Modulators for palmitoylation of proteins and small molecules.
Fan Z, Hao Y, Huo Y, Cao F, Li L, Xu J, Song Y, Yang K.
Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2024.116408 PUBLIKATIONSREGISTRET
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Publikationer i urvalet
11 träffarIdentification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel.
Zhang SM, Paulin CBJ, Shu H, Yagüe-Capilla M, Michel M, Marttila P, Ortis F, Bwanika HC, Dirks C, Venkatram RP, Wiita E, Jemth AS, Almlöf I, Loseva O, Hormann FM, Koolmeister T, Linde E, Lee S, Llona-Minguez S, Haraldsson M, Axelsson H, Strömberg K, Homan EJ, Scobie M, Lundbäck T, Helleday T, Rudd SG.
iScience · research-article; journal article · DOI 10.1016/j.isci.2024.108907A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs.
Sutherland JJ, Yonchev D, Fekete A, Urban L.
Nat Commun · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/s41467-023-40064-9Mapping human microbiome drug metabolism by gut bacteria and their genes.
Zimmermann M, Zimmermann-Kogadeeva M, Wegmann R, Goodman AL.
Nature · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1038/s41586-019-1291-3Discovery and Optimization of 2-Amino-4-methylquinazoline Derivatives as Highly Potent Phosphatidylinositol 3-Kinase Inhibitors for Cancer Treatment.
Lin S, Wang C, Ji M, Wu D, Lv Y, Zhang K, Dong Y, Jin J, Chen J, Zhang J, Sheng L, Li Y, Chen X, Xu H.
J Med Chem · journal article · DOI 10.1021/acs.jmedchem.8b00416Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.
Ceccarelli SM, Chomienne O, Gubler M, Arduini A.
J Med Chem · journal article · DOI 10.1021/jm100809gCheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Fourches D, Barnes JC, Day NC, Bradley P, Reed JZ, Tropsha A.
Chem Res Toxicol · research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/tx900326kDiscovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents.
Cheng JF, Huang Y, Penuliar R, Nishimoto M, Liu L, Arrhenius T, Yang G, O'leary E, Barbosa M, Barr R, Dyck JR, Lopaschuk GD, Nadzan AM.
J Med Chem · journal article · DOI 10.1021/jm0605029Heteroaryl substituted bis-trifluoromethyl carbinols as malonyl-CoA decarboxylase inhibitors.
Cheng JF, Mak CC, Huang Y, Penuliar R, Nishimoto M, Zhang L, Chen M, Wallace D, Arrhenius T, Chu D, Yang G, Barbosa M, Barr R, Dyck JR, Lopaschuk GD, Nadzan AM.
Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2006.03.100Synthesis and structure-activity relationship of small-molecule malonyl coenzyme A decarboxylase inhibitors.
Cheng JF, Chen M, Wallace D, Tith S, Haramura M, Liu B, Mak CC, Arrhenius T, Reily S, Brown S, Thorn V, Harmon C, Barr R, Dyck JR, Lopaschuk GD, Nadzan AM.
J Med Chem · journal article · DOI 10.1021/jm050109n[Drug-induced liver injury; fourteenth updated edition of the bibliographic database of liver injuries and related drugs].
Biour M, Ben Salem C, Chazouillères O, Grangé JD, Serfaty L, Poupon R.
Gastroenterol Clin Biol · bibliography; journal article · DOI 10.1016/s0399-8320(04)95062-2