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Publikationer i urvalet

29 träffar

Bibliografisk träff 2024-06-17

Modulation of endogenous opioid signaling by inhibitors of puromycin-sensitive aminopeptidase.

Singh R, Jiang R, Williams J, Dobariya P, Hanak F, Xie J, Rothwell PE, Vince R, More SS.

Eur J Med Chem · research-article; journal article · DOI 10.1016/j.ejmech.2024.116604

Bibliografisk träff 2024-01-13

Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel.

Zhang SM, Paulin CBJ, Shu H, Yagüe-Capilla M, Michel M, Marttila P, Ortis F, Bwanika HC, Dirks C, Venkatram RP, Wiita E, Jemth AS, Almlöf I, Loseva O, Hormann FM, Koolmeister T, Linde E, Lee S, Llona-Minguez S, Haraldsson M, Axelsson H, Strömberg K, Homan EJ, Scobie M, Lundbäck T, Helleday T, Rudd SG.

iScience · research-article; journal article · DOI 10.1016/j.isci.2024.108907

Bibliografisk träff 2020-05-08

Molecular Basis for Omapatrilat and Sampatrilat Binding to Neprilysin-Implications for Dual Inhibitor Design with Angiotensin-Converting Enzyme.

Sharma U, Cozier GE, Sturrock ED, Acharya KR.

J Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/acs.jmedchem.0c00441

Bibliografisk träff 2020-03-18

A novel potent metal-binding NDM-1 inhibitor was identified by fragment virtual, SPR and NMR screening.

Guo H, Cheng K, Gao Y, Bai W, Wu C, He W, Li C, Li Z.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2020.115437

Bibliografisk träff 2018-12-03

Discovery of TD-0212, an Orally Active Dual Pharmacology AT<sub>1</sub> Antagonist and Neprilysin Inhibitor (ARNI).

McKinnell RM, Fatheree P, Choi SK, Gendron R, Jendza K, Olson Blair B, Budman J, Hill CM, Hegde LG, Yu C, McConn D, Hegde SS, Marquess DG, Klein U.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/acsmedchemlett.8b00462

Bibliografisk träff 2015-07-17

Modulation of disulfide dual ENKephalinase inhibitors (DENKIs) activity by a transient N-protection for pain alleviation by oral route.

Poras H, Bonnard E, Fournié-Zaluski MC, Roques BP.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2015.07.027

Bibliografisk träff 2015-04-13

Approved Drugs Containing Thiols as Inhibitors of Metallo-β-lactamases: Strategy To Combat Multidrug-Resistant Bacteria.

Klingler FM, Wichelhaus TA, Frank D, Cuesta-Bernal J, El-Delik J, Müller HF, Sjuts H, Göttig S, Koenigs A, Pos KM, Pogoryelov D, Proschak E.

J Med Chem · journal article · DOI 10.1021/jm501844d

Bibliografisk träff 2014-04-04

Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-β hydrolysis.

Charton J, Gauriot M, Guo Q, Hennuyer N, Marechal X, Dumont J, Hamdane M, Pottiez V, Landry V, Sperandio O, Flipo M, Buee L, Staels B, Leroux F, Tang WJ, Deprez B, Deprez-Poulain R.

Eur J Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1016/j.ejmech.2014.04.009

Tillbakadragen publikation 2011-06-24

Collateral sensitivity of multidrug-resistant cells to the orphan drug tiopronin.

Goldsborough AS, Handley MD, Dulcey AE, Pluchino KM, Kannan P, Brimacombe KR, Hall MD, Griffiths G, Gottesman MM.

J Med Chem · retracted publication; research support, n.i.h., intramural; research-article; journal article · DOI 10.1021/jm2001663

Bibliografisk träff 2009-06-21

Synthesis and enzymatic evaluation of novel partially fluorinated thiol dual ACE/NEP inhibitors.

Olimpieri F, Tambaro S, Fustero S, Lazzari P, Sanchez-Roselló M, Pani L, Volonterio A, Zanda M.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2009.06.064

Bibliografisk träff 2007-04-08

Chemical genetics reveals a complex functional ground state of neural stem cells.

Diamandis P, Wildenhain J, Clarke ID, Sacher AG, Graham J, Bellows DS, Ling EK, Ward RJ, Jamieson LG, Tyers M, Dirks PB.

Nat Chem Biol · research support, non-u.s. gov't; journal article · DOI 10.1038/nchembio873

Bibliografisk träff 2002-04-01

Development of new hydrogen-bond descriptors and their application to comparative molecular field analyses.

Böhm M, Klebe G.

J Med Chem · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1021/jm011039x

Bibliografisk träff 2002-03-01

Toward an optimal joint recognition of the S1' subsites of endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme (ACE), and neutral endopeptidase (NEP).

Inguimbert N, Coric P, Poras H, Meudal H, Teffot F, Fournié-Zaluski MC, Roques BP.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm0005454

Bibliografisk träff 2000-02-01

Protease inhibitors: current status and future prospects.

Leung D, Abbenante G, Fairlie DP.

J Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1021/jm990412m

Bibliografisk träff 2000-02-01

Potent and selective non-peptidic inhibitors of endothelin-converting enzyme-1 with sustained duration of action.

De Lombaert S, Blanchard L, Stamford LB, Tan J, Wallace EM, Satoh Y, Fitt J, Hoyer D, Simonsbergen D, Moliterni J, Marcopoulos N, Savage P, Chou M, Trapani AJ, Jeng AY.

J Med Chem · journal article · DOI 10.1021/jm990507o

Bibliografisk träff 1997-09-01

Validation of EGSITE2, a mixed integer program for deducing objective site models for experimental binding data.

Crippen GM.

J Med Chem · journal article · DOI 10.1021/jm970211n

Bibliografisk träff 1997-02-01

Ortho-substituted benzofused macrocyclic lactams as zinc metalloprotease inhibitors.

Ksander GM, de Jesus R, Yuan A, Ghai RD, Trapani A, McMartin C, Bohacek R.

J Med Chem · journal article · DOI 10.1021/jm960582o

Bibliografisk träff 1995-12-01

New alpha-thiol dipeptide dual inhibitors of angiotensin-I converting enzyme and neutral endopeptidase EC 3.4.24.11.

Fink CA, Qiao Y, Berry CJ, Sakane Y, Ghai RD, Trapani AJ.

J Med Chem · journal article · DOI 10.1021/jm00026a009

Bibliografisk träff 1995-06-01

Hydroxamic acids as potent inhibitors of endothelin-converting enzyme from human bronchiolar smooth muscle.

Bihovsky R, Levinson BL, Loewi RC, Erhardt PW, Polokoff MA.

J Med Chem · journal article · DOI 10.1021/jm00012a011

Bibliografisk träff 1995-05-01

Dicarboxylic acid dipeptide neutral endopeptidase inhibitors.

Ksander GM, Ghai RD, deJesus R, Diefenbacher CG, Yuan A, Berry C, Sakane Y, Trapani A.

J Med Chem · journal article · DOI 10.1021/jm00010a014

Bibliografisk träff 1994-06-01

New thiol inhibitors of neutral endopeptidase EC 3.4.24.11: synthesis and enzyme active-site recognition.

Gomez-Monterrey I, Beaumont A, Nemecek P, Roques BP, Fournie-Zaluski MC.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00038a016

Bibliografisk träff 1994-02-01

N-Phosphonomethyl dipeptides and their phosphonate prodrugs, a new generation of neutral endopeptidase (NEP, EC 3.4.24.11) inhibitors.

De Lombaert S, Erion MD, Tan J, Blanchard L, el-Chehabi L, Ghai RD, Sakane Y, Berry C, Trapani AJ.

J Med Chem · journal article · DOI 10.1021/jm00030a009

Bibliografisk träff 1993-11-01

Heterocyclic lactam derivatives as dual angiotensin converting enzyme and neutral endopeptidase 24.11 inhibitors.

Stanton JL, Sperbeck DM, Trapani AJ, Cote D, Sakane Y, Berry CJ, Ghai RD.

J Med Chem · journal article · DOI 10.1021/jm00076a010

Bibliografisk träff 1993-01-01

Exploration of neutral endopeptidase active site by a series of new thiol-containing inhibitors.

Gomez-Monterrey I, Turcaud S, Lucas E, Bruetschy L, Roques BP, Fournié-Zaluski MC.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00053a011

Bibliografisk träff 1992-05-01

Definition and display of steric, hydrophobic, and hydrogen-bonding properties of ligand binding sites in proteins using Lee and Richards accessible surface: validation of a high-resolution graphical tool for drug design.

Bohacek RS, McMartin C.

J Med Chem · journal article · DOI 10.1021/jm00088a002

Bibliografisk träff 1992-02-01

A novel class of enkephalinase inhibitors containing a C-terminal sulfo group.

Mimura T, Nakamura Y, Nishino J, Sawayama T, Komiya T, Deguchi T, Kita A, Nakamura H, Matsumoto J.

J Med Chem · journal article · DOI 10.1021/jm00081a024

Bibliografisk träff 1989-12-01

Enkephalinase inhibitors. 1. 2,4-Dibenzylglutaric acid derivatives.

Ksander GM, Diefenbacher CG, Yuan AM, Clark F, Sakane Y, Ghai RD.

J Med Chem · journal article · DOI 10.1021/jm00132a005

Bibliografisk träff 1985-09-01

Synthesis and biological evaluation of phosphonamidate peptide inhibitors of enkephalinase and angiotensin-converting enzyme.

Elliott RL, Marks N, Berg MJ, Portoghese PS.

J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00147a015

Bibliografisk träff 1985-09-01

New bidentates as full inhibitors of enkephalin-degrading enzymes: synthesis and analgesic properties.

Fournié-Zaluski MC, Coulaud A, Bouboutou R, Chaillet P, Devin J, Waksman G, Costentin J, Roques BP.

J Med Chem · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00147a007