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Publikationer i urvalet

11 träffar

Bibliografisk träff 2020-07-28

Development of SKI-349, a dual-targeted inhibitor of sphingosine kinase and microtubule polymerization.

Hengst JA, Hegde S, Paulson RF, Yun JK.

Bioorg Med Chem Lett · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2020.127453

Bibliografisk träff 2020-04-06

Chemotherapy for human schistosomiasis: how far have we come? What's new? Where do we go from here?

Dziwornu GA, Attram HD, Gachuhi S, Chibale K.

RSC Med Chem · review-article; review; journal article · DOI 10.1039/d0md00062k

Bibliografisk träff 2019-06-26

Why Some Targets Benefit from beyond Rule of Five Drugs.

Egbert M, Whitty A, Keserű GM, Vajda S.

J Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.8b01732

Bibliografisk träff 2015-07-22

Structure-Guided Design of Novel l-Cysteine Derivatives as Potent KSP Inhibitors.

Ogo N, Ishikawa Y, Sawada J, Matsuno K, Hashimoto A, Asai A.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/acsmedchemlett.5b00221

Bibliografisk träff 2014-12-02

Discovery of potent KIFC1 inhibitors using a method of integrated high-throughput synthesis and screening.

Yang B, Lamb ML, Zhang T, Hennessy EJ, Grewal G, Sha L, Zambrowski M, Block MH, Dowling JE, Su N, Wu J, Deegan T, Mikule K, Wang W, Kaspera R, Chuaqui C, Chen H.

J Med Chem · journal article · DOI 10.1021/jm501179r

Bibliografisk träff 2013-10-02

Synthesis, biological evaluation and molecular docking studies of flavone and isoflavone derivatives as a novel class of KSP (kinesin spindle protein) inhibitors.

Dong JJ, Li QS, Liu ZP, Wang SF, Zhao MY, Yang YH, Wang XM, Zhu HL.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2013.09.042

Bibliografisk träff 2013-02-27

Optimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models.

Good JA, Wang F, Rath O, Kaan HY, Talapatra SK, Podgórski D, MacKay SP, Kozielski F.

J Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/jm3014597

Bibliografisk träff 2012-11-24

Fluorinated quinazolinones as potential radiotracers for imaging kinesin spindle protein expression.

Holland JP, Jones MW, Cohrs S, Schibli R, Fischer E.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2012.11.013

Bibliografisk träff 2012-02-13

Triphenylbutanamines: kinesin spindle protein inhibitors with in vivo antitumor activity.

Wang F, Good JA, Rath O, Kaan HY, Sutcliffe OB, Mackay SP, Kozielski F.

J Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/jm201195m

Bibliografisk träff 2007-10-07

ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism.

Luo L, Parrish CA, Nevins N, McNulty DE, Chaudhari AM, Carson JD, Sudakin V, Shaw AN, Lehr R, Zhao H, Sweitzer S, Lad L, Wood KW, Sakowicz R, Annan RS, Huang PS, Jackson JR, Dhanak D, Copeland RA, Auger KR.

Nat Chem Biol · journal article · DOI 10.1038/nchembio.2007.34

Bibliografisk träff 2007-04-29

Synthesis and SAR of thiophene containing kinesin spindle protein (KSP) inhibitors.

Pinkerton AB, Lee TT, Hoffman TZ, Wang Y, Kahraman M, Cook TG, Severance D, Gahman TC, Noble SA, Shiau AK, Davis RL.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2007.04.076