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Publikationer i urvalet

14 träffar

Bibliografisk träff 2015-12-28

ATP-site binding inhibitor effectively targets mTORC1 and mTORC2 complexes in glioblastoma.

Neil J, Shannon C, Mohan A, Laurent D, Murali R, Jhanwar-Uniyal M.

Int J Oncol · research support, non-u.s. gov't; journal article · DOI 10.3892/ijo.2015.3311

Bibliografisk träff 2015-12-01

mTOR kinase inhibitor pp242 causes mitophagy terminated by apoptotic cell death in E1A-Ras transformed cells.

Gordeev SA, Bykova TV, Zubova SG, Bystrova OA, Martynova MG, Pospelov VA, Pospelova TV.

Oncotarget · comparative study; research support, non-u.s. gov't; research-article; journal article · DOI 10.18632/oncotarget.6457

Bibliografisk träff 2015-11-06

PP242 suppresses bladder cancer cell proliferation and migration through deactivating the mammalian target of rapamycin complex 2/AKT1 signaling pathway.

Zhang Z, Zhang G, Kong C, Gong D.

Mol Med Rep · research support, non-u.s. gov't; journal article · DOI 10.3892/mmr.2015.4528

Bibliografisk träff 2015-11-02

Combination of cetuximab and PP242 synergistically suppress the progression of wild-type KRAS colorectal carcinoma.

Cheng L, Xia Z, Bian X, Li G, Hu J, Cao Y, Wang Q, Qian X.

Onco Targets Ther · research-article; journal article · DOI 10.2147/ott.s82453

Bibliografisk träff 2015-07-09

Regulation of the epithelial Na+ channel by the mTORC2/SGK1 pathway.

Lang F, Pearce D.

Nephrol Dial Transplant · review-article; review; journal article · DOI 10.1093/ndt/gfv270

Bibliografisk träff 2015-04-01

The antileukemia roles of PP242 alone or in combination with daunorubicin in acute leukemia.

Shi F, Yang X, Gong Y, Shi R, Yang X, Naren D, Wu J.

Anticancer Drugs · research support, non-u.s. gov't; journal article · DOI 10.1097/cad.0000000000000200

Bibliografisk träff 2014-11-21

mTORC2 regulates renal tubule sodium uptake by promoting ENaC activity.

Gleason CE, Frindt G, Cheng CJ, Ng M, Kidwai A, Rashmi P, Lang F, Baum M, Palmer LG, Pearce D.

J Clin Invest · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1172/jci73935

Bibliografisk träff 2014-11-06

The dual mTORC1 and mTORC2 inhibitor PP242 shows strong antitumor activity in a pheochromocytoma PC12 cell tumor model.

Zhang X, Wang X, Qin L, Xu T, Zhu Z, Zhong S, Zhang M, Shen Z.

Urology · journal article · DOI 10.1016/j.urology.2014.09.020

Bibliografisk träff 2014-11-01

PP242 suppresses cell proliferation, metastasis, and angiogenesis of gastric cancer through inhibition of the PI3K/AKT/mTOR pathway.

Xing X, Zhang L, Wen X, Wang X, Cheng X, Du H, Hu Y, Li L, Dong B, Li Z, Ji J.

Anticancer Drugs · research support, non-u.s. gov't; research-article; journal article · DOI 10.1097/cad.0000000000000148

Bibliografisk träff 2014-10-01

PP242 synergizes with suberoylanilide hydroxamic acid to inhibit growth of ovarian cancer cells.

Qin Y, Zhao X, Fang Y.

Int J Gynecol Cancer · research support, non-u.s. gov't; journal article · DOI 10.1097/igc.0000000000000238

Bibliografisk träff 2014-09-19

An mTOR kinase inhibitor slows disease progression in a rat model of polycystic kidney disease.

Ravichandran K, Zafar I, Ozkok A, Edelstein CL.

Nephrol Dial Transplant · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1093/ndt/gfu296

Bibliografisk träff 2013-12-04

Dual mTORC1/2 inhibition in a preclinical xenograft tumor model of endometrial cancer.

Korets SB, Musa F, Curtin J, Blank SV, Schneider RJ.

Gynecol Oncol · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.ygyno.2013.11.027

Bibliografisk träff 2013-05-01

mTOR kinase structure, mechanism and regulation.

Yang H, Rudge DG, Koos JD, Vaidialingam B, Yang HJ, Pavletich NP.

Nature · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/nature12122

Bibliografisk träff 2013-04-01

Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors.

Ducker GS, Atreya CE, Simko JP, Hom YK, Matli MR, Benes CH, Hann B, Nakakura EK, Bergsland EK, Donner DB, Settleman J, Shokat KM, Warren RS.

Oncogene · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/onc.2013.92