ICRF-193, an anticancer topoisomerase II inhibitor, induces arched telophase spindles that snap, leading to a ploidy increase in fission yeast.
Nakazawa N, Mehrotra R, Arakawa O, Yanagida M.
Genes Cells · journal article · DOI 10.1111/gtc.12397 PUBLIKATIONSREGISTRET
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Publikationer i urvalet
8 träffarThe topoisomerase II catalytic inhibitor ICRF-193 preferentially targets telomeres that are capped by TRF2.
Chen L, Zhu X, Zou Y, Xing J, Gilson E, Lu Y, Ye J.
Am J Physiol Cell Physiol · research support, non-u.s. gov't; journal article · DOI 10.1152/ajpcell.00321.2014DNA topoisomerase IIα controls replication origin cluster licensing and firing time in Xenopus egg extracts.
Gaggioli V, Le Viet B, Germe T, Hyrien O.
Nucleic Acids Res · research support, non-u.s. gov't; research-article; journal article · DOI 10.1093/nar/gkt494Cell cycle-dependent DNA damage signaling induced by ICRF-193 involves ATM, ATR, CHK2, and BRCA1.
Park I, Avraham HK.
Exp Cell Res · research support, non-u.s. gov't; journal article; research support, n.i.h., extramural · DOI 10.1016/j.yexcr.2006.02.029Topoisomerase II-DNA complexes trapped by ICRF-193 perturb chromatin structure.
Germe T, Hyrien O.
EMBO Rep · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/sj.embor.7400465Topoisomerase II poisoning by ICRF-193.
Huang KC, Gao H, Yamasaki EF, Grabowski DR, Liu S, Shen LL, Chan KK, Ganapathi R, Snapka RM.
J Biol Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1074/jbc.m104383200Probing the interaction of the cytotoxic bisdioxopiperazine ICRF-193 with the closed enzyme clamp of human topoisomerase IIalpha.
Patel S, Jazrawi E, Creighton AM, Austin CA, Fisher LM.
Mol Pharmacol · research support, non-u.s. gov't; journal article · DOI 10.1124/mol.58.3.560Decreased thymosin beta4 in apoptosis induced by a variety of antitumor drugs.
Iguchi K, Usami Y, Hirano K, Hamatake M, Shibata M, Ishida R.
Biochem Pharmacol · research support, non-u.s. gov't; journal article · DOI 10.1016/s0006-2952(99)00030-1