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Publikationer i urvalet

18 träffar

Bibliografisk träff 2024-01-13

Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel.

Zhang SM, Paulin CBJ, Shu H, Yagüe-Capilla M, Michel M, Marttila P, Ortis F, Bwanika HC, Dirks C, Venkatram RP, Wiita E, Jemth AS, Almlöf I, Loseva O, Hormann FM, Koolmeister T, Linde E, Lee S, Llona-Minguez S, Haraldsson M, Axelsson H, Strömberg K, Homan EJ, Scobie M, Lundbäck T, Helleday T, Rudd SG.

iScience · research-article; journal article · DOI 10.1016/j.isci.2024.108907

Bibliografisk träff 2021-10-12

Structure Activity Relationships for a Series of Eticlopride-Based Dopamine D2/D3 Receptor Bitopic Ligands.

Shaik AB, Boateng CA, Battiti FO, Bonifazi A, Cao J, Chen L, Chitsazi R, Ravi S, Lee KH, Shi L, Newman AH.

J Med Chem · research support, n.i.h., intramural; research-article; journal article · DOI 10.1021/acs.jmedchem.1c01353

Bibliografisk träff 2017-10-01

D4 dopamine receptor high-resolution structures enable the discovery of selective agonists.

Wang S, Wacker D, Levit A, Che T, Betz RM, McCorvy JD, Venkatakrishnan AJ, Huang XP, Dror RO, Shoichet BK, Roth BL.

Science · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1126/science.aan5468

Bibliografisk träff 2016-11-28

Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors.

Cao J, Slack RD, Bakare OM, Burzynski C, Rais R, Slusher BS, Kopajtic T, Bonifazi A, Ellenberger MP, Yano H, He Y, Bi GH, Xi ZX, Loland CJ, Newman AH.

J Med Chem · research-article; journal article · DOI 10.1021/acs.jmedchem.6b01373

Bibliografisk träff 2014-06-03

Tranylcypromine substituted cis-hydroxycyclobutylnaphthamides as potent and selective dopamine D₃ receptor antagonists.

Chen J, Levant B, Jiang C, Keck TM, Newman AH, Wang S.

J Med Chem · research support, n.i.h., intramural; rapid-communication; journal article; research support, n.i.h., extramural · DOI 10.1021/jm401798r

Bibliografisk träff 2012-06-07

Molecular determinants of selectivity and efficacy at the dopamine D3 receptor.

Newman AH, Beuming T, Banala AK, Donthamsetti P, Pongetti K, LaBounty A, Levy B, Cao J, Michino M, Luedtke RR, Javitch JA, Shi L.

J Med Chem · research support, n.i.h., intramural; research-article; journal article · DOI 10.1021/jm300482h

Bibliografisk träff 2008-02-29

Synthesis, radiofluorination, and in vitro evaluation of pyrazolo[1,5-a]pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET.

Prante O, Tietze R, Hocke C, Löber S, Hübner H, Kuwert T, Gmeiner P.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm701375u

Bibliografisk träff 2003-10-01

Molecular modeling of the three-dimensional structure of dopamine 3 (D3) subtype receptor: discovery of novel and potent D3 ligands through a hybrid pharmacophore- and structure-based database searching approach.

Varady J, Wu X, Fang X, Min J, Hu Z, Levant B, Wang S.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm030085p

Bibliografisk träff 2003-05-01

2002 Medicinal Chemistry Division Award address: monoamine transporters and opioid receptors. Targets for addiction therapy.

Carroll FI.

J Med Chem · research support, u.s. gov't, p.h.s.; address; review · DOI 10.1021/jm030092d

Bibliografisk träff 1993-10-01

Conformationally restricted analogues of remoxipride as potential antipsychotic agents.

Norman MH, Kelley JL, Hollingsworth EB.

J Med Chem · journal article · DOI 10.1021/jm00074a023

Bibliografisk träff 1993-01-01

Fluorinated and iodinated dopamine agents: D2 imaging agents for PET and SPECT.

Chumpradit S, Kung MP, Billings J, Mach R, Kung HF.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00054a005

Bibliografisk träff 1993-01-01

Effects of solvation on the ionization and conformation of raclopride and other antidopaminergic 6-methoxysalicylamides: insight into the pharmacophore.

Tsai RS, Carrupt PA, Testa B, Gaillard P, el Tayar N, Högberg T.

J Med Chem · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00054a002

Bibliografisk träff 1991-05-01

Synthesis and in vitro evaluation of 2,3-dimethoxy-5-(fluoroalkyl)-substituted benzamides: high-affinity ligands for CNS dopamine D2 receptors.

Bishop JE, Mathis CA, Gerdes JM, Whitney JM, Eaton AM, Mailman RB.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/jm00109a013

Bibliografisk träff 1991-03-01

Potential antipsychotic agents. 9. Synthesis and stereoselective dopamine D-2 receptor blockade of a potent class of substituted (R)-N-[(1-benzyl-2-pyrrolidinyl)methyl]benzamides. Relations to other side chain congeners.

Högberg T, Ström P, de Paulis T, Stensland B, Csöregh I, Lundin K, Hall H, Ogren SO.

J Med Chem · comparative study; journal article · DOI 10.1021/jm00107a012

Bibliografisk träff 1990-04-01

Potential antipsychotic agents 5. Synthesis and antidopaminergic properties of substituted 5,6-dimethoxysalicylamides and related compounds.

Högberg T, Bengtsson S, de Paulis T, Johansson L, Ström P, Hall H, Ogren SO.

J Med Chem · journal article · DOI 10.1021/jm00166a012

Bibliografisk träff 1990-01-01

Synthesis and characterization of iodobenzamide analogues: potential D-2 dopamine receptor imaging agents.

Murphy RA, Kung HF, Kung MP, Billings J.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00163a029

Bibliografisk träff 1988-05-01

Dopamine D-2 receptor imaging radiopharmaceuticals: synthesis, radiolabeling, and in vitro binding of (R)-(+)- and (S)-(-)-3-iodo-2-hydroxy-6-methoxy-N- [(1-ethyl-2-pyrrolidinyl)methyl]benzamide.

Kung HF, Kasliwal R, Pan SG, Kung MP, Mach RH, Guo YZ.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00400a027

Bibliografisk träff 1986-01-01

Potential neuroleptic agents. 4. Chemistry, behavioral pharmacology, and inhibition of [3H]spiperone binding of 3,5-disubstituted N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-methoxysalicylamides.

de Paulis T, Kumar Y, Johansson L, Rämsby S, Hall H, Sällemark M, Angeby-Möller K, Ogren SO.

J Med Chem · comparative study; journal article · DOI 10.1021/jm00151a010

Gå till forskningen.

Publikationer i urvalet

Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel.

Structure Activity Relationships for a Series of Eticlopride-Based Dopamine D<sub>2</sub>/D<sub>3</sub> Receptor Bitopic Ligands.

D<sub>4</sub> dopamine receptor high-resolution structures enable the discovery of selective agonists.

Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors.

Tranylcypromine substituted cis-hydroxycyclobutylnaphthamides as potent and selective dopamine D₃ receptor antagonists.

Molecular determinants of selectivity and efficacy at the dopamine D3 receptor.

Synthesis, radiofluorination, and in vitro evaluation of pyrazolo[1,5-a]pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET.

Molecular modeling of the three-dimensional structure of dopamine 3 (D3) subtype receptor: discovery of novel and potent D3 ligands through a hybrid pharmacophore- and structure-based database searching approach.

2002 Medicinal Chemistry Division Award address: monoamine transporters and opioid receptors. Targets for addiction therapy.

Conformationally restricted analogues of remoxipride as potential antipsychotic agents.

Fluorinated and iodinated dopamine agents: D2 imaging agents for PET and SPECT.

Effects of solvation on the ionization and conformation of raclopride and other antidopaminergic 6-methoxysalicylamides: insight into the pharmacophore.

Synthesis and in vitro evaluation of 2,3-dimethoxy-5-(fluoroalkyl)-substituted benzamides: high-affinity ligands for CNS dopamine D2 receptors.

Potential antipsychotic agents. 9. Synthesis and stereoselective dopamine D-2 receptor blockade of a potent class of substituted (R)-N-[(1-benzyl-2-pyrrolidinyl)methyl]benzamides. Relations to other side chain congeners.

Potential antipsychotic agents 5. Synthesis and antidopaminergic properties of substituted 5,6-dimethoxysalicylamides and related compounds.

Synthesis and characterization of iodobenzamide analogues: potential D-2 dopamine receptor imaging agents.

Dopamine D-2 receptor imaging radiopharmaceuticals: synthesis, radiolabeling, and in vitro binding of (R)-(+)- and (S)-(-)-3-iodo-2-hydroxy-6-methoxy-N- [(1-ethyl-2-pyrrolidinyl)methyl]benzamide.

Potential neuroleptic agents. 4. Chemistry, behavioral pharmacology, and inhibition of [3H]spiperone binding of 3,5-disubstituted N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-methoxysalicylamides.