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Publikationer i urvalet

11 träffar

Bibliografisk träff 2015-02-12

Protein kinase C inhibitor sotrastaurin in de novo liver transplant recipients: a randomized phase II trial.

Pascher A, De Simone P, Pratschke J, Salamé E, Pirenne J, Isoneimi H, Bijarnia M, Krishnan I, Klupp J.

Am J Transplant · clinical trial, phase ii; research support, non-u.s. gov't; multicenter study; randomized controlled trial; journal article · DOI 10.1111/ajt.13175

Bibliografisk träff 2015-01-28

Docetaxel Facilitates Endothelial Dysfunction through Oxidative Stress via Modulation of Protein Kinase C Beta: The Protective Effects of Sotrastaurin.

Hung CH, Chan SH, Chu PM, Tsai KL.

Toxicol Sci · research support, non-u.s. gov't; research-article; journal article · DOI 10.1093/toxsci/kfv017

Bibliografisk träff 2011-08-30

Sotrastaurin, a protein kinase C inhibitor, ameliorates ischemia and reperfusion injury in rat orthotopic liver transplantation.

Kamo N, Shen XD, Ke B, Busuttil RW, Kupiec-Weglinski JW.

Am J Transplant · research-article; journal article; research support, n.i.h., extramural · DOI 10.1111/j.1600-6143.2011.03700.x

Bibliografisk träff 2011-05-12

Sotrastaurin, a novel small molecule inhibiting protein-kinase C: randomized phase II study in renal transplant recipients.

Friman S, Arns W, Nashan B, Vincenti F, Banas B, Budde K, Cibrik D, Chan L, Klempnauer J, Mulgaonkar S, Nicholson M, Wahlberg J, Wissing KM, Abrams K, Witte S, Woodle ES.

Am J Transplant · multicenter study; randomized controlled trial; journal article · DOI 10.1111/j.1600-6143.2011.03538.x

Bibliografisk träff 2011-02-15

Protein kinase C inhibitor sotrastaurin selectively inhibits the growth of CD79 mutant diffuse large B-cell lymphomas.

Naylor TL, Tang H, Ratsch BA, Enns A, Loo A, Chen L, Lenz P, Waters NJ, Schuler W, Dörken B, Yao YM, Warmuth M, Lenz G, Stegmeier F.

Cancer Res · research support, non-u.s. gov't; journal article · DOI 10.1158/0008-5472.can-10-2525

Bibliografisk träff 2011-02-01

Pharmacokinetics of sotrastaurin combined with tacrolimus or mycophenolic acid in de novo kidney transplant recipients.

Kovarik JM, Steiger JU, Grinyo JM, Rostaing L, Arns W, Dantal J, Proot P, Budde K, Sotrastaurin Renal Transplant Study Group.

Transplantation · clinical trial, phase ii; research support, non-u.s. gov't; multicenter study; randomized controlled trial; journal article · DOI 10.1097/tp.0b013e318203860d

Bibliografisk träff 2010-12-08

Evaluation of the novel protein kinase C inhibitor sotrastaurin as immunosuppressive therapy after renal transplantation.

Matz M, Naik M, Mashreghi MF, Glander P, Neumayer HH, Budde K.

Expert Opin Drug Metab Toxicol · review; journal article · DOI 10.1517/17425255.2011.540238

Bibliografisk träff 2010-10-01

Overview of sotrastaurin clinical pharmacokinetics.

Kovarik JM, Slade A.

Ther Drug Monit · review; journal article · DOI 10.1097/ftd.0b013e3181ee9e26

Bibliografisk träff 2009-12-09

Effects of the novel protein kinase C inhibitor AEB071 (Sotrastaurin) on rat cardiac allograft survival using single agent treatment or combination therapy with cyclosporine, everolimus or FTY720.

Weckbecker G, Pally C, Beerli C, Burkhart C, Wieczorek G, Metzler B, Morris RE, Wagner J, Bruns C.

Transpl Int · research support, non-u.s. gov't; journal article · DOI 10.1111/j.1432-2277.2009.01015.x

Bibliografisk träff 2009-10-01

Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes.

Wagner J, von Matt P, Sedrani R, Albert R, Cooke N, Ehrhardt C, Geiser M, Rummel G, Stark W, Strauss A, Cowan-Jacob SW, Beerli C, Weckbecker G, Evenou JP, Zenke G, Cottens S.

J Med Chem · journal article · DOI 10.1021/jm901108b

Bibliografisk träff 2009-06-02

The potent protein kinase C-selective inhibitor AEB071 (sotrastaurin) represents a new class of immunosuppressive agents affecting early T-cell activation.

Evenou JP, Wagner J, Zenke G, Brinkmann V, Wagner K, Kovarik J, Welzenbach KA, Weitz-Schmidt G, Guntermann C, Towbin H, Cottens S, Kaminski S, Letschka T, Lutz-Nicoladoni C, Gruber T, Hermann-Kleiter N, Thuille N, Baier G.

J Pharmacol Exp Ther · research support, non-u.s. gov't; journal article · DOI 10.1124/jpet.109.153205