

Existing plaques and neuritic abnormalities in APP:PS1 mice are not affected by administration of the gamma-secretase inhibitor LY-411575.

Garcia-Alloza M, Subramanian M, Thyssen D, Borrelli LA, Fauq A, Das P, Golde TE, Hyman BT, Bacskai BJ.

Mol Neurodegener · research-article; journal article · DOI 10.1186/1750-1326-4-19

Bibliografisk träff 2007-08-30

A multigram chemical synthesis of the gamma-secretase inhibitor LY411575 and its diastereoisomers.

Fauq AH, Simpson K, Maharvi GM, Golde T, Das P.

Bioorg Med Chem Lett · research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2007.07.062

Bibliografisk träff 2005-03-02

Quantitative measurement of changes in amyloid-beta(40) in the rat brain and cerebrospinal fluid following treatment with the gamma-secretase inhibitor LY-411575 [N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide].

Best JD, Jay MT, Otu F, Ma J, Nadin A, Ellis S, Lewis HD, Pattison C, Reilly M, Harrison T, Shearman MS, Williamson TL, Atack JR.

J Pharmacol Exp Ther · comparative study; journal article · DOI 10.1124/jpet.104.081174

Bibliografisk träff 2004-01-12

Studies of Abeta pharmacodynamics in the brain, cerebrospinal fluid, and plasma in young (plaque-free) Tg2576 mice using the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY-411575).

Lanz TA, Hosley JD, Adams WJ, Merchant KM.

J Pharmacol Exp Ther · journal article · DOI 10.1124/jpet.103.060715