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Publikationer i urvalet

11 träffar

Bibliografisk träff 2024-01-13

Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel.

Zhang SM, Paulin CBJ, Shu H, Yagüe-Capilla M, Michel M, Marttila P, Ortis F, Bwanika HC, Dirks C, Venkatram RP, Wiita E, Jemth AS, Almlöf I, Loseva O, Hormann FM, Koolmeister T, Linde E, Lee S, Llona-Minguez S, Haraldsson M, Axelsson H, Strömberg K, Homan EJ, Scobie M, Lundbäck T, Helleday T, Rudd SG.

iScience · research-article; journal article · DOI 10.1016/j.isci.2024.108907

Bibliografisk träff 2020-02-26

P450s under Restriction (PURE) Screen Using HepaRG and Primary Human Hepatocytes for Discovery of Novel HBV Antivirals.

Hartman GD, Kuduk SD, Espiritu C, Lam AM.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/acsmedchemlett.9b00630

Bibliografisk träff 2012-09-07

Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.

Warner DJ, Chen H, Cantin LD, Kenna JG, Stahl S, Walker CL, Noeske T.

Drug Metab Dispos · journal article · DOI 10.1124/dmd.112.047068

Bibliografisk träff 2010-09-20

Aldehyde oxidase: an enzyme of emerging importance in drug discovery.

Pryde DC, Dalvie D, Hu Q, Jones P, Obach RS, Tran TD.

J Med Chem · journal article · DOI 10.1021/jm100888d

Bibliografisk träff 2008-03-19

New selective inhibitors of steroid 11beta-hydroxylation in the adrenal cortex. Synthesis and structure-activity relationship of potent etomidate analogues.

Zolle IM, Berger ML, Hammerschmidt F, Hahner S, Schirbel A, Peric-Simov B.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm800012w

Bibliografisk träff 2007-06-09

Biotransformation of polymethoxylated flavonoids: access to their 4'-O-demethylated metabolites.

Buisson D, Quintin J, Lewin G.

J Nat Prod · journal article · DOI 10.1021/np070084q

Bibliografisk träff 2006-08-01

Synthesis of trifluoromethylaryl diazirine and benzophenone derivatives of etomidate that are potent general anesthetics and effective photolabels for probing sites on ligand-gated ion channels.

Husain SS, Nirthanan S, Ruesch D, Solt K, Cheng Q, Li GD, Arevalo E, Olsen RW, Raines DE, Forman SA, Cohen JB, Miller KW.

J Med Chem · journal article; research support, n.i.h., extramural · DOI 10.1021/jm051207b

Bibliografisk träff 2004-05-01

Thioxanthene-derived analogs as sigma(1) receptor ligands.

Glennon RA, Ismaiel AM, Ablordeppey S, El-Ashmawy M, Fisher JB.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2004.02.018

Bibliografisk träff 1994-11-01

Conformational analysis, pharmacophore identification, and comparative molecular field analysis of ligands for the neuromodulatory sigma 3 receptor.

Myers AM, Charifson PS, Owens CE, Kula NS, McPhail AT, Baldessarini RJ, Booth RG, Wyrick SD.

J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00050a008

Bibliografisk träff 1992-04-01

Synthesis of 2-(p-chlorobenzyl)-3-aryl-6-methoxybenzofurans as selective ligands for antiestrogen-binding sites. Effects on cell proliferation and cholesterol synthesis.

Teo CC, Kon OL, Sim KY, Ng SC.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00086a002

Bibliografisk träff 1985-03-01

[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.

McNeal ET, Lewandowski GA, Daly JW, Creveling CR.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00381a019