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Publikationer i urvalet

12 träffar

Bibliografisk träff 2021-01-25

Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A.

White KM, Rosales R, Yildiz S, Kehrer T, Miorin L, Moreno E, Jangra S, Uccellini MB, Rathnasinghe R, Coughlan L, Martinez-Romero C, Batra J, Rojc A, Bouhaddou M, Fabius JM, Obernier K, Dejosez M, Guillén MJ, Losada A, Avilés P, Schotsaert M, Zwaka T, Vignuzzi M, Shokat KM, Krogan NJ, García-Sastre A.

Science · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1126/science.abf4058

Bibliografisk träff 2015-03-13

Evaluation of plitidepsin in patients with primary myelofibrosis and post polycythemia vera/essential thrombocythemia myelofibrosis: results of preclinical studies and a phase II clinical trial.

Pardanani A, Tefferi A, Guglielmelli P, Bogani C, Bartalucci N, Rodríguez J, Extremera S, Pérez I, Alfaro V, Vannucchi AM.

Blood Cancer J · clinical trial, phase ii; research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/bcj.2015.5

Bibliografisk träff 2015-02-11

Enhanced in vivo therapeutic efficacy of plitidepsin-loaded nanocapsules decorated with a new poly-aminoacid-PEG derivative.

Lollo G, Hervella P, Calvo P, Avilés P, Guillén MJ, Garcia-Fuentes M, Alonso MJ, Torres D.

Int J Pharm · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ijpharm.2015.02.028

Bibliografisk träff 2014-01-27

Trabectedin and plitidepsin: drugs from the sea that strike the tumor microenvironment.

Galmarini CM, D'Incalci M, Allavena P.

Mar Drugs · review-article; review; journal article · DOI 10.3390/md12020719

Bibliografisk träff 2013-11-28

Nano-encapsulation of plitidepsin: in vivo pharmacokinetics, biodistribution, and efficacy in a renal xenograft tumor model.

Oliveira H, Thevenot J, Garanger E, Ibarboure E, Calvo P, Aviles P, Guillen MJ, Lecommandoux S.

Pharm Res · research support, non-u.s. gov't; journal article · DOI 10.1007/s11095-013-1220-3

Bibliografisk träff 2013-05-21

c-Jun N-terminal kinase phosphorylation is a biomarker of plitidepsin activity.

Muñoz-Alonso MJ, Álvarez E, Guillén-Navarro MJ, Pollán M, Avilés P, Galmarini CM, Muñoz A.

Mar Drugs · research support, non-u.s. gov't; research-article; journal article · DOI 10.3390/md11051677

Bibliografisk träff 2012-01-01

Plitidepsin (Aplidin) is a potent inhibitor of diffuse large cell and Burkitt lymphoma and is synergistic with rituximab.

Barboza NM, Medina DJ, Budak-Alpdogan T, Aracil M, Jimeno JM, Bertino JR, Banerjee D.

Cancer Biol Ther · research-article; journal article; research support, n.i.h., extramural · DOI 10.4161/cbt.13.2.18876

Bibliografisk träff 2011-06-09

Plitidepsin has a safe cardiac profile: a comprehensive analysis.

Soto-Matos A, Szyldergemajn S, Extremera S, Miguel-Lillo B, Alfaro V, Coronado C, Lardelli P, Roy E, Corrado CS, Kahatt C.

Mar Drugs · clinical trial, phase ii; research-article; clinical trial, phase i; journal article · DOI 10.3390/md9061007

Bibliografisk träff 2010-04-01

Reports of clinical benefit of plitidepsin (Aplidine), a new marine-derived anticancer agent, in patients with advanced medullary thyroid carcinoma.

Le Tourneau C, Faivre S, Ciruelos E, Domínguez MJ, López-Martín JA, Izquierdo MA, Jimeno J, Raymond E.

Am J Clin Oncol · clinical trial, phase i; journal article · DOI 10.1097/coc.0b013e318199fb6e

Bibliografisk träff 2009-06-01

The mechanism of action of plitidepsin.

Muñoz-Alonso MJ, González-Santiago L, Martínez T, Losada A, Galmarini CM, Muñoz A.

Curr Opin Investig Drugs · review; journal article

Bibliografisk träff 2008-10-22

Population pharmacokinetics meta-analysis of plitidepsin (Aplidin) in cancer subjects.

Nalda-Molina R, Valenzuela B, Ramon-Lopez A, Miguel-Lillo B, Soto-Matos A, Perez-Ruixo JJ.

Cancer Chemother Pharmacol · meta-analysis; journal article · DOI 10.1007/s00280-008-0841-4

Bibliografisk träff 2005-11-01

Plitidepsin has a cytostatic effect in human undifferentiated (anaplastic) thyroid carcinoma.

Bravo SB, García-Rendueles ME, Seoane R, Dosil V, Cameselle-Teijeiro J, López-Lázaro L, Zalvide J, Barreiro F, Pombo CM, Alvarez CV.

Clin Cancer Res · research support, non-u.s. gov't; journal article · DOI 10.1158/1078-0432.ccr-05-0455