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Publikationer i urvalet

50 träffar

Bibliografisk träff 2008-10-04

Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Santana L, González-Díaz H, Quezada E, Uriarte E, Yáñez M, Viña D, Orallo F.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm800656v

Bibliografisk träff 2008-09-05

N9-substituted 2,4-diaminoquinazolines: synthesis and biological evaluation of lipophilic inhibitors of pneumocystis carinii and toxoplasma gondii dihydrofolate reductase.

Gangjee A, Adair OO, Pagley M, Queener SF.

J Med Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/jm800694g

Bibliografisk träff 2008-08-05

Synthesis and discovery of high affinity folate receptor-specific glycinamide ribonucleotide formyltransferase inhibitors with antitumor activity.

Deng Y, Wang Y, Cherian C, Hou Z, Buck SA, Matherly LH, Gangjee A.

J Med Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/jm8003366

Bibliografisk träff 2008-07-08

The effect of 5-alkyl modification on the biological activity of pyrrolo[2,3-d]pyrimidine containing classical and nonclassical antifolates as inhibitors of dihydrofolate reductase and as antitumor and/or antiopportunistic infection agents.

Gangjee A, Jain HD, Queener SF, Kisliuk RL.

J Med Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/jm800244v

Bibliografisk träff 2008-04-21

Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.

Obach RS, Lombardo F, Waters NJ.

Drug Metab Dispos · journal article · DOI 10.1124/dmd.108.020479

Bibliografisk träff 2007-06-07

Design and synthesis of classical and nonclassical 6-arylthio-2,4-diamino-5-ethylpyrrolo[2,3-d]pyrimidines as antifolates.

Gangjee A, Zeng Y, Talreja T, McGuire JJ, Kisliuk RL, Queener SF.

J Med Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/jm070165j

Bibliografisk träff 2004-12-01

Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.

Matthews EJ, Kruhlak NL, Weaver JL, Benz RD, Contrera JF.

Curr Drug Discov Technol · journal article · DOI 10.2174/1570163043334794

Bibliografisk träff 2004-08-01

[Drug-induced liver injury; fourteenth updated edition of the bibliographic database of liver injuries and related drugs].

Biour M, Ben Salem C, Chazouillères O, Grangé JD, Serfaty L, Poupon R.

Gastroenterol Clin Biol · bibliography; journal article · DOI 10.1016/s0399-8320(04)95062-2

Bibliografisk träff 2004-07-01

Design, synthesis, and biological evaluation of 2,4-diamino-5-methyl-6-substituted-pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors.

Gangjee A, Lin X, Queener SF.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm0306327

Bibliografisk träff 2004-07-01

Structural studies on bioactive compounds. 39. Biological consequences of the structural modification of DHFR-inhibitory 2,4-diamino-6-(4-substituted benzylamino-3-nitrophenyl)-6-ethylpyrimidines ('benzoprims').

Richardson ML, Croughton KA, Matthews CS, Stevens MF.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm040785+

Bibliografisk träff 2004-05-01

Synthesis of 2,4-diamino-6-[2'-O-(omega-carboxyalkyl)oxydibenz[b,f]azepin-5-yl]methylpteridines as potent and selective inhibitors of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductase.

Rosowsky A, Fu H, Chan DC, Queener SF.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm030599o

Bibliografisk träff 2004-04-01

Preliminary in vitro studies on two potent, water-soluble trimethoprim analogues with exceptional species selectivity against dihydrofolate reductase from Pneumocystis carinii and Mycobacterium avium.

Forsch RA, Queener SF, Rosowsky A.

Bioorg Med Chem Lett · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1016/j.bmcl.2003.12.103

Bibliografisk träff 2003-11-01

Synthesis and biological evaluation of 2,4-diamino-6-(arylaminomethyl)pyrido[2,3-d]pyrimidines as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase and as antiopportunistic infection and antitumor agents.

Gangjee A, Adair OO, Queener SF.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm030312n

Bibliografisk träff 2003-07-01

Dihydrofolate reductase mutant with exceptional resistance to methotrexate but not to trimetrexate.

Pineda P, Kanter A, McIvor RS, Benkovic SJ, Rosowsky A, Wagner CR.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm034057i

Bibliografisk träff 2002-11-01

Synthesis of classical and nonclassical, partially restricted, linear, tricyclic 5-deaza antifolates.

Gangjee A, Zeng Y, McGuire JJ, Kisliuk RL.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm0202369

Bibliografisk träff 2001-08-01

Structural studies on bioactive compounds. 34. Design, synthesis, and biological evaluation of triazenyl-substituted pyrimethamine inhibitors of Pneumocystis carinii dihydrofolate reductase.

Chan DC, Laughton CA, Queener SF, Stevens MF.

J Med Chem · journal article · DOI 10.1021/jm0108698

Bibliografisk träff 2001-07-01

Design, synthesis, computational prediction, and biological evaluation of ester soft drugs as inhibitors of dihydrofolate reductase from Pneumocystis carinii.

Graffner-Nordberg M, Kolmodin K, Aqvist J, Queener SF, Hallberg A.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm010856u

Bibliografisk träff 2001-06-01

Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines.

Gangjee A, Vidwans A, Elzein E, McGuire JJ, Queener SF, Kisliuk RL.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm0100382

Bibliografisk träff 1999-11-01

Structure-based design of selective inhibitors of dihydrofolate reductase: synthesis and antiparasitic activity of 2, 4-diaminopteridine analogues with a bridged diarylamine side chain.

Rosowsky A, Cody V, Galitsky N, Fu H, Papoulis AT, Queener SF.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm990331q

Bibliografisk träff 1999-07-01

Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase inhibitors and antitumor agents: synthesis and biological activities of 2,4-diamino-5-methyl-6-[(monosubstituted anilino)methyl] pyrido[2,3-d]pyrimidines.

Gangjee A, Adair O, Queener SF.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm990079m

Bibliografisk träff 1998-11-01

6-Substituted 2,4-diaminopyrido[3,2-d]pyrimidine analogues of piritrexim as inhibitors of dihydrofolate reductase from rat liver, Pneumocystis carinii, and Toxoplasma gondii and as antitumor agents.

Gangjee A, Zhu Y, Queener SF.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm980206z

Bibliografisk träff 1998-08-01

Structure-based design and synthesis of lipophilic 2,4-diamino-6-substituted quinazolines and their evaluation as inhibitors of dihydrofolate reductases and potential antitumor agents.

Gangjee A, Vidwans AP, Vasudevan A, Queener SF, Kisliuk RL, Cody V, Li R, Galitsky N, Luft JR, Pangborn W.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm980081y

Bibliografisk träff 1998-04-01

Selective Pneumocystis carinii dihydrofolate reductase inhibitors: design, synthesis, and biological evaluation of new 2,4-diamino-5-substituted-furo[2,3-d]pyrimidines.

Gangjee A, Guo X, Queener SF, Cody V, Galitsky N, Luft JR, Pangborn W.

J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm970537w

Bibliografisk träff 1998-04-01

Synthesis and biological activities of tricyclic conformationally restricted tetrahydropyrido annulated furo[2,3-d]pyrimidines as inhibitors of dihydrofolate reductases.

Gangjee A, Elzein E, Queener SF, McGuire JJ.

J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm9705420

Bibliografisk träff 1998-03-01

2,4-Diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidine analogues of trimethoprim as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.

Rosowsky A, Papoulis AT, Queener SF.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm970614n

Bibliografisk träff 1997-09-01

Conformationally restricted analogues of trimethoprim: 2,6-diamino-8-substituted purines as potential dihydrofolate reductase inhibitors from Pneumocystis carinii and Toxoplasma gondii.

Gangjee A, Vasudevan A, Queener SF.

J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm970271t

Bibliografisk träff 1997-09-01

Nonclassical 2,4-diamino-5-aryl-6-ethylpyrimidine antifolates: activity as inhibitors of dihydrofolate reductase from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents.

Robson C, Meek MA, Grunwaldt JD, Lambert PA, Queener SF, Schmidt D, Griffin RJ.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm970055k

Bibliografisk träff 1997-06-01

Structural studies on bioactive compounds. 28. Selective activity of triazenyl-substituted pyrimethamine derivatives against Pneumocystis carinii dihydrofolate reductase.

Stevens MF, Phillip KS, Rathbone DL, O'Shea DM, Queener SF, Schwalbe CH, Lambert PA.

J Med Chem · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1021/jm970050n

Bibliografisk träff 1997-06-01

Synthesis and biological activities of conformationally restricted, tricyclic nonclassical antifolates as inhibitors of dihydrofolate reductases.

Gangjee A, Shi J, Queener SF.

J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm960693n

Bibliografisk träff 1997-03-01

Effect of N9-methylation and bridge atom variation on the activity of 5-substituted 2,4-diaminopyrrolo[2,3-d]pyrimidines against dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii.

Gangjee A, Mavandadi F, Queener SF.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm960717q