Targeting autophagy drug discovery: Targets, indications and development trends.
Jiang M, Wu W, Xiong Z, Yu X, Ye Z, Wu Z.
Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2023.116117 PUBLIKATIONSREGISTRET
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Publikationer i urvalet
28 träffarDiscovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities.
Zhu H, Ying S, Zhou B, Liang X, He Q, Song P, Hu X, Shi K, Xiong M, Jin H, Pan Y.
Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2020.113117Methylsulfanylpyridine based diheteroaryl isocombretastatin analogs as potent anti-proliferative agents.
Álvarez R, Aramburu L, Gajate C, Vicente-Blázquez A, Mollinedo F, Medarde M, Peláez R.
Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2020.112933p62/SQSTM1, a Central but Unexploited Target: Advances in Its Physiological/Pathogenic Functions and Small Molecular Modulators.
Chen Y, Li Q, Li Q, Xing S, Liu Y, Liu Y, Chen Y, Liu W, Feng F, Sun H.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.9b02038Design, synthesis, and evaluation of N-phenyl-4-(2-phenylsulfonamido)-benzamides as microtubule-targeting agents in drug-resistant cancer cells, displaying HDAC inhibitory response.
Wu WC, Liu YM, Lin MH, Liao YH, Lai MJ, Chuang HY, Hung TY, Chen CH, Liou JP.
Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2020.112158Application of triazoles as bioisosteres and linkers in the development of microtubule targeting agents.
Malik MS, Ahmed SA, Althagafi II, Ansari MA, Kamal A, Kamal A.
RSC Med Chem · review-article; review; journal article · DOI 10.1039/c9md00458k1,2,3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships.
Xu Z, Zhao SJ, Liu Y.
Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2019.1117001-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase.
Lai MJ, Ojha R, Lin MH, Liu YM, Lee HY, Lin TE, Hsu KC, Chang CY, Chen MC, Nepali K, Chang JY, Liou JP.
Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2018.10.066Rational design and synthesis of 2-anilinopyridinyl-benzothiazole Schiff bases as antimitotic agents.
Shaik TB, Hussaini SMA, Nayak VL, Sucharitha ML, Malik MS, Kamal A.
Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2017.03.089Synthesis and Biological Evaluation of N-[2-(4-Hydroxyphenylamino)-pyridin-3-yl]-4-methoxy-benzenesulfonamide (ABT-751) Tricyclic Analogues as Antimitotic and Antivascular Agents with Potent in Vivo Antitumor Activity.
Segaoula Z, Leclercq J, Verones V, Flouquet N, Lecoeur M, Ach L, Renault N, Barczyk A, Melnyk P, Berthelot P, Thuru X, Lebegue N.
J Med Chem · journal article · DOI 10.1021/acs.jmedchem.6b00847Synthesis and biological evaluation of N(9)-substituted harmine derivatives as potential anticancer agents.
Du H, Tian S, Chen J, Gu H, Li N, Wang J.
Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2016.06.087Blocking Blood Flow to Solid Tumors by Destabilizing Tubulin: An Approach to Targeting Tumor Growth.
Pérez-Pérez MJ, Priego EM, Bueno O, Martins MS, Canela MD, Liekens S.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.6b00463Design and synthesis of cis-restricted benzimidazole and benzothiazole mimics of combretastatin A-4 as antimitotic agents with apoptosis inducing ability.
Ashraf M, Shaik TB, Malik MS, Syed R, Mallipeddi PL, Vardhan MVPSV, Kamal A.
Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2016.06.044Design, Synthesis, and Biological Evaluation of 1-Methyl-1,4-dihydroindeno[1,2-c]pyrazole Analogues as Potential Anticancer Agents Targeting Tubulin Colchicine Binding Site.
Liu YN, Wang JJ, Ji YT, Zhao GD, Tang LQ, Zhang CM, Guo XL, Liu ZP.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.6b00071N-Sulfonyl-aminobiaryls as Antitubulin Agents and Inhibitors of Signal Transducers and Activators of Transcription 3 (STAT3) Signaling.
Lai MJ, Lee HY, Chuang HY, Chang LH, Tsai AC, Chen MC, Huang HL, Wu YW, Teng CM, Pan SL, Liu YM, Mehndiratta S, Liou JP.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.5b00659Synthesis of 2-anilinopyridine dimers as microtubule targeting and apoptosis inducing agents.
Kamal A, Hussaini SM, Nayak VL, Malik MS, Sucharitha ML, Shaik TB, Ashraf M, Bagul C.
Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2014.11.001Synthesis and evaluation of N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)nicotinamides as potential anticancer agents that inhibit tubulin polymerization.
Kamal A, Reddy NV, Nayak VL, Bolla NR, Subba Rao AV, Prasad B.
Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2014.04.038Furanylazaindoles: potent anticancer agents in vitro and in vivo.
Lee HY, Pan SL, Su MC, Liu YM, Kuo CC, Chang YT, Wu JS, Nien CY, Mehndiratta S, Chang CY, Wu SY, Lai MJ, Chang JY, Liou JP.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm4011115Synthesis, antiproliferative activity and tubulin targeting effect of acridinone and dioxophenothiazine derivatives.
Verones V, Flouquet N, Lecoeur M, Lemoine A, Farce A, Baldeyrou B, Mahieu C, Wattez N, Lansiaux A, Goossens JF, Berthelot P, Lebegue N.
Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2012.10.051Identification of selective tubulin inhibitors as potential anti-trypanosomal agents.
Lama R, Sandhu R, Zhong B, Li B, Su B.
Bioorg Med Chem Lett · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2012.07.023Synthesis and pharmacological evaluation of N-(3-(1H-indol-4-yl)-5-(2-methoxyisonicotinoyl)phenyl)methanesulfonamide (LP-261), a potent antimitotic agent.
Shetty RS, Lee Y, Liu B, Husain A, Joseph RW, Lu Y, Nelson D, Mihelcic J, Chao W, Moffett KK, Schumacher A, Flubacher D, Stojanovic A, Bukhtiyarova M, Williams K, Lee KJ, Ochman AR, Saporito MS, Moore WR, Flynn GA, Dorsey BD, Springman EB, Fujimoto T, Kelly MJ.
J Med Chem · journal article · DOI 10.1021/jm100659vDiscovery of N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine, a potent apoptosis inducer and efficacious anticancer agent with high blood brain barrier penetration.
Sirisoma N, Pervin A, Zhang H, Jiang S, Willardsen JA, Anderson MB, Mather G, Pleiman CM, Kasibhatla S, Tseng B, Drewe J, Cai SX.
J Med Chem · journal article · DOI 10.1021/jm801315bSynthesis of novel diaryl ethers and their evaluation as antimitotic agents.
In JK, Lee MS, Yang JE, Kwak JH, Lee H, Boovanahalli SK, Lee K, Kim SJ, Moon SK, Lee S, Choi NS, Ahn SK, Jung JK.
Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2006.12.048Array-based structure and gene expression relationship study of antitumor sulfonamides including N-[2-[(4-hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide and N-(3-chloro-7-indolyl)-1,4-benzenedisulfonamide.
Owa T, Yokoi A, Yamazaki K, Yoshimatsu K, Yamori T, Nagasu T.
J Med Chem · journal article · DOI 10.1021/jm0201060Novel sulfonate derivatives: potent antimitotic agents.
Gwaltney SL, Imade HM, Li Q, Gehrke L, Credo RB, Warner RB, Lee JY, Kovar P, Frost D, Ng SC, Sham HL.
Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(01)00279-7A focused compound library of novel N-(7-indolyl)benzenesulfonamides for the discovery of potent cell cycle inhibitors.
Owa T, Okauchi T, Yoshimatsu K, Sugi NH, Ozawa Y, Nagasu T, Koyanagi N, Okabe T, Kitoh K, Yoshino H.
Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(00)00219-5Discovery of novel antitumor sulfonamides targeting G1 phase of the cell cycle.
Owa T, Yoshino H, Okauchi T, Yoshimatsu K, Ozawa Y, Sugi NH, Nagasu T, Koyanagi N, Kitoh K.
J Med Chem · journal article · DOI 10.1021/jm9902638Novel sulfonamides as potential, systemically active antitumor agents.
Yoshino H, Ueda N, Niijima J, Sugumi H, Kotake Y, Koyanagi N, Yoshimatsu K, Asada M, Watanabe T, Nagasu T.
J Med Chem · journal article · DOI 10.1021/jm00091a018