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Publikationer i urvalet

26 träffar

Bibliografisk träff 2024-02-20

Development of an UPLC-MS/MS method for quantitative analysis of abexinostat levels in rat plasma and application of pharmacokinetics.

Yu Y, Hu J, Chen X, Wu HL, Wang A, Tang C.

BMC Chem · research-article; journal article · DOI 10.1186/s13065-024-01144-z

Bibliografisk träff 2021-10-25

Differential gene expression-based connectivity mapping identified novel drug candidate and improved Temozolomide efficacy for Glioblastoma.

Vengoji R, Atri P, Macha MA, Seshacharyulu P, Perumal N, Mallya K, Liu Y, Smith LM, Rachagani S, Mahapatra S, Ponnusamy MP, Jain M, Batra SK, Shonka N.

J Exp Clin Cancer Res · research-article; journal article · DOI 10.1186/s13046-021-02135-x

Bibliografisk träff 2021-01-01

The histone deacetylase inhibitor PCI-24781 impairs calcium influx and inhibits proliferation and metastasis in breast cancer.

Yang T, Wang P, Yin X, Zhang J, Huo M, Gao J, Li G, Teng X, Yu H, Huang W, Wang Y.

Theranostics · research support, non-u.s. gov't; research-article; journal article · DOI 10.7150/thno.48314

Bibliografisk träff 2020-06-10

Increasing CRISPR/Cas9-mediated homology-directed DNA repair by histone deacetylase inhibitors.

Li G, Zhang X, Wang H, Liu D, Li Z, Wu Z, Yang H.

Int J Biochem Cell Biol · research support, non-u.s. gov't; journal article · DOI 10.1016/j.biocel.2020.105790

Bibliografisk träff 2017-01-25

Time dependent modulation of tumor radiosensitivity by a pan HDAC inhibitor: abexinostat.

Rivera S, Leteur C, Mégnin F, Law F, Martins I, Kloos I, Depil S, Modjtahedi N, Perfettini JL, Hennequin C, Deutsch E.

Oncotarget · research-article; journal article · DOI 10.18632/oncotarget.14813

Bibliografisk träff 2016-06-06

PCI-24781 can improve in vitro and in vivo developmental capacity of pig somatic cell nuclear transfer embryos.

Jin L, Zhu HY, Guo Q, Li XC, Zhang YC, Zhang GL, Xing XX, Xuan MF, Luo QR, Yin XJ, Kang JD.

Biotechnol Lett · journal article · DOI 10.1007/s10529-016-2141-0

Bibliografisk träff 2016-04-18

The histone deacetylase inhibitor PCI-24781 as a putative radiosensitizer in pediatric glioblastoma cell lines.

de Andrade PV, Andrade AF, de Paula Queiroz RG, Scrideli CA, Tone LG, Valera ET.

Cancer Cell Int · research-article; journal article · DOI 10.1186/s12935-016-0306-5

Bibliografisk träff 2016-01-11

Histone deacetylase inhibitor abexinostat (S78454/PCI-24781) as a successful approach in a case of refractory peripheral angio-immunoblastic T-cell lymphoma, as a bridge to reduced intensity conditioning haplo-identical allogenic stem cell transplant.

Saillard C, El Cheikh J, Granata A, Coso D, Schiano JM, Bouabdallah R, Blaise D, Charrier N, Broussais F.

Leuk Lymphoma · letter; case reports · DOI 10.3109/10428194.2015.1061190

Bibliografisk träff 2015-01-01

HDAC Inhibitors as Novel Anti-Cancer Therapeutics.

De Souza C, Chatterji BP.

Recent Pat Anticancer Drug Discov · review; journal article · DOI 10.2174/1574892810666150317144511

Bibliografisk träff 2014-10-21

PCI-24781 down-regulates EZH2 expression and then promotes glioma apoptosis by suppressing the PIK3K/Akt/mTOR pathway.

Zhang W, Lv S, Liu J, Zang Z, Yin J, An N, Yang H, Song Y.

Genet Mol Biol · research-article; journal article · DOI 10.1590/s1415-47572014005000011

Bibliografisk träff 2014-08-01

RAD51 potentiates synergistic effects of chemotherapy with PCI-24781 and cis-diamminedichloroplatinum on gastric cancer.

He WL, Li YH, Hou WJ, Ke ZF, Chen XL, Lu LY, Cai SR, Song W, Zhang CH, He YL.

World J Gastroenterol · research support, non-u.s. gov't; research-article; journal article · DOI 10.3748/wjg.v20.i29.10094

Bibliografisk träff 2013-12-01

PCI-24781 (abexinostat), a novel histone deacetylase inhibitor, induces reactive oxygen species-dependent apoptosis and is synergistic with bortezomib in neuroblastoma.

Sholler GS, Currier EA, Dutta A, Slavik MA, Illenye SA, Mendonca MC, Dragon J, Roberts SS, Bond JP.

J Cancer Ther Res · research-article; journal article · DOI 10.7243/2049-7962-2-21

Bibliografisk träff 2013-11-27

Paradoxical regulation of hypoxia inducible factor-1α (HIF-1α) by histone deacetylase inhibitor in diffuse large B-cell lymphoma.

Bhalla S, Evens AM, Prachand S, Schumacker PT, Gordon LI.

PLoS One · research support, non-u.s. gov't; research-article; journal article · DOI 10.1371/journal.pone.0081333

Bibliografisk träff 2013-08-16

RuvBL2 is involved in histone deacetylase inhibitor PCI-24781-induced cell death in SK-N-DZ neuroblastoma cells.

Zhan Q, Tsai S, Lu Y, Wang C, Kwan Y, Ngai S.

PLoS One · research support, non-u.s. gov't; research-article; journal article · DOI 10.1371/journal.pone.0071663

Bibliografisk träff 2013-06-18

Pharmacokinetic/pharmacodynamic modelling-based optimisation of administration schedule for the histone deacetylase inhibitor abexinostat (S78454/PCI-24781) in phase I.

Fouliard S, Robert R, Jacquet-Bescond A, du Rieu QC, Balasubramanian S, Loury D, Loriot Y, Hollebecque A, Kloos I, Soria JC, Chenel M, Depil S.

Eur J Cancer · clinical trial, phase i; journal article · DOI 10.1016/j.ejca.2013.05.009

Bibliografisk träff 2013-06-05

Application of hematological toxicity modeling in clinical development of abexinostat (S-78454, PCI-24781), a new histone deacetylase inhibitor.

Chalret du Rieu Q, Fouliard S, Jacquet-Bescond A, Robert R, Kloos I, Depil S, Chatelut E, Chenel M.

Pharm Res · journal article · DOI 10.1007/s11095-013-1089-1

Bibliografisk träff 2013-05-28

MSH3 mismatch repair protein regulates sensitivity to cytotoxic drugs and a histone deacetylase inhibitor in human colon carcinoma cells.

Park JM, Huang S, Tougeron D, Sinicrope FA.

PLoS One · research-article; journal article; research support, n.i.h., extramural · DOI 10.1371/journal.pone.0065369

Bibliografisk träff 2012-02-09

The therapeutic effect of histone deacetylase inhibitor PCI-24781 on gallbladder carcinoma in BK5.erbB2 mice.

Kitamura T, Connolly K, Ruffino L, Ajiki T, Lueckgen A, DiGiovanni J, Kiguchi K.

J Hepatol · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.jhep.2012.01.018

Bibliografisk träff 2011-04-01

Histone deacetylase inhibitor PCI-24781 enhances chemotherapy-induced apoptosis in multidrug-resistant sarcoma cell lines.

Yang C, Choy E, Hornicek FJ, Wood KB, Schwab JH, Liu X, Mankin H, Duan Z.

Anticancer Res · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural

Bibliografisk träff 2010-05-12

Histone deacetylase inhibitor (HDACI) PCI-24781 potentiates cytotoxic effects of doxorubicin in bone sarcoma cells.

Yang C, Choy E, Hornicek FJ, Wood KB, Schwab JH, Liu X, Mankin H, Duan Z.

Cancer Chemother Pharmacol · research support, non-u.s. gov't; journal article; research support, n.i.h., extramural · DOI 10.1007/s00280-010-1344-7

Bibliografisk träff 2010-01-18

PCI-24781, a Novel Hydroxamic Acid HDAC Inhibitor, Exerts Cytotoxicity and Histone Alterations via Caspase-8 and FADD in Leukemia Cells.

Rivera-Del Valle N, Gao S, Miller CP, Fulbright J, Gonzales C, Sirisawad M, Steggerda S, Wheler J, Balasubramanian S, Chandra J.

Int J Cell Biol · research-article; journal article · DOI 10.1155/2010/207420

Bibliografisk träff 2009-05-05

Combining PCI-24781, a novel histone deacetylase inhibitor, with chemotherapy for the treatment of soft tissue sarcoma.

Lopez G, Liu J, Ren W, Wei W, Wang S, Lahat G, Zhu QS, Bornmann WG, McConkey DJ, Pollock RE, Lev DC.

Clin Cancer Res · journal article · DOI 10.1158/1078-0432.ccr-08-2714

Bibliografisk träff 2009-05-05

PCI-24781 induces caspase and reactive oxygen species-dependent apoptosis through NF-kappaB mechanisms and is synergistic with bortezomib in lymphoma cells.

Bhalla S, Balasubramanian S, David K, Sirisawad M, Buggy J, Mauro L, Prachand S, Miller R, Gordon LI, Evens AM.

Clin Cancer Res · research-article; journal article; research support, n.i.h., extramural · DOI 10.1158/1078-0432.ccr-08-2365

Bibliografisk träff 2007-11-27

HDAC inhibitor PCI-24781 decreases RAD51 expression and inhibits homologous recombination.

Adimoolam S, Sirisawad M, Chen J, Thiemann P, Ford JM, Buggy JJ.

Proc Natl Acad Sci U S A · research-article; journal article · DOI 10.1073/pnas.0707828104

Bibliografisk träff 2007-11-01

Radiosensitization by the histone deacetylase inhibitor PCI-24781.

Banuelos CA, Banáth JP, MacPhail SH, Zhao J, Reitsema T, Olive PL.

Clin Cancer Res · research support, non-u.s. gov't; journal article · DOI 10.1158/1078-0432.ccr-07-1126

Bibliografisk träff 2006-05-01

CRA-024781: a novel synthetic inhibitor of histone deacetylase enzymes with antitumor activity in vitro and in vivo.

Buggy JJ, Cao ZA, Bass KE, Verner E, Balasubramanian S, Liu L, Schultz BE, Young PR, Dalrymple SA.

Mol Cancer Ther · journal article · DOI 10.1158/1535-7163.mct-05-0442