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Publikationer i urvalet

14 träffar

Bibliografisk träff 2015-04-09

The heat shock protein 90 inhibitor BIIB021 suppresses the growth of T and natural killer cell lymphomas.

Suzuki M, Takeda T, Nakagawa H, Iwata S, Watanabe T, Siddiquey MN, Goshima F, Murata T, Kawada J, Ito Y, Kojima S, Kimura H.

Front Microbiol · research-article; journal article · DOI 10.3389/fmicb.2015.00280

Bibliografisk träff 2015-03-30

Development of a mitochondria-targeted Hsp90 inhibitor based on the crystal structures of human TRAP1.

Lee C, Park HK, Jeong H, Lim J, Lee AJ, Cheon KY, Kim CS, Thomas AP, Bae B, Kim ND, Kim SH, Suh PG, Ryu JH, Kang BH.

J Am Chem Soc · research support, non-u.s. gov't; journal article · DOI 10.1021/ja511893n

Bibliografisk träff 2014-11-28

Crystallization and preliminary X-ray diffraction analysis of Trap1 complexed with Hsp90 inhibitors.

Jeong H, Kang BH, Lee C.

Acta Crystallogr F Struct Biol Commun · research support, non-u.s. gov't; research-article; journal article · DOI 10.1107/s2053230x14024959

Bibliografisk träff 2014-09-16

BIIB021, a novel Hsp90 inhibitor, sensitizes esophageal squamous cell carcinoma to radiation.

Wang XT, Bao CH, Jia YB, Wang N, Ma W, Liu F, Wang C, Wang JB, Song QX, Cheng YF.

Biochem Biophys Res Commun · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bbrc.2014.09.026

Bibliografisk träff 2014-03-28

BIIB021, an Hsp90 inhibitor, effectively kills a myelodysplastic syndrome cell line via the activation of caspases and inhibition of PI3K/Akt and NF-κB pathway proteins.

Lin S, Li J, Zhou W, Qian W, Wang B, Chen Z.

Exp Ther Med · research-article; journal article · DOI 10.3892/etm.2014.1651

Bibliografisk träff 2013-11-18

Hsp90 inhibitor BIIB021 enhances triptolide-induced apoptosis of human T-cell acute lymphoblastic leukemia cells in vitro mainly by disrupting p53-MDM2 balance.

Li M, Zhang X, Zhou WJ, Chen YH, Liu H, Liu L, Yang CM, Qan WB.

Acta Pharmacol Sin · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/aps.2013.124

Bibliografisk träff 2013-07-23

A purine scaffold HSP90 inhibitor BIIB021 has selective activity against KSHV-associated primary effusion lymphoma and blocks vFLIP K13-induced NF-κB.

Gopalakrishnan R, Matta H, Chaudhary PM.

Clin Cancer Res · research-article; journal article; research support, n.i.h., extramural · DOI 10.1158/1078-0432.ccr-12-3510

Bibliografisk träff 2012-08-31

EC144 is a potent inhibitor of the heat shock protein 90.

Shi J, Van de Water R, Hong K, Lamer RB, Weichert KW, Sandoval CM, Kasibhatla SR, Boehm MF, Chao J, Lundgren K, Timple N, Lough R, Ibanez G, Boykin C, Burrows FJ, Kehry MR, Yun TJ, Harning EK, Ambrose C, Thompson J, Bixler SA, Dunah A, Snodgrass-Belt P, Arndt J, Enyedy IJ, Li P, Hong VS, McKenzie A, Biamonte MA.

J Med Chem · journal article · DOI 10.1021/jm300810x

Bibliografisk träff 2012-08-16

Phase II study of the HSP90-inhibitor BIIB021 in gastrointestinal stromal tumors.

Dickson MA, Okuno SH, Keohan ML, Maki RG, D'Adamo DR, Akhurst TJ, Antonescu CR, Schwartz GK.

Ann Oncol · clinical trial, phase ii; research support, non-u.s. gov't; research-article; randomized controlled trial; journal article · DOI 10.1093/annonc/mds275

Bibliografisk träff 2012-01-04

In vitro metabolism of BIIB021, an inhibitor of heat shock protein 90, in liver microsomes and hepatocytes of rats, dogs, and humans and recombinant human cytochrome P450 isoforms.

Xu L, Woodward C, Khan S, Prakash C.

Drug Metab Dispos · journal article · DOI 10.1124/dmd.111.043000

Bibliografisk träff 2010-03-01

BIIB021, a novel Hsp90 inhibitor, sensitizes head and neck squamous cell carcinoma to radiotherapy.

Yin X, Zhang H, Lundgren K, Wilson L, Burrows F, Shores CG.

Int J Cancer · research support, non-u.s. gov't; journal article · DOI 10.1002/ijc.24815

Bibliografisk träff 2010-03-01

BIIB021, a synthetic Hsp90 inhibitor, has broad application against tumors with acquired multidrug resistance.

Zhang H, Neely L, Lundgren K, Yang YC, Lough R, Timple N, Burrows F.

Int J Cancer · journal article · DOI 10.1002/ijc.24825

Bibliografisk träff 2009-08-11

Heat shock protein 90 inhibitor BIIB021 (CNF2024) depletes NF-kappaB and sensitizes Hodgkin's lymphoma cells for natural killer cell-mediated cytotoxicity.

Böll B, Eltaib F, Reiners KS, von Tresckow B, Tawadros S, Simhadri VR, Burrows FJ, Lundgren K, Hansen HP, Engert A, von Strandmann EP.

Clin Cancer Res · research support, non-u.s. gov't; journal article · DOI 10.1158/1078-0432.ccr-09-0213

Bibliografisk träff 2009-04-01

BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90.

Lundgren K, Zhang H, Brekken J, Huser N, Powell RE, Timple N, Busch DJ, Neely L, Sensintaffar JL, Yang YC, McKenzie A, Friedman J, Scannevin R, Kamal A, Hong K, Kasibhatla SR, Boehm MF, Burrows FJ.

Mol Cancer Ther · journal article · DOI 10.1158/1535-7163.mct-08-0758