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Publikationer i urvalet

20 träffar

Bibliografisk träff 2024-01-13

Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel.

Zhang SM, Paulin CBJ, Shu H, Yagüe-Capilla M, Michel M, Marttila P, Ortis F, Bwanika HC, Dirks C, Venkatram RP, Wiita E, Jemth AS, Almlöf I, Loseva O, Hormann FM, Koolmeister T, Linde E, Lee S, Llona-Minguez S, Haraldsson M, Axelsson H, Strömberg K, Homan EJ, Scobie M, Lundbäck T, Helleday T, Rudd SG.

iScience · research-article; journal article · DOI 10.1016/j.isci.2024.108907

Bibliografisk träff 2021-09-01

Activity of <i>Mitragyna speciosa</i> ("Kratom") Alkaloids at Serotonin Receptors.

León F, Obeng S, Mottinelli M, Chen Y, King TI, Berthold EC, Kamble SH, Restrepo LF, Patel A, Gamez-Jimenez LR, Lopera-Londoño C, Hiranita T, Sharma A, Hampson AJ, Canal CE, McMahon LR, McCurdy CR.

J Med Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.1c00726

Bibliografisk träff 2021-04-09

Radioligand and computational insight in structure - Activity relationship of saccharin derivatives being ipsapirone and revospirone analogues.

Kułaga D, Jaśkowska J, Satała G.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2021.128028

Bibliografisk träff 2019-09-03

Design, synthesis and biological evaluation of novel serotonin and dopamine receptor ligands being 6-bromohexyl saccharine derivatives.

Kułaga D, Jaśkowska J, Satała G.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2019.126667

Bibliografisk träff 2012-09-07

Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.

Warner DJ, Chen H, Cantin LD, Kenna JG, Stahl S, Walker CL, Noeske T.

Drug Metab Dispos · journal article · DOI 10.1124/dmd.112.047068

Bibliografisk träff 2009-10-01

Physical binding pocket induction for affinity prediction.

Langham JJ, Cleves AE, Spitzer R, Kirshner D, Jain AN.

J Med Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/jm901096y

Bibliografisk träff 2008-07-04

Synthesis of new arylpiperazinylalkylthiobenzimidazole, benzothiazole, or benzoxazole derivatives as potent and selective 5-HT1A serotonin receptor ligands.

Siracusa MA, Salerno L, Modica MN, Pittalà V, Romeo G, Amato ME, Nowak M, Bojarski AJ, Mereghetti I, Cagnotto A, Mennini T.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm800176x

Bibliografisk träff 2007-11-01

An antidepressant that extends lifespan in adult Caenorhabditis elegans.

Petrascheck M, Ye X, Buck LB.

Nature · research support, non-u.s. gov't; journal article; research support, n.i.h., extramural · DOI 10.1038/nature05991

Bibliografisk träff 2006-06-01

An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.

Becker OM, Dhanoa DS, Marantz Y, Chen D, Shacham S, Cheruku S, Heifetz A, Mohanty P, Fichman M, Sharadendu A, Nudelman R, Kauffman M, Noiman S.

J Med Chem · journal article · DOI 10.1021/jm0508641

Bibliografisk träff 2004-09-01

Indolebutylamines as selective 5-HT(1A) agonists.

Heinrich T, Böttcher H, Bartoszyk GD, Greiner HE, Seyfried CA, Van Amsterdam C.

J Med Chem · journal article · DOI 10.1021/jm040792y

Bibliografisk träff 1998-09-01

Functional characteristics of a series of N4-substituted 1-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazines as 5-HT1A receptor ligands. Structure-activity relationships.

van Steen BJ, van Wijngaarden I, Ronken E, Soudijn W.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(98)00406-5

Bibliografisk träff 1998-09-01

Selective alpha-1a adrenergic receptor antagonists. Effects of pharmacophore regio- and stereochemistry on potency and selectivity.

Patane MA, DiPardo RM, Price RP, Chang RS, Ransom RW, O'Malley SS, Di Salvo J, Bock MG.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(98)00451-x

Bibliografisk träff 1996-10-01

3-amino-3,4-dihydro-2H-1-benzopyran derivatives as 5-HT1A receptor ligands and potential anxiolytic agents. 2. Synthesis and quantitative structure-activity relationship studies of spiro[pyrrolidine- and piperidine-2,3'(2'H)-benzopyrans].

Comoy C, Marot C, Podona T, Baudin ML, Morin-Allory L, Guillaumet G, Pfeiffer B, Caignard DH, Renard P, Rettori MC, Adam G, Guardiola-Lemaitre B.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm950861w

Bibliografisk träff 1995-05-01

Buspirone analogues as ligands of the 5-HT1A receptor. 1. The molecular structure of buspirone and its two analogues.

Chilmonczyk Z, Leś A, Woźniakowska A, Cybulski J, Kozioł AE, Gdaniec M.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00010a015

Bibliografisk träff 1994-06-01

3,4-Dihydro-3-amino-2H-1-benzopyran derivatives as 5-HT1A receptor ligands and potential anxiolytic agents. 1. Synthesis and structure--activity relationship studies.

Podona T, Guardiola-Lemaître B, Caignard DH, Adam G, Pfeiffer B, Renard P, Guillaumet G.

J Med Chem · journal article · DOI 10.1021/jm00038a007

Bibliografisk träff 1993-09-01

Structure-affinity relationship studies on 5-HT1A receptor ligands. 1. Heterobicyclic phenylpiperazines with N4-alkyl substituents.

van Steen BJ, van Wijngaarden I, Tulp MT, Soudijn W.

J Med Chem · journal article · DOI 10.1021/jm00071a006

Bibliografisk träff 1992-06-01

Structure-activity relationship studies of central nervous system agents. 5. Effect of the hydrocarbon chain on the affinity of 4-substituted 1-(3-chlorophenyl)piperazines for 5-HT1A receptor site.

Mokrosz JL, Pietrasiewicz M, Duszyńska B, Cegła MT.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00091a004

Bibliografisk träff 1989-05-01

Synthesis and structure-activity relationship of substituted tetrahydro- and hexahydro-1,2-benzisothiazol-3-one 1,1-dioxides and thiadiazinones: potential anxiolytic agents.

Abou-Gharbia M, Moyer JA, Patel U, Webb M, Schiehser G, Andree T, Haskins JT.

J Med Chem · journal article · DOI 10.1021/jm00125a016

Bibliografisk träff 1988-07-01

Polycyclic aryl- and heteroarylpiperazinyl imides as 5-HT1A receptor ligands and potential anxiolytic agents: synthesis and structure-activity relationship studies.

Abou-Gharbia M, Patel UR, Webb MB, Moyer JA, Andree TH, Muth EA.

J Med Chem · comparative study; journal article · DOI 10.1021/jm00402a023

Bibliografisk träff 1987-01-01

Central serotonin receptors as targets for drug research.

Glennon RA.

J Med Chem · review; journal article · DOI 10.1021/jm00384a001