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Publikationer i urvalet

28 träffar

Bibliografisk träff 2024-06-12

Discovery of new 1,3-diphenylurea appended aryl pyridine derivatives as apoptosis inducers through c-MET and VEGFR-2 inhibition: design, synthesis, <i>in vivo</i> and <i>in silico</i> studies.

Elsebaie HA, Nafie MS, Tawfik HO, Belal A, Ghoneim MM, Obaidullah AJ, Shaaban S, Ayed AA, El-Naggar M, Mehany ABM, Shaldam MA.

RSC Med Chem · research-article; journal article · DOI 10.1039/d4md00280f

Bibliografisk träff 2023-12-30

Structure-activity relationship study of 1,6-naphthyridinone derivatives as selective type II AXL inhibitors with potent antitumor efficacy.

Zhuo L, Guo M, Zhang S, Wu J, Wang M, Shen Y, Peng X, Wang Z, Jiang W, Huang W.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2023.116090

Bibliografisk träff 2023-12-20

Discovery of pyrazolo[3,4-d]pyrimidines as novel mitogen-activated protein kinase kinase 3 (MKK3) inhibitors.

Takarada JE, Cunha MR, Almeida VM, Vasconcelos SNS, Santiago AS, Godoi PH, Salmazo A, Ramos PZ, Fala AM, de Souza LR, Da Silva IEP, Bengtson MH, Massirer KB, Couñago RM.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2023.117561

Bibliografisk träff 2023-10-23

Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors.

Liu J, Zhang X, Chen G, Shao Q, Zou Y, Li Z, Su H, Li M, Xu Y.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2023.115893

Bibliografisk träff 2023-08-11

Discovery of Novel, Thienopyridine-Based Tyrosine Kinase Inhibitors Targeting Tumorigenic RON Splice Variants.

Ryu H, Kim H, Park I, Lee M, Park YS, Jin DH, Hur SC, Park J, Lee H.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/acsmedchemlett.3c00206

Bibliografisk träff 2023-07-23

The mystery of titan hunter: Rationalized striking of the MAPK pathway via Newly synthesized 6-Indolylpyridone-3-Carbonitrile derivatives.

Saleh MM, El-Moselhy T, El-Bastawissy E, Ibrahim MAA, Sayed SRM, Hegazy MF, Efferth T, Jaragh-Alhadad LA, Sidhom PA.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2023.115675

Bibliografisk träff 2023-06-01

Targeting MET: Discovery of Small Molecule Inhibitors as Non-Small Cell Lung Cancer Therapy.

Wang C, Lu X.

J Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1021/acs.jmedchem.3c00028

Bibliografisk träff 2022-06-22

Identification of (S)-1-(2-(2,4-difluorophenyl)-4-oxothiazolidin-3-yl)-3-(4-((7-(3-(4-ethylpiperazin-1-yl)propoxy)-6-methoxyquinolin-4-yl)oxy)-3,5-difluorophenyl)urea as a potential anti-colorectal cancer agent.

Qi B, Wang F, He H, Fan M, Hu L, Xiong L, Gong G, Shi S, Song X.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2022.114561

Bibliografisk träff 2022-03-21

Development of Dual Inhibitors Targeting Epidermal Growth Factor Receptor in Cancer Therapy.

Tan L, Zhang J, Wang Y, Wang X, Wang Y, Zhang Z, Shuai W, Wang G, Chen J, Wang C, Ouyang L, Li W.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.1c01714

Bibliografisk träff 2019-10-24

Synthesis and biological evaluation of new MET inhibitors with 1,6-naphthyridinone scaffold.

Wang MS, Zhuo LS, Yang FP, Wang WJ, Huang W, Yang GF.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2019.111803

Bibliografisk träff 2019-08-02

Structural and Molecular Insight into Resistance Mechanisms of First Generation cMET Inhibitors.

Collie GW, Koh CM, O'Neill DJ, Stubbs CJ, Khurana P, Eddershaw A, Snijder A, Mauritzson F, Barlind L, Dale IL, Shaw J, Phillips C, Hennessy EJ, Cheung T, Narvaez AJ.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/acsmedchemlett.9b00276

Bibliografisk träff 2019-06-15

2,7-naphthyridinone-based MET kinase inhibitors: A promising novel scaffold for antitumor drug development.

Zhuo LS, Xu HC, Wang MS, Zhao XE, Ming ZH, Zhu XL, Huang W, Yang GF.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2019.06.033

Bibliografisk träff 2018-12-04

Targeting the immunity protein kinases for immuno-oncology.

Yuan X, Wu H, Bu H, Zhou J, Zhang H.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2018.11.072

Bibliografisk träff 2018-09-25

Design, synthesis, biological evaluation and cellular imaging of imidazo[4,5-b]pyridine derivatives as potent and selective TAM inhibitors.

Baladi T, Aziz J, Dufour F, Abet V, Stoven V, Radvanyi F, Poyer F, Wu TD, Guerquin-Kern JL, Bernard-Pierrot I, Garrido SM, Piguel S.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2018.09.031

Bibliografisk träff 2017-12-01

The target landscape of clinical kinase drugs.

Klaeger S, Heinzlmeir S, Wilhelm M, Polzer H, Vick B, Koenig PA, Reinecke M, Ruprecht B, Petzoldt S, Meng C, Zecha J, Reiter K, Qiao H, Helm D, Koch H, Schoof M, Canevari G, Casale E, Depaolini SR, Feuchtinger A, Wu Z, Schmidt T, Rueckert L, Becker W, Huenges J, Garz AK, Gohlke BO, Zolg DP, Kayser G, Vooder T, Preissner R, Hahne H, Tõnisson N, Kramer K, Götze K, Bassermann F, Schlegl J, Ehrlich HC, Aiche S, Walch A, Greif PA, Schneider S, Felder ER, Ruland J, Médard G, Jeremias I, Spiekermann K, Kuster B.

Science · research support, non-u.s. gov't; research-article; journal article · DOI 10.1126/science.aan4368

Bibliografisk träff 2017-08-22

Dual MET and SMO Negative Modulators Overcome Resistance to EGFR Inhibitors in Human Nonsmall Cell Lung Cancer.

Morgillo F, Amendola G, Della Corte CM, Giacomelli C, Botta L, Di Maro S, Messere A, Ciaramella V, Taliani S, Marinelli L, Trincavelli ML, Martini C, Novellino E, Ciardiello F, Cosconati S.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.7b00794

Bibliografisk träff 2017-04-05

Synthesis and evaluation of a series of pyridine and pyrimidine derivatives as type II c-Met inhibitors.

Zhao Y, Zhang J, Zhuang R, He R, Xi J, Pan X, Shao Y, Pan J, Sun J, Cai Z, Liu S, Huang W, Lv X.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2017.04.003

Bibliografisk träff 2016-07-30

Design, synthesis and biological evaluation of c-Met kinase inhibitors bearing 2-oxo-1,2-dihydroquinoline scaffold.

Cui H, Peng X, Liu J, Ma C, Ji Y, Zhang W, Geng M, Li Y.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2016.07.077

Bibliografisk träff 2016-07-19

4-Oxo-1,4-dihydroquinoline-3-carboxamide Derivatives as New Axl Kinase Inhibitors.

Tan L, Zhang Z, Gao D, Luo J, Tu ZC, Li Z, Peng L, Ren X, Ding K.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.6b00608

Bibliografisk träff 2015-12-13

Recent advances in the development of dual VEGFR and c-Met small molecule inhibitors as anticancer drugs.

Zhang J, Jiang X, Jiang Y, Guo M, Zhang S, Li J, He J, Liu J, Wang J, Ouyang L.

Eur J Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1016/j.ejmech.2015.12.016

Bibliografisk träff 2015-06-17

Design and biological evaluation of novel 4-(2-fluorophenoxy)quinoline derivatives bearing an imidazolone moiety as c-Met kinase inhibitors.

Liao W, Hu G, Guo Z, Sun D, Zhang L, Bu Y, Li Y, Liu Y, Gong P.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2015.06.026

Bibliografisk träff 2014-04-21

Discovery of novel type II c-Met inhibitors based on BMS-777607.

Zhang W, Ai J, Shi D, Peng X, Ji Y, Liu J, Geng M, Li Y.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2014.04.056

Bibliografisk träff 2014-01-30

Discovery and Biological Evaluation of Novel Dual EGFR/c-Met Inhibitors.

Szokol B, Gyulavári P, Kurkó I, Baska F, Szántai-Kis C, Greff Z, Orfi Z, Peták I, Pénzes K, Torka R, Ullrich A, Orfi L, Vántus T, Kéri G.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/ml4003309

Bibliografisk träff 2013-10-22

New aminopyrimidine derivatives as inhibitors of the TAM family.

Traoré T, Cavagnino A, Saettel N, Radvanyi F, Piguel S, Bernard-Pierrot I, Stoven V, Legraverend M.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2013.10.037

Bibliografisk träff 2013-03-06

Small-molecule inhibitor BMS-777607 induces breast cancer cell polyploidy with increased resistance to cytotoxic chemotherapy agents.

Sharma S, Zeng JY, Zhuang CM, Zhou YQ, Yao HP, Hu X, Zhang R, Wang MH.

Mol Cancer Ther · research support, non-u.s. gov't; journal article; research support, n.i.h., extramural · DOI 10.1158/1535-7163.mct-12-1079

Bibliografisk träff 2011-12-01

Design, Synthesis and Biological Evaluation of a Series of Novel Axl Kinase Inhibitors.

Mollard A, Warner SL, Call LT, Wade ML, Bearss JJ, Verma A, Sharma S, Vankayalapati H, Bearss DJ.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/ml200198x

Bibliografisk träff 2011-05-25

Combined SVM-based and docking-based virtual screening for retrieving novel inhibitors of c-Met.

Xie QQ, Zhong L, Pan YL, Wang XY, Zhou JP, Di-Wu L, Huang Q, Wang YL, Yang LL, Xie HZ, Yang SY.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2011.05.031

Bibliografisk träff 2009-03-01

Discovery of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a selective and orally efficacious inhibitor of the Met kinase superfamily.

Schroeder GM, An Y, Cai ZW, Chen XT, Clark C, Cornelius LA, Dai J, Gullo-Brown J, Gupta A, Henley B, Hunt JT, Jeyaseelan R, Kamath A, Kim K, Lippy J, Lombardo LJ, Manne V, Oppenheimer S, Sack JS, Schmidt RJ, Shen G, Stefanski K, Tokarski JS, Trainor GL, Wautlet BS, Wei D, Williams DK, Zhang Y, Zhang Y, Fargnoli J, Borzilleri RM.

J Med Chem · journal article · DOI 10.1021/jm801586s