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Publikationer som ChEBI hänvisar till för N-methyl-N-[3-[[[2-[(2-oxo-1,3-dihydroindol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]-2-pyridinyl]methanesulfonamide. Visa hela publikationsregistret

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Publikationer i urvalet

15 träffar

Bibliografisk träff 2021-07-29

Identification of Thieno[3,2-<i>d</i>]pyrimidine Derivatives as Dual Inhibitors of Focal Adhesion Kinase and FMS-like Tyrosine Kinase 3.

Cho H, Shin I, Yoon H, Jeon E, Lee J, Kim Y, Ryu S, Song C, Kwon NH, Moon Y, Kim S, Kim ND, Choi HG, Sim T.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.1c00459

Bibliografisk träff 2021-06-25

Synthesis and evaluation of FAK inhibitors with a 5-fluoro-7H-pyrrolo[2,3-d]pyrimidine scaffold as anti-hepatocellular carcinoma agents.

Tan H, Liu Y, Gong C, Zhang J, Huang J, Zhang Q.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2021.113670

Bibliografisk träff 2021-04-12

Progress toward B-Cell Lymphoma 6 BTB Domain Inhibitors for the Treatment of Diffuse Large B-Cell Lymphoma and Beyond.

Ai Y, Hwang L, MacKerell AD, Melnick A, Xue F.

J Med Chem · research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.0c01686

Bibliografisk träff 2021-01-25

Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2.

Berger BT, Amaral M, Kokh DB, Nunes-Alves A, Musil D, Heinrich T, Schröder M, Neil R, Wang J, Navratilova I, Bomke J, Elkins JM, Müller S, Frech M, Wade RC, Knapp S.

Cell Chem Biol · research support, non-u.s. gov't; journal article · DOI 10.1016/j.chembiol.2021.01.003

Bibliografisk träff 2020-10-15

Progress in the Development of Small Molecular Inhibitors of Focal Adhesion Kinase (FAK).

Lu Y, Sun H.

J Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1021/acs.jmedchem.0c01248

Bibliografisk träff 2020-08-09

Design, synthesis and biological evaluation of ring-fused pyrazoloamino pyridine/pyrimidine derivatives as potential FAK inhibitors.

Xie H, Lin X, Zhang Y, Tan F, Chi B, Peng Z, Dong W, An D.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2020.127459

Bibliografisk träff 2019-05-18

Discovery of 2,4-diarylaminopyrimidine derivatives bearing dithiocarbamate moiety as novel FAK inhibitors with antitumor and anti-angiogenesis activities.

Su Y, Li R, Ning X, Lin Z, Zhao X, Zhou J, Liu J, Jin Y, Yin Y.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2019.05.048

Bibliografisk träff 2017-12-01

The target landscape of clinical kinase drugs.

Klaeger S, Heinzlmeir S, Wilhelm M, Polzer H, Vick B, Koenig PA, Reinecke M, Ruprecht B, Petzoldt S, Meng C, Zecha J, Reiter K, Qiao H, Helm D, Koch H, Schoof M, Canevari G, Casale E, Depaolini SR, Feuchtinger A, Wu Z, Schmidt T, Rueckert L, Becker W, Huenges J, Garz AK, Gohlke BO, Zolg DP, Kayser G, Vooder T, Preissner R, Hahne H, Tõnisson N, Kramer K, Götze K, Bassermann F, Schlegl J, Ehrlich HC, Aiche S, Walch A, Greif PA, Schneider S, Felder ER, Ruland J, Médard G, Jeremias I, Spiekermann K, Kuster B.

Science · research support, non-u.s. gov't; research-article; journal article · DOI 10.1126/science.aan4368

Bibliografisk träff 2017-05-11

Discovery of a B-Cell Lymphoma 6 Protein-Protein Interaction Inhibitor by a Biophysics-Driven Fragment-Based Approach.

Kamada Y, Sakai N, Sogabe S, Ida K, Oki H, Sakamoto K, Lane W, Snell G, Iida M, Imaeda Y, Sakamoto J, Matsui J.

J Med Chem · research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/acs.jmedchem.7b00313

Bibliografisk träff 2017-04-05

Indoles as therapeutics of interest in medicinal chemistry: Bird's eye view.

Chadha N, Silakari O.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2017.04.003

Bibliografisk träff 2016-11-02

Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2 potency.

Farand J, Mai N, Chandrasekhar J, Newby ZE, Van Veldhuizen J, Loyer-Drew J, Venkataramani C, Guerrero J, Kwok A, Li N, Zherebina Y, Wilbert S, Zablocki J, Phillips G, Watkins WJ, Mourey R, Notte GT.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2016.10.092

Bibliografisk träff 2013-08-30

Selectivity data: assessment, predictions, concordance, and implications.

Gao C, Cahya S, Nicolaou CA, Wang J, Watson IA, Cummins DJ, Iversen PW, Vieth M.

J Med Chem · journal article · DOI 10.1021/jm400798j

Bibliografisk träff 2013-07-31

Fragment-based discovery of focal adhesion kinase inhibitors.

Grädler U, Bomke J, Musil D, Dresing V, Lehmann M, Hölzemann G, Greiner H, Esdar C, Krier M, Heinrich T.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2013.07.050

Bibliografisk träff 2012-03-27

Mechanism-based inactivation (MBI) of cytochrome P450 enzymes: structure-activity relationships and discovery strategies to mitigate drug-drug interaction risks.

Orr ST, Ripp SL, Ballard TE, Henderson JL, Scott DO, Obach RS, Sun H, Kalgutkar AS.

J Med Chem · review; journal article · DOI 10.1021/jm300065h

Bibliografisk träff 2010-06-01

Emerging targets in osteoporosis disease modification.

Allen JG, Fotsch C, Babij P.

J Med Chem · review; journal article · DOI 10.1021/jm9018756