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Publikationer i urvalet

30 träffar

Bibliografisk träff 2024-01-13

Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel.

Zhang SM, Paulin CBJ, Shu H, Yagüe-Capilla M, Michel M, Marttila P, Ortis F, Bwanika HC, Dirks C, Venkatram RP, Wiita E, Jemth AS, Almlöf I, Loseva O, Hormann FM, Koolmeister T, Linde E, Lee S, Llona-Minguez S, Haraldsson M, Axelsson H, Strömberg K, Homan EJ, Scobie M, Lundbäck T, Helleday T, Rudd SG.

iScience · research-article; journal article · DOI 10.1016/j.isci.2024.108907

Bibliografisk träff 2020-01-06

Structure-Functional-Selectivity Relationship Studies of Novel Apomorphine Analogs to Develop D1R/D2R Biased Ligands.

Park H, Urs AN, Zimmerman J, Liu C, Wang Q, Urs NM.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/acsmedchemlett.9b00575

Bibliografisk träff 2017-06-21

Influence of the cellular environment on ligand binding kinetics at membrane-bound targets.

Vanderheyden PML, Benachour N.

Bioorg Med Chem Lett · research support, non-u.s. gov't; review; journal article · DOI 10.1016/j.bmcl.2017.06.051

Bibliografisk träff 2016-08-10

Highly Selective Dopamine D3 Receptor (D3R) Antagonists and Partial Agonists Based on Eticlopride and the D3R Crystal Structure: New Leads for Opioid Dependence Treatment.

Kumar V, Bonifazi A, Ellenberger MP, Keck TM, Pommier E, Rais R, Slusher BS, Gardner E, You ZB, Xi ZX, Newman AH.

J Med Chem · research-article; journal article · DOI 10.1021/acs.jmedchem.6b00860

Bibliografisk träff 2015-06-20

Bifunctional compounds targeting both D2 and non-α7 nACh receptors: design, synthesis and pharmacological characterization.

Matera C, Pucci L, Fiorentini C, Fucile S, Missale C, Grazioso G, Clementi F, Zoli M, De Amici M, Gotti C, Dallanoce C.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2015.06.039

Bibliografisk träff 2014-06-03

Tranylcypromine substituted cis-hydroxycyclobutylnaphthamides as potent and selective dopamine D₃ receptor antagonists.

Chen J, Levant B, Jiang C, Keck TM, Newman AH, Wang S.

J Med Chem · research support, n.i.h., intramural; rapid-communication; journal article; research support, n.i.h., extramural · DOI 10.1021/jm401798r

Bibliografisk träff 2014-05-08

Shuttle-cargo fusion molecules of transport peptides and the hD2/3 receptor antagonist fallypride: a feasible approach to preserve ligand-receptor binding?

Wängler C, Chowdhury S, Höfner G, Djurova P, Purisima EO, Bartenstein P, Wängler B, Fricker G, Wanner KT, Schirrmacher R.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm5004123

Bibliografisk träff 2013-02-01

Lysosomal sequestration (trapping) of lipophilic amine (cationic amphiphilic) drugs in immortalized human hepatocytes (Fa2N-4 cells).

Kazmi F, Hensley T, Pope C, Funk RS, Loewen GJ, Buckley DB, Parkinson A.

Drug Metab Dispos · research-article; journal article; research support, n.i.h., extramural · DOI 10.1124/dmd.112.050054

Bibliografisk träff 2012-11-15

Discovery of novel α₁-adrenoceptor ligands based on the antipsychotic sertindole suitable for labeling as PET ligands.

Jørgensen M, Jørgensen PN, Christoffersen CT, Jensen KG, Balle T, Bang-Andersen B.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2012.10.049

Bibliografisk träff 2011-03-12

QSAR-based permeability model for drug-like compounds.

Gozalbes R, Jacewicz M, Annand R, Tsaioun K, Pineda-Lucena A.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2011.03.011

Bibliografisk träff 2010-10-01

Exploring the neuroleptic substituent in octoclothepin: potential ligands for positron emission tomography with subnanomolar affinity for α(1)-adrenoceptors.

Kristensen JL, Püschl A, Jensen M, Risgaard R, Christoffersen CT, Bang-Andersen B, Balle T.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm100652h

Bibliografisk träff 2007-08-19

In vitro affinities of various halogenated benzamide derivatives as potential radioligands for non-invasive quantification of D(2)-like dopamine receptors.

Stark D, Piel M, Hübner H, Gmeiner P, Gründer G, Rösch F.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2007.07.017

Bibliografisk träff 2004-08-01

[Drug-induced liver injury; fourteenth updated edition of the bibliographic database of liver injuries and related drugs].

Biour M, Ben Salem C, Chazouillères O, Grangé JD, Serfaty L, Poupon R.

Gastroenterol Clin Biol · bibliography; journal article · DOI 10.1016/s0399-8320(04)95062-2

Bibliografisk träff 2003-11-01

Synthesis and affinity of a possible byproduct of electrophilic radiolabeling of [123I]IBZM.

Baldwin RM, Fu X, Kula NS, Baldessarini RJ, Amici L, Innis RB, Tamagnan GD.

Bioorg Med Chem Lett · research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1016/j.bmcl.2003.08.063

Bibliografisk träff 2003-10-01

Molecular modeling of the three-dimensional structure of dopamine 3 (D3) subtype receptor: discovery of novel and potent D3 ligands through a hybrid pharmacophore- and structure-based database searching approach.

Varady J, Wu X, Fang X, Min J, Hu Z, Levant B, Wang S.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm030085p

Bibliografisk träff 2002-10-01

Synthesis and pharmacological evaluation of 1-[(1,2-diphenyl-1H-4-imidazolyl)methyl]-4-phenylpiperazines with clozapine-like mixed activities at dopamine D(2), serotonin, and GABA(A) receptors.

Asproni B, Pau A, Bitti M, Melosu M, Cerri R, Dazzi L, Seu E, Maciocco E, Sanna E, Busonero F, Talani G, Pusceddu L, Altomare C, Trapani G, Biggio G.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm020848t

Bibliografisk träff 2000-06-01

QSAR model for drug human oral bioavailability.

Yoshida F, Topliss JG.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm0000564

Bibliografisk träff 1993-05-01

Synthesis of (R,S)-2'-trans-7-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'- propenyl)-amino]tetralin (trans-7-OH-PIPAT): a new D3 dopamine receptor ligand.

Foulon C, Kung MP, Kung HF.

J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00062a025

Bibliografisk träff 1993-01-01

Fluorinated and iodinated dopamine agents: D2 imaging agents for PET and SPECT.

Chumpradit S, Kung MP, Billings J, Mach R, Kung HF.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00054a005

Bibliografisk träff 1993-01-01

Effects of solvation on the ionization and conformation of raclopride and other antidopaminergic 6-methoxysalicylamides: insight into the pharmacophore.

Tsai RS, Carrupt PA, Testa B, Gaillard P, el Tayar N, Högberg T.

J Med Chem · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00054a002

Bibliografisk träff 1992-06-01

Conformational analysis of dopamine D-2 receptor antagonists of the benzamide series in relation to a recently proposed D-2 receptor-interaction model.

Pettersson I, Liljefors T.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00091a002

Bibliografisk träff 1991-05-01

Synthesis and in vitro evaluation of 2,3-dimethoxy-5-(fluoroalkyl)-substituted benzamides: high-affinity ligands for CNS dopamine D2 receptors.

Bishop JE, Mathis CA, Gerdes JM, Whitney JM, Eaton AM, Mailman RB.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/jm00109a013

Bibliografisk träff 1991-03-01

Potential antipsychotic agents. 9. Synthesis and stereoselective dopamine D-2 receptor blockade of a potent class of substituted (R)-N-[(1-benzyl-2-pyrrolidinyl)methyl]benzamides. Relations to other side chain congeners.

Högberg T, Ström P, de Paulis T, Stensland B, Csöregh I, Lundin K, Hall H, Ogren SO.

J Med Chem · comparative study; journal article · DOI 10.1021/jm00107a012

Bibliografisk träff 1990-09-01

N-fluoroalkylated and N-alkylated analogues of the dopaminergic D-2 receptor antagonist raclopride.

Lannoye GS, Moerlein SM, Parkinson D, Welch MJ.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00171a017

Bibliografisk träff 1990-08-01

Potential antipsychotic agents. 7. Synthesis and antidopaminergic properties of the atypical highly potent (S)-5-bromo-2,3-dimethoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]benzamide and related compounds. A comparative study.

Högberg T, de Paulis T, Johansson L, Kumar Y, Hall H, Ogren SO.

J Med Chem · comparative study; journal article · DOI 10.1021/jm00170a040

Bibliografisk träff 1990-04-01

Potential antipsychotic agents 5. Synthesis and antidopaminergic properties of substituted 5,6-dimethoxysalicylamides and related compounds.

Högberg T, Bengtsson S, de Paulis T, Johansson L, Ström P, Hall H, Ogren SO.

J Med Chem · journal article · DOI 10.1021/jm00166a012

Bibliografisk träff 1990-01-01

Synthesis and characterization of iodobenzamide analogues: potential D-2 dopamine receptor imaging agents.

Murphy RA, Kung HF, Kung MP, Billings J.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00163a029

Bibliografisk träff 1988-10-01

(S)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-[125I]iodo- 2-methoxybenzamide hydrochloride, a new selective radioligand for dopamine D-2 receptors.

de Paulis T, Janowsky A, Kessler RM, Clanton JA, Smith HE.

J Med Chem · journal article · DOI 10.1021/jm00118a031

Bibliografisk träff 1988-05-01

Dopamine D-2 receptor imaging radiopharmaceuticals: synthesis, radiolabeling, and in vitro binding of (R)-(+)- and (S)-(-)-3-iodo-2-hydroxy-6-methoxy-N- [(1-ethyl-2-pyrrolidinyl)methyl]benzamide.

Kung HF, Kasliwal R, Pan SG, Kung MP, Mach RH, Guo YZ.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00400a027

Bibliografisk träff 1986-01-01

Potential neuroleptic agents. 4. Chemistry, behavioral pharmacology, and inhibition of [3H]spiperone binding of 3,5-disubstituted N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-methoxysalicylamides.

de Paulis T, Kumar Y, Johansson L, Rämsby S, Hall H, Sällemark M, Angeby-Möller K, Ogren SO.

J Med Chem · comparative study; journal article · DOI 10.1021/jm00151a010