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Publikationer som ChEBI hänvisar till för (4,6-dimethyl-5-pyrimidinyl)-[4-[(3S)-4-[(1R)-2-methoxy-1-[4-(trifluoromethyl)phenyl]ethyl]-3-methyl-1-piperazinyl]-4-methyl-1-piperidinyl]methanone. Visa hela publikationsregistret

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Publikationer i urvalet

18 träffar

Bibliografisk träff 2020-12-07

Potent leads based on CA-19L, an anti-HIV active HIV-1 capsid fragment.

Tsuji K, Wang R, Kobayakawa T, Owusu KB, Fujino M, Kaneko M, Yamamoto N, Murakami T, Tamamura H.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2020.115923

Bibliografisk träff 2020-04-08

Exploratory studies on CA-15L, an anti-HIV active HIV-1 capsid fragment.

Tsuji K, Owusu KB, Kobayakawa T, Wang R, Fujino M, Kaneko M, Yamamoto N, Murakami T, Tamamura H.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2020.115488

Bibliografisk träff 2018-01-31

Recent updates for designing CCR5 antagonists as anti-retroviral agents.

Shah HR, Savjani JK.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2018.01.085

Bibliografisk träff 2017-03-10

Structural Analysis of Chemokine Receptor-Ligand Interactions.

Arimont M, Sun SL, Leurs R, Smit M, de Esch IJP, de Graaf C.

J Med Chem · research support, non-u.s. gov't; review-article; review; journal article · DOI 10.1021/acs.jmedchem.6b01309

Bibliografisk träff 2015-06-15

Anti-HIV screening for cell-penetrating peptides using chloroquine and identification of anti-HIV peptides derived from matrix proteins.

Mizuguchi T, Ohashi N, Nomura W, Komoriya M, Hashimoto C, Yamamoto N, Murakami T, Tamamura H.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2015.06.020

Bibliografisk träff 2012-09-24

Chemokine receptor antagonists.

Pease J, Horuk R.

J Med Chem · journal article · DOI 10.1021/jm300682j

Bibliografisk träff 2012-04-20

Pharmacophore-based small molecule CXCR4 ligands.

Narumi T, Tanaka T, Hashimoto C, Nomura W, Aikawa H, Sohma A, Itotani K, Kawamata M, Murakami T, Yamamoto N, Tamamura H.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2012.04.032

Bibliografisk träff 2012-01-02

Conjugation of cell-penetrating peptides leads to identification of anti-HIV peptides from matrix proteins.

Narumi T, Komoriya M, Hashimoto C, Wu H, Nomura W, Suzuki S, Tanaka T, Chiba J, Yamamoto N, Murakami T, Tamamura H.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2011.12.055

Bibliografisk träff 2011-05-20

Discovery of 4-[4-({(3R)-1-butyl-3-[(R)-cyclohexyl(hydroxy)methyl]-2,5-dioxo-1,4,9-triazaspiro[5.5]undec-9-yl}methyl)phenoxy]benzoic acid hydrochloride: a highly potent orally available CCR5 selective antagonist.

Nishizawa R, Nishiyama T, Hisaichi K, Minamoto C, Murota M, Takaoka Y, Nakai H, Tada H, Sagawa K, Shibayama S, Fukushima D, Maeda K, Mitsuya H.

Bioorg Med Chem · research-article; journal article · DOI 10.1016/j.bmc.2011.05.022

Bibliografisk träff 2010-12-28

Spirodiketopiperazine-based CCR5 antagonist: discovery of an antiretroviral drug candidate.

Nishizawa R, Nishiyama T, Hisaichi K, Minamoto C, Matsunaga N, Takaoka Y, Nakai H, Jenkinson S, Kazmierski WM, Tada H, Sagawa K, Shibayama S, Fukushima D, Maeda K, Mitsuya H.

Bioorg Med Chem Lett · research-article; journal article · DOI 10.1016/j.bmcl.2010.12.109

Bibliografisk träff 2010-12-03

An imidazopiperidine series of CCR5 antagonists for the treatment of HIV: the discovery of N-{(1S)-1-(3-fluorophenyl)-3-[(3-endo)-3-(5-isobutyryl-2-methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}acetamide (PF-232798).

Stupple PA, Batchelor DV, Corless M, Dorr PK, Ellis D, Fenwick DR, Galan SR, Jones RM, Mason HJ, Middleton DS, Perros M, Perruccio F, Platts MY, Pryde DC, Rodrigues D, Smith NN, Stephenson PT, Webster R, Westby M, Wood A.

J Med Chem · journal article · DOI 10.1021/jm100978n

Bibliografisk träff 2010-08-25

Discovery of INCB9471, a Potent, Selective, and Orally Bioavailable CCR5 Antagonist with Potent Anti-HIV-1 Activity.

Xue CB, Chen L, Cao G, Zhang K, Wang A, Meloni D, Glenn J, Anand R, Xia M, Kong L, Huang T, Feng H, Zheng C, Li M, Galya L, Zhou J, Shin N, Baribaud F, Solomon K, Scherle P, Zhao B, Diamond S, Emm T, Keller D, Contel N, Yeleswaram S, Vaddi K, Hollis G, Newton R, Friedman S, Metcalf B.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/ml1001536

Bibliografisk träff 2010-03-29

Effect of vicriviroc on the QT/corrected QT interval and central nervous system in healthy subjects.

O'Mara E, Kasserra C, Huddlestone JR, Wan Y, Soni P, Caceres M, Medlock M, Morrison R, Devinsky O.

Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; clinical trial, phase i; randomized controlled trial; journal article · DOI 10.1128/aac.01447-09

Bibliografisk träff 2009-05-18

The novel CXCR4 antagonist KRH-3955 is an orally bioavailable and extremely potent inhibitor of human immunodeficiency virus type 1 infection: comparative studies with AMD3100.

Murakami T, Kumakura S, Yamazaki T, Tanaka R, Hamatake M, Okuma K, Huang W, Toma J, Komano J, Yanaka M, Tanaka Y, Yamamoto N.

Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/aac.01727-08

Bibliografisk träff 2008-12-06

Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks.

Prado-Prado FJ, Martinez de la Vega O, Uriarte E, Ubeira FM, Chou KC, González-Díaz H.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2008.11.075

Bibliografisk träff 2005-03-01

New approaches toward anti-HIV chemotherapy.

De Clercq E.

J Med Chem · review; journal article · DOI 10.1021/jm040158k

Bibliografisk träff 2004-05-01

Piperazine-based CCR5 antagonists as HIV-1 inhibitors. IV. Discovery of 1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]- 4-[4-[2-methoxy-1(R)-4-(trifluoromethyl)phenyl]ethyl-3(S)-methyl-1-piperazinyl]- 4-methylpiperidine (Sch-417690/Sch-D), a potent, highly selective, and orally bioavailable CCR5 antagonist.

Tagat JR, McCombie SW, Nazareno D, Labroli MA, Xiao Y, Steensma RW, Strizki JM, Baroudy BM, Cox K, Lachowicz J, Varty G, Watkins R.

J Med Chem · journal article · DOI 10.1021/jm0304515

Bibliografisk träff 2003-02-01

Oximino-piperidino-piperidine-based CCR5 antagonists. Part 2: synthesis, SAR and biological evaluation of symmetrical heteroaryl carboxamides.

Palani A, Shapiro S, Clader JW, Greenlee WJ, Vice S, McCombie S, Cox K, Strizki J, Baroudy BM.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(02)01063-6