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Publikationer som ChEBI hänvisar till för 6-chloro-7-[2-(4-morpholinyl)ethylamino]quinoline-5,8-dione. Visa hela publikationsregistret

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Publikationer i urvalet

15 träffar

Bibliografisk träff 2023-12-24

Scaffold Hopping and Structural Modification of NSC 663284: Discovery of Potent (Non)Halogenated Aminobenzoquinones.

Bayrak N, Sever B, Ciftci H, Otsuka M, Fujita M, TuYuN AF.

Biomedicines · research-article; journal article · DOI 10.3390/biomedicines12010050

Bibliografisk träff 2023-06-02

6-Regioisomeric 5,8-quinolinediones as potent CDC25 inhibitors against colorectal cancers.

Narwanti I, Yu ZY, Sethy B, Lai MJ, Lee HY, Olena P, Lee SB, Liou JP.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2023.115505

Bibliografisk träff 2023-01-15

Structural Modification and Pharmacological Evaluation of Substituted Quinoline-5,8-diones as Potent NSD2 Inhibitors.

Tang H, Yu A, Xing L, Chen X, Ding H, Yang H, Song Z, Shi Q, Geng M, Huang X, Zhang A.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.2c01920

Bibliografisk träff 2021-08-09

Discovery of potent and selective Cdc25 phosphatase inhibitors via rapid assembly and in situ screening of Quinonoid-focused libraries.

Tao Y, Hao X, Jing L, Sun L, Cherukupalli S, Liu S, Wu G, Xu S, Zhang X, Shi X, Song Y, Liu X, Zhan P.

Bioorg Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bioorg.2021.105254

Bibliografisk träff 2019-09-14

Identification of highly potent and selective Cdc25 protein phosphatases inhibitors from miniaturization click-chemistry-based combinatorial libraries.

Jing L, Wu G, Hao X, Olotu FA, Kang D, Chen CH, Lee KH, Soliman MES, Liu X, Song Y, Zhan P.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2019.111696

Bibliografisk träff 2017-11-27

Live Fluorescent Staining Platform for Drug-Screening and Mechanism-Analysis in Zebrafish for Bone Mineralization.

Chen JR, Lai YH, Tsai JJ, Hsiao CD.

Molecules · research-article; journal article · DOI 10.3390/molecules22122068

Bibliografisk träff 2017-10-09

Identification of the quinolinedione inhibitor binding site in Cdc25 phosphatase B through docking and molecular dynamics simulations.

Ge Y, van der Kamp M, Malaisree M, Liu D, Liu Y, Mulholland AJ.

J Comput Aided Mol Des · journal article · DOI 10.1007/s10822-017-0073-y

Bibliografisk träff 2008-08-01

Development of a 384-well colorimetric assay to quantify hydrogen peroxide generated by the redox cycling of compounds in the presence of reducing agents.

Johnston PA, Soares KM, Shinde SN, Foster CA, Shun TY, Takyi HK, Wipf P, Lazo JS.

Assay Drug Dev Technol · research-article; journal article; research support, n.i.h., extramural · DOI 10.1089/adt.2008.151

Bibliografisk träff 2008-02-01

A cell-active inhibitor of mitogen-activated protein kinase phosphatases restores paclitaxel-induced apoptosis in dexamethasone-protected cancer cells.

Vogt A, McDonald PR, Tamewitz A, Sikorski RP, Wipf P, Skoko JJ, Lazo JS.

Mol Cancer Ther · research support, non-u.s. gov't; journal article; research support, n.i.h., extramural · DOI 10.1158/1535-7163.mct-07-2165

Bibliografisk träff 2007-09-01

Pharmacology and antitumor activity of a quinolinedione Cdc25 phosphatase inhibitor DA3003-1 (NSC 663284).

Guo J, Parise RA, Joseph E, Lan J, Pan SS, Joo B, Egorin MJ, Wipf P, Lazo JS, Eiseman JL.

Anticancer Res · research support, non-u.s. gov't; journal article; research support, n.i.h., extramural

Bibliografisk träff 2005-09-09

Redox regulation of Cdc25B by cell-active quinolinediones.

Brisson M, Nguyen T, Wipf P, Joo B, Day BW, Skoko JS, Schreiber EM, Foster C, Bansal P, Lazo JS.

Mol Pharmacol · research support, non-u.s. gov't; journal article; research support, n.i.h., extramural · DOI 10.1124/mol.105.016360

Bibliografisk träff 2004-02-26

Down-regulation of survivin in nitric oxide-induced cell growth inhibition and apoptosis of the human lung carcinoma cells.

Chao JI, Kuo PC, Hsu TS.

J Biol Chem · research support, non-u.s. gov't; journal article · DOI 10.1074/jbc.m312381200

Bibliografisk träff 2004-01-12

NAD(P)H:quinone oxidoreductase-1-dependent and -independent cytotoxicity of potent quinone Cdc25 phosphatase inhibitors.

Han Y, Shen H, Carr BI, Wipf P, Lazo JS, Pan SS.

J Pharmacol Exp Ther · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1124/jpet.103.059477

Bibliografisk träff 2002-09-27

Dual G1 and G2 phase inhibition by a novel, selective Cdc25 inhibitor 6-chloro-7-[corrected](2-morpholin-4-ylethylamino)-quinoline-5,8-dione.

Pu L, Amoscato AA, Bier ME, Lazo JS.

J Biol Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1074/jbc.m207902200

Bibliografisk träff 2001-11-01

Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25.

Lazo JS, Aslan DC, Southwick EC, Cooley KA, Ducruet AP, Joo B, Vogt A, Wipf P.

J Med Chem · research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/jm0102046