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Publikationer i urvalet

29 träffar

Bibliografisk träff 2024-01-13

Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel.

Zhang SM, Paulin CBJ, Shu H, Yagüe-Capilla M, Michel M, Marttila P, Ortis F, Bwanika HC, Dirks C, Venkatram RP, Wiita E, Jemth AS, Almlöf I, Loseva O, Hormann FM, Koolmeister T, Linde E, Lee S, Llona-Minguez S, Haraldsson M, Axelsson H, Strömberg K, Homan EJ, Scobie M, Lundbäck T, Helleday T, Rudd SG.

iScience · research-article; journal article · DOI 10.1016/j.isci.2024.108907

Bibliografisk träff 2020-01-23

Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery.

Solbak SMØ, Zang J, Narayanan D, Høj LJ, Bucciarelli S, Softley C, Meier S, Langkilde AE, Gotfredsen CH, Sattler M, Bach A.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.9b01492

Bibliografisk träff 2017-05-02

4-Phenyl quinoline derivatives as potential serotonin receptor ligands with antiproliferative activity.

Joshi PV, Sayed AA, RaviKumar A, Puranik VG, Zinjarde SS.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2017.05.002

Bibliografisk träff 2013-04-09

Biophysical fragment screening of the β1-adrenergic receptor: identification of high affinity arylpiperazine leads using structure-based drug design.

Christopher JA, Brown J, Doré AS, Errey JC, Koglin M, Marshall FH, Myszka DG, Rich RL, Tate CG, Tehan B, Warne T, Congreve M.

J Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/jm400140q

Bibliografisk träff 2012-01-15

Synthesis, in vitro binding studies and docking of long-chain arylpiperazine nitroquipazine analogues, as potential serotonin transporter inhibitors.

Jarończyk M, Wołosewicz K, Gabrielsen M, Nowak G, Kufareva I, Mazurek AP, Ravna AW, Abagyan R, Bojarski AJ, Sylte I, Chilmonczyk Z.

Eur J Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.ejmech.2012.01.012

Bibliografisk träff 2009-11-01

Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characterization.

Butini S, Budriesi R, Hamon M, Morelli E, Gemma S, Brindisi M, Borrelli G, Novellino E, Fiorini I, Ioan P, Chiarini A, Cagnotto A, Mennini T, Fracasso C, Caccia S, Campiani G.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm901126m

Bibliografisk träff 2009-10-01

Physical binding pocket induction for affinity prediction.

Langham JJ, Cleves AE, Spitzer R, Kirshner D, Jain AN.

J Med Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/jm901096y

Bibliografisk träff 2009-06-01

Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships.

Morelli E, Gemma S, Budriesi R, Campiani G, Novellino E, Fattorusso C, Catalanotti B, Coccone SS, Ros S, Borrelli G, Persico M, Fiorini I, Nacci V, Ioan P, Chiarini A, Hamon M, Cagnotto A, Mennini T, Fracasso C, Colovic M, Caccia S, Butini S.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm900018b

Bibliografisk träff 2007-08-28

Pharmacological characteristics and binding modes of caracurine V analogues and related compounds at the neuronal alpha7 nicotinic acetylcholine receptor.

Jensen AA, Zlotos DP, Liljefors T.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm070574f

Bibliografisk träff 2003-07-01

Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).

Glennon RA.

J Med Chem · research support, u.s. gov't, p.h.s.; review; journal article · DOI 10.1021/jm030030n

Bibliografisk träff 2002-10-01

Electrostatic potential surfaces of 5-HT(3)R agonists suggest accessory cation-pi site adjacent to agonist binding domain.

Parihar HS, Kirschbaum KS.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/s0960-894x(02)00514-0

Bibliografisk träff 2000-07-01

Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 1.

Lee BS, Chu S, Lee BC, Chi DY, Choe YS, Jeong KJ, Jin C.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/s0960-894x(00)00290-0

Bibliografisk träff 1999-10-01

Pyrroloquinoxaline derivatives as high-affinity and selective 5-HT(3) receptor agonists: synthesis, further structure-activity relationships, and biological studies.

Campiani G, Morelli E, Gemma S, Nacci V, Butini S, Hamon M, Novellino E, Greco G, Cagnotto A, Goegan M, Cervo L, Dalla Valle F, Fracasso C, Caccia S, Mennini T.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm990151g

Bibliografisk träff 1999-05-01

Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 2. Molecular basis of the intrinsic efficacy of arylpiperazine derivatives at the central 5-HT3 receptors.

Cappelli A, Anzini M, Vomero S, Canullo L, Mennuni L, Makovec F, Doucet E, Hamon M, Menziani MC, De Benedetti PG, Bruni G, Romeo MR, Giorgi G, Donati A.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm981112s

Bibliografisk träff 1998-05-01

(R)-(+)-2-[[[3-(Morpholinomethyl)-2H-chromen-8-yl]oxy]methyl] morpholine methanesulfonate: a new selective rat 5-hydroxytryptamine1B receptor antagonist.

Berg S, Larsson LG, Rényi L, Ross SB, Thorberg SO, Thorell-Svantesson G.

J Med Chem · journal article · DOI 10.1021/jm970806i

Bibliografisk träff 1998-02-01

Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 1. Mapping the central 5-HT3 receptor binding site by arylpiperazine derivatives.

Cappelli A, Anzini M, Vomero S, Mennuni L, Makovec F, Doucet E, Hamon M, Bruni G, Romeo MR, Menziani MC, De Benedetti PG, Langer T.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm970645i

Bibliografisk träff 1998-01-01

5-HT3 antagonists derived from aminopyridazine-type muscarinic M1 agonists.

Rival Y, Hoffmann R, Didier B, Rybaltchenko V, Bourguignon JJ, Wermuth CG.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm9705418

Bibliografisk träff 1997-10-01

Novel and highly potent 5-HT3 receptor agonists based on a pyrroloquinoxaline structure.

Campiani G, Cappelli A, Nacci V, Anzini M, Vomero S, Hamon M, Cagnotto A, Fracasso C, Uboldi C, Caccia S, Consolo S, Mennini T.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm970376w

Bibliografisk träff 1997-06-01

Novel and selective partial agonists of 5-HT3 receptors. 2. Synthesis and biological evaluation of piperazinopyridopyrrolopyrazines, piperazinopyrroloquinoxalines, and piperazinopyridopyrroloquinoxalines.

Prunier H, Rault S, Lancelot JC, Robba M, Renard P, Delagrange P, Pfeiffer B, Caignard DH, Misslin R, Guardiola-Lemaitre B, Hamon M.

J Med Chem · journal article · DOI 10.1021/jm960501o

Bibliografisk träff 1996-09-01

Structure-activity relationships for the binding of arylpiperazines and arylbiguanides at 5-HT3 serotonin receptors.

Dukat M, Abdel-Rahman AA, Ismaiel AM, Ingher S, Teitler M, Gyermek L, Glennon RA.

J Med Chem · journal article · DOI 10.1021/jm9603936

Bibliografisk träff 1996-05-01

Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines.

Rault S, Lancelot JC, Prunier H, Robba M, Renard P, Delagrange P, Pfeiffer B, Caignard DH, Guardiola-Lemaitre B, Hamon M.

J Med Chem · journal article · DOI 10.1021/jm950543x

Bibliografisk träff 1995-07-01

Novel, potent, and selective 5-HT3 receptor antagonists based on the arylpiperazine skeleton: synthesis, structure, biological activity, and comparative molecular field analysis studies.

Anzini M, Cappelli A, Vomero S, Giorgi G, Langer T, Hamon M, Merahi N, Emerit BM, Cagnotto A, Skorupska M.

J Med Chem · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00014a021

Bibliografisk träff 1990-12-01

Synthesis and biochemical evaluation of tritium-labeled 1-methyl-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-1H-indazole-3-carboxa mide, a useful radioligand for 5HT3 receptors.

Robertson DW, Bloomquist W, Cohen ML, Reid LR, Schenck K, Wong DT.

J Med Chem · journal article · DOI 10.1021/jm00174a013

Bibliografisk träff 1990-11-01

Synthesis, in vitro binding profile, and central nervous system penetrability of the highly potent 5-HT3 receptor antagonist [3H]-4-(2-methoxyphenyl)-2-[4(5)-methyl-5(4)-imidazolylmethyl]thiazole.

Rosen T, Seeger TF, McLean S, Nagel AA, Ives JL, Guarino KJ, Bryce D, Furman J, Roth RW, Chalabi PM.

J Med Chem · journal article · DOI 10.1021/jm00173a017

Bibliografisk träff 1990-06-01

Conformation-activity relationship study of 5-HT3 receptor antagonists and a definition of a model for this receptor site.

Hibert MF, Hoffmann R, Miller RC, Carr AA.

J Med Chem · journal article · DOI 10.1021/jm00168a011

Bibliografisk träff 1987-01-01

Central serotonin receptors as targets for drug research.

Glennon RA.

J Med Chem · review; journal article · DOI 10.1021/jm00384a001

Bibliografisk träff 1986-11-01

5-HT1 and 5-HT2 binding characteristics of some quipazine analogues.

Glennon RA, Slusher RM, Lyon RA, Titeler M, McKenney JD.

J Med Chem · journal article · DOI 10.1021/jm00161a038

Bibliografisk träff 1985-10-01

Design, synthesis, and pharmacological activities of 2-substituted 4-phenylquinolines as potential antidepressant drugs.

Alhaider AA, Abdelkader MA, Lien EJ.

J Med Chem · journal article · DOI 10.1021/jm00148a004

Bibliografisk träff 1978-06-01

Piperazinylpyrazines with central serotoninmimetic activity.

Lumma WC, Hartman RD, Saari WS, Engelhardt EL, Hirschmann R, Clineschmidt BV, Torchiana ML, Stone CA.

J Med Chem · journal article · DOI 10.1021/jm00204a007