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Publikationer i urvalet

33 träffar

Bibliografisk träff 2023-10-10

PAR1 regulates sepsis-induced vascular endothelial barrier dysfunction by mediating ERM phosphorylation via the RhoA/ROCK signaling pathway.

Zhao L, Hu J, Zheng P, Mi B, Chen Z, Zhao X, Wu J, Wang Y.

Int Immunopharmacol · journal article · DOI 10.1016/j.intimp.2023.110992

Bibliografisk träff 2023-06-01

Thrombin increases the expression of cholesterol 25-hydroxylase in rat astrocytes after spinal cord injury.

Chen C, Ji H, Jiang N, Wang Y, Zhou Y, Zhu Z, Hu Y, Wang Y, Li A, Guo A.

Neural Regen Res · research-article; journal article · DOI 10.4103/1673-5374.357905

Bibliografisk träff 2022-12-20

Blood-nerve barrier disruption and coagulation system activation induced by mechanical compression injury participate in the peripheral sensitization of trigeminal neuralgia.

Zhou LX, Lin SW, Qiu RH, Lin L, Guo YF, Luo DS, Li YQ, Wang F.

Front Mol Neurosci · research-article; journal article · DOI 10.3389/fnmol.2022.1059980

Bibliografisk träff 2022-07-19

Activation of a Bacterial Mechanosensitive Channel, MscL, Underlies the Membrane Permeabilization of Dual-Targeting Antibacterial Compounds.

Wray R, Wang J, Blount P, Iscla I.

Antibiotics (Basel) · research-article; journal article · DOI 10.3390/antibiotics11070970

Bibliografisk träff 2022-05-24

Modulation of the Thrombin Pathway Restores LTP in a Pilocarpine Mice Model of Status Epilepticus.

Shavit-Stein E, Berkowitz S, Davidy T, Fennig U, Gofrit SG, Dori A, Maggio N.

Front Cell Neurosci · research-article; journal article · DOI 10.3389/fncel.2022.900925

Bibliografisk träff 2022-04-18

The suppression effect of SCH-79797 on <i>Streptococcus mutans</i> biofilm formation.

Zhang L, Shen Y, Qiu L, Yu F, Hu X, Wang M, Sun Y, Pan Y, Zhang K.

J Oral Microbiol · research-article; journal article · DOI 10.1080/20002297.2022.2061113

Bibliografisk träff 2022-01-11

PAR1, a therapeutic target for remote lung injury associated with hind limb ischemia/reperfusion: ERK5/KLF2-dependent lung capillary barrier preservation.

Kamel NM, El-Tanbouly DM, Abdallah DM, Sayed HM.

Chem Biol Interact · journal article · DOI 10.1016/j.cbi.2022.109809

Bibliografisk träff 2021-11-19

Thrombin induces pro-inflammatory and anti-inflammatory cytokines secretion from human mast cell line (HMC-1) via protease-activated receptors.

Fang X, Li M, Zhang W, Li J, Zhu T.

Mol Immunol · research support, non-u.s. gov't; journal article · DOI 10.1016/j.molimm.2021.11.012

Bibliografisk träff 2021-10-30

Coagulation Factor Xa Induces Proinflammatory Responses in Cardiac Fibroblasts via Activation of Protease-Activated Receptor-1.

D'Alessandro E, Scaf B, Munts C, van Hunnik A, Trevelyan CJ, Verheule S, Spronk HMH, Turner NA, Ten Cate H, Schotten U, van Nieuwenhoven FA.

Cells · research support, non-u.s. gov't; research-article; journal article · DOI 10.3390/cells10112958

Bibliografisk träff 2021-09-22

KLK8 promotes the proliferation and metastasis of colorectal cancer via the activation of EMT associated with PAR1.

Hua Q, Sun Z, Liu Y, Shen X, Zhao W, Zhu X, Xu P.

Cell Death Dis · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/s41419-021-04149-x

Bibliografisk träff 2020-07-29

Thrombin alters the synthesis and processing of CYR61/CCN1 in human corneal stromal fibroblasts and myofibroblasts through multiple distinct mechanisms.

Andreae EA, Warejcka DJ, Twining SS.

Mol Vis · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural

Bibliografisk träff 2020-06-04

Blockade of PAR-1 Signaling Attenuates Cardiac Hypertrophy and Fibrosis in Renin-Overexpressing Hypertensive Mice.

Yokono Y, Hanada K, Narita M, Tatara Y, Kawamura Y, Miura N, Kitayama K, Nakata M, Nozaka M, Kato T, Kudo N, Tsushima M, Toyama Y, Itoh K, Tomita H.

J Am Heart Assoc · research-article; journal article · DOI 10.1161/jaha.119.015616

Bibliografisk träff 2020-06-03

A Dual-Mechanism Antibiotic Kills Gram-Negative Bacteria and Avoids Drug Resistance.

Martin JK, Sheehan JP, Bratton BP, Moore GM, Mateus A, Li SH, Kim H, Rabinowitz JD, Typas A, Savitski MM, Wilson MZ, Gitai Z.

Cell · research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1016/j.cell.2020.05.005

Bibliografisk träff 2020-05-12

Brain Protease Activated Receptor 1 Pathway: A Therapeutic Target in the Superoxide Dismutase 1 (SOD1) Mouse Model of Amyotrophic Lateral Sclerosis.

Shavit-Stein E, Abu Rahal I, Bushi D, Gera O, Sharon R, Gofrit SG, Pollak L, Mindel K, Maggio N, Kloog Y, Chapman J, Dori A.

Int J Mol Sci · research-article; journal article · DOI 10.3390/ijms21103419

Bibliografisk träff 2020-01-01

The Synthetic Curcumin Derivative CNB-001 Attenuates Thrombin-Stimulated Microglial Inflammation by Inhibiting the ERK and p38 MAPK Pathways.

Akaishi T, Yamamoto S, Abe K.

Biol Pharm Bull · journal article · DOI 10.1248/bpb.b19-00699

Bibliografisk träff 2019-08-13

Triggering of protease-activated receptors (PARs) induces alternative M2 macrophage polarization with impaired plasticity.

García-González G, Sánchez-González A, Hernández-Bello R, González GM, Franco-Molina MA, Coronado-Cerda EE, Palma-Nicolás JP.

Mol Immunol · research support, non-u.s. gov't; journal article · DOI 10.1016/j.molimm.2019.08.004

Bibliografisk träff 2018-12-27

Thrombin contributes to the injury development and neurological deficit after acute subdural hemorrhage in rats only in collaboration with additional blood-derived factors.

Krämer TJ, Sakas W, Jussen D, Krenzlin H, Kempski O, Alessandri B.

BMC Neurosci · research support, non-u.s. gov't; research-article; journal article · DOI 10.1186/s12868-018-0481-5

Bibliografisk träff 2018-06-01

SCH79797 improves outcomes in experimental bacterial pneumonia by boosting neutrophil killing and direct antibiotic activity.

Gupta N, Liu R, Shin S, Sinha R, Pogliano J, Pogliano K, Griffin JH, Nizet V, Corriden R.

J Antimicrob Chemother · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1093/jac/dky033

Bibliografisk träff 2016-11-01

SCH 79797, a selective PAR1 antagonist, protects against ischemia/reperfusion-induced arrhythmias in the rat hearts.

Mohamed OY, Al-Masri AA, El Eter EA, Lateef R.

Eur Rev Med Pharmacol Sci · research support, non-u.s. gov't; journal article

Bibliografisk träff 2016-07-16

Expression of proteinase-activated receptor (PAR)-2 in monocytes from allergic patients and potential molecular mechanism.

Ge S, Li T, Yao Q, Yan H, Huiyun Z, Zheng Y, Zhang B, He S.

Cell Biol Toxicol · journal article · DOI 10.1007/s10565-016-9353-x

Bibliografisk träff 2016-02-29

Pravastatin and C reactive protein modulate protease- activated receptor-1 expression in vitro blood platelets.

Chu LX, Zhou SX, Yang F, Qin YQ, Liang ZS, Mo CG, Wang XD, Xie J, He LP.

Cell Mol Biol (Noisy-le-grand) · research support, non-u.s. gov't; journal article

Bibliografisk träff 2016-01-01

Cyclooxygenase-2 Inhibition Provides Lasting Protection Following Germinal Matrix Hemorrhage in Premature Infant Rats.

Lekic T, Krafft PR, Klebe D, Rolland WB, Flores J, Tang J, Zhang JH.

Acta Neurochir Suppl · journal article; research support, n.i.h., extramural · DOI 10.1007/978-3-319-18497-5_36

Bibliografisk träff 2016-01-01

PAR-1, -4, and the mTOR Pathway Following Germinal Matrix Hemorrhage.

Lekic T, Krafft PR, Klebe D, Flores J, Rolland WB, Tang J, Zhang JH.

Acta Neurochir Suppl · journal article; research support, n.i.h., extramural · DOI 10.1007/978-3-319-18497-5_38

Bibliografisk träff 2015-02-04

Interference with protease-activated receptor 1 does not reduce damage to subventricular zone cells of immature rodent brain following exposure to blood or blood plasma.

Mao X, Del Bigio MR.

J Negat Results Biomed · research support, non-u.s. gov't; research-article; journal article · DOI 10.1186/s12952-014-0022-4

Bibliografisk träff 2013-12-16

Induction of tumor necrosis factor (TNF) release from subtypes of T cells by agonists of proteinase activated receptors.

Yang H, Li T, Wei J, Zhang H, He S.

Mediators Inflamm · research support, non-u.s. gov't; research-article; journal article · DOI 10.1155/2013/165453

Bibliografisk träff 2013-04-17

Protease-activated receptor 1 inhibition by SCH79797 attenuates left ventricular remodeling and profibrotic activities of cardiac fibroblasts.

Sonin DL, Wakatsuki T, Routhu KV, Harmann LM, Petersen M, Meyer J, Strande JL.

J Cardiovasc Pharmacol Ther · research-article; journal article; research support, n.i.h., extramural · DOI 10.1177/1074248413485434

Bibliografisk träff 2013-03-28

Role of SCH79797 in maintaining vascular integrity in rat model of subarachnoid hemorrhage.

Yan J, Manaenko A, Chen S, Klebe D, Ma Q, Caner B, Fujii M, Zhou C, Zhang JH.

Stroke · research-article; journal article; research support, n.i.h., extramural · DOI 10.1161/strokeaha.113.678474

Bibliografisk träff 2012-10-23

The PAR1 antagonist, SCH79797, alters platelet morphology and function independently of PARs.

Lee H, Hamilton JR.

Thromb Haemost · letter; research support, non-u.s. gov't · DOI 10.1160/th12-06-0389

Bibliografisk träff 2012-09-19

PAR-1 antagonist SCH79797 ameliorates apoptosis following surgical brain injury through inhibition of ASK1-JNK in rats.

Manaenko A, Sun X, Kim CH, Yan J, Ma Q, Zhang JH.

Neurobiol Dis · research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.nbd.2012.09.004

Bibliografisk träff 2012-06-01

Inhibition of proinflammatory cytokines by SCH79797, a selective protease-activated receptor 1 antagonist, protects rat kidney against ischemia-reperfusion injury.

El Eter EA, Aldrees A.

Shock · research support, non-u.s. gov't; journal article · DOI 10.1097/shk.0b013e3182507774