Anticancer and radiosensitizing effects of the cyclin-dependent kinase inhibitors, AT7519 and SNS‑032, on cervical cancer.
Kang MA, Kim W, Jo HR, Shin YJ, Kim MH, Jeong JH.
Int J Oncol · comparative study; journal article · DOI 10.3892/ijo.2018.4424 PUBLIKATIONSREGISTRET
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Publikationer i urvalet
6 träffarCyclin-Dependent Kinase Inhibitor AT7519 as a Potential Drug for MYCN-Dependent Neuroblastoma.
Dolman ME, Poon E, Ebus ME, den Hartog IJ, van Noesel CJ, Jamin Y, Hallsworth A, Robinson SP, Petrie K, Sparidans RW, Kok RJ, Versteeg R, Caron HN, Chesler L, Molenaar JJ.
Clin Cancer Res · research support, non-u.s. gov't; research-article; journal article · DOI 10.1158/1078-0432.ccr-15-0313Biased and unbiased strategies to identify biologically active small molecules.
Abet V, Mariani A, Truscott FR, Britton S, Rodriguez R.
Bioorg Med Chem · review; journal article · DOI 10.1016/j.bmc.2014.04.019A phase I pharmacokinetic and pharmacodynamic study of AT7519, a cyclin-dependent kinase inhibitor in patients with refractory solid tumors.
Mahadevan D, Plummer R, Squires MS, Rensvold D, Kurtin S, Pretzinger C, Dragovich T, Adams J, Lock V, Smith DM, Von Hoff D, Calvert H.
Ann Oncol · multicenter study; clinical trial, phase i; journal article · DOI 10.1093/annonc/mdq734AT7519, A novel small molecule multi-cyclin-dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-3beta activation and RNA polymerase II inhibition.
Santo L, Vallet S, Hideshima T, Cirstea D, Ikeda H, Pozzi S, Patel K, Okawa Y, Gorgun G, Perrone G, Calabrese E, Yule M, Squires M, Ladetto M, Boccadoro M, Richardson PG, Munshi NC, Anderson KC, Raje N.
Oncogene · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/onc.2009.510Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines.
Squires MS, Feltell RE, Wallis NG, Lewis EJ, Smith DM, Cross DM, Lyons JF, Thompson NT.
Mol Cancer Ther · journal article · DOI 10.1158/1535-7163.mct-08-0890