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53 hits

Bibliografisk träff 2024-09-24

Combination treatment with histone deacetylase and carbonic anhydrase 9 inhibitors shows therapeutic potential in experimental diffuse intrinsic pontine glioma.

Fujita N, Bondoc A, Simoes S, Ishida J, Taccone MS, Luck A, Srikanthan D, Siddaway R, Levine A, Sabha N, Krumholtz S, Kondo A, Arai H, Smith C, McDonald P, Hawkins C, Dedhar S, Rutka J.

Brain Tumor Pathol · journal article · DOI 10.1007/s10014-024-00493-w

Bibliografisk träff 2024-05-24

A new framework for novel analogues of pazopanib as potent and selective human carbonic anhydrase inhibitors: Design, repurposing rational, synthesis, crystallographic, in vivo and in vitro biological assessments.

Hefny SM, El-Moselhy TF, El-Din N, Ammara A, Angeli A, Ferraroni M, El-Dessouki AM, Shaldam MA, Yahya G, Al-Karmalawy AA, Supuran CT, Tawfik HO.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2024.116527

Bibliografisk träff 2024-05-23

Novel 2,4-Dichloro-5-sulfamoylbenzoic Acid Oxime Esters: First Studies as Potential Human Carbonic Anhydrase Inhibitors.

Kilbile JT, Sapkal SB, Renzi G, D'Agostino I, Cutarella L, Mori M, De Filippis B, Islam I, Massardi ML, Somenza E, Ronca R, Tamboli Y, Carta F, Supuran CT.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/acsmedchemlett.4c00206

Bibliografisk träff 2024-05-07

In-vitro and in-silico investigations of SLC-0111 hydrazinyl analogs as human carbonic anhydrase I, II, IX, and XII inhibitors.

Sharma V, Vats L, Giovannuzzi S, Mohan B, Supuran CT, Sharma PK.

Arch Pharm (Weinheim) · journal article · DOI 10.1002/ardp.202400157

Bibliografisk träff 2024-03-26

Benzenesulfonamide decorated dihydropyrimidin(thi)ones: carbonic anhydrase profiling and antiproliferative activity.

Aslan H, Renzi G, Angeli A, D'Agostino I, Ronca R, Massardi ML, Tavani C, Carradori S, Ferraroni M, Governa P, Manetti F, Carta F, Supuran CT.

RSC Med Chem · research-article; journal article · DOI 10.1039/d4md00101j

Bibliografisk träff 2024-02-01

pH regulators and their inhibitors in tumor microenvironment.

Liao S, Wu G, Xie Z, Lei X, Yang X, Huang S, Deng X, Wang Z, Tang G.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2024.116170

Bibliografisk träff 2023-09-07

Design and synthesis of sulfonamides incorporating a biotin moiety: Carbonic anhydrase inhibitory effects, antiproliferative activity and molecular modeling studies.

Begines P, Bonardi A, Nocentini A, Gratteri P, Giovannuzzi S, Ronca R, Tavani C, Luisa Massardi M, López Ó, Supuran CT.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2023.117467

Bibliografisk träff 2023-08-06

The CAIX inhibitor SLC-0111 exerts anti-cancer activity on gastric cancer cell lines and resensitizes resistant cells to 5-Fluorouracil, taxane-derived, and platinum-based drugs.

Andreucci E, Biagioni A, Peri S, Versienti G, Cianchi F, Staderini F, Antonuzzo L, Supuran CT, Olivo E, Pasqualini E, Messerini L, Massi D, Lulli M, Ruzzolini J, Peppicelli S, Bianchini F, Schiavone N, Calorini L, Magnelli L, Papucci L.

Cancer Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.canlet.2023.216338

Bibliografisk träff 2023-07-27

1,5-Diaryl-1,2,4-triazole Ureas as New SLC-0111 Analogues Endowed with Dual Carbonic Anhydrase and VEGFR-2 Inhibitory Activities.

Elsawi AE, Elbadawi MM, Nocentini A, Almahli H, Giovannuzzi S, Shaldam M, Salem R, Ibrahim TM, Abdel-Aziz HA, Supuran CT, Eldehna WM.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.3c00721

Bibliografisk träff 2023-06-01

Design and synthesis of 6-arylpyridine-tethered sulfonamides as novel selective inhibitors of carbonic anhydrase IX with promising antitumor features toward the human colorectal cancer.

Eldehna WM, Mohammed EE, Al-Ansary GH, Berrino E, Elbadawi MM, Ibrahim TM, Jaballah MY, Al-Rashood ST, Binjubair FA, Celik M, Nocentini A, Elbarbry FA, Sahin F, Abdel-Aziz HA, Supuran CT, Fares M.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2023.115538

Bibliografisk träff 2023-03-18

Differential CMS-Related Expression of Cell Surface Carbonic Anhydrases IX and XII in Colorectal Cancer Models-Implications for Therapy.

Rotermund A, Brandt S, Staege MS, Luetzkendorf J, Mueller LP, Mueller T.

Int J Mol Sci · research-article; journal article · DOI 10.3390/ijms24065797

Bibliografisk träff 2023-01-26

SLC-0111, an inhibitor of carbonic anhydrase IX, attenuates hepatoblastoma cell viability and migration.

Eloranta K, Pihlajoki M, Liljeström E, Nousiainen R, Soini T, Lohi J, Cairo S, Wilson DB, Parkkila S, Heikinheimo M.

Front Oncol · research-article; journal article · DOI 10.3389/fonc.2023.1118268

Bibliografisk träff 2022-12-01

Antiproliferative effects of sulphonamide carbonic anhydrase inhibitors C18, SLC-0111 and acetazolamide on bladder, glioblastoma and pancreatic cancer cell lines.

Mussi S, Rezzola S, Chiodelli P, Nocentini A, Supuran CT, Ronca R.

J Enzyme Inhib Med Chem · research-article; journal article · DOI 10.1080/14756366.2021.2004592

Bibliografisk träff 2022-12-01

Design and synthesis of benzothiazole-based SLC-0111 analogues as new inhibitors for the cancer-associated carbonic anhydrase isoforms IX and XII.

Al-Warhi T, Elbadawi MM, Bonardi A, Nocentini A, Al-Karmalawy AA, Aljaeed N, Alotaibi OJ, Abdel-Aziz HA, Supuran CT, Eldehna WM.

J Enzyme Inhib Med Chem · research-article; journal article · DOI 10.1080/14756366.2022.2124409

Bibliografisk träff 2022-04-27

Development of 4-((3-oxo-3-phenylpropyl)amino)benzenesulfonamide derivatives utilizing tail/dual-tail approaches as novel carbonic anhydrase inhibitors.

Elbadawi MM, Eldehna WM, Nocentini A, Somaa WR, Al-Rashood ST, Elkaeed EB, El Hassab MA, Abdel-Aziz HA, Supuran CT, Fares M.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2022.114412

Bibliografisk träff 2022-04-02

Inhibition of carbonic anhydrases IX/XII by SLC-0111 boosts cisplatin effects in hampering head and neck squamous carcinoma cell growth and invasion.

Sarnella A, Ferrara Y, Auletta L, Albanese S, Cerchia L, Alterio V, De Simone G, Supuran CT, Zannetti A.

J Exp Clin Cancer Res · research-article; journal article · DOI 10.1186/s13046-022-02345-x

Bibliografisk träff 2022-03-14

Perfusion-Based Bioreactor Culture and Isothermal Microcalorimetry for Preclinical Drug Testing with the Carbonic Anhydrase Inhibitor SLC-0111 in Patient-Derived Neuroblastoma.

Huo Z, Bilang R, Supuran CT, von der Weid N, Bruder E, Holland-Cunz S, Martin I, Muraro MG, Gros SJ.

Int J Mol Sci · research-article; journal article · DOI 10.3390/ijms23063128

Bibliografisk träff 2021-12-27

One-Pot Procedure for the Synthesis of Asymmetric Substituted Ureido Benzene Sulfonamides as Effective Inhibitors of Carbonic Anhydrase Enzymes.

Vannozzi G, Vullo D, Angeli A, Ferraroni M, Combs J, Lomelino C, Andring J, Mckenna R, Bartolucci G, Pallecchi M, Lucarini L, Sgambellone S, Masini E, Carta F, Supuran CT.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.1c01906

Bibliografisk träff 2021-11-27

Natural inspired ligustrazine-based SLC-0111 analogues as novel carbonic anhydrase inhibitors.

Elimam DM, Eldehna WM, Salem R, Bonardi A, Nocentini A, Al-Rashood ST, Elaasser MM, Gratteri P, Supuran CT, Allam HA.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2021.114008

Bibliografisk träff 2021-08-25

Natural inspired piperine-based sulfonamides and carboxylic acids as carbonic anhydrase inhibitors: Design, synthesis and biological evaluation.

Elimam DM, Elgazar AA, Bonardi A, Abdelfadil M, Nocentini A, El-Domany RA, Abdel-Aziz HA, Badria FA, Supuran CT, Eldehna WM.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2021.113800

Bibliografisk träff 2021-07-07

Structural Insights into <i>Schistosoma mansoni</i> Carbonic Anhydrase (SmCA) Inhibition by Selenoureido-Substituted Benzenesulfonamides.

Angeli A, Ferraroni M, Da'dara AA, Selleri S, Pinteala M, Carta F, Skelly PJ, Supuran CT.

J Med Chem · research support, non-u.s. gov't; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.1c00840

Bibliografisk träff 2021-06-16

Investigation of the protective effect of acetazolamide and SLC-0111 on carbon tetrachloride-induced toxicity in fruit fly.

Güneş E, Aydin H, Nizamlioğlu HF.

Toxicol Rep · research-article; journal article · DOI 10.1016/j.toxrep.2021.06.014

Bibliografisk träff 2021-03-15

Discovery of Potent Carbonic Anhydrase Inhibitors as Effective Anticonvulsant Agents: Drug Design, Synthesis, and In Vitro and In Vivo Investigations.

Mishra CB, Kumari S, Angeli A, Bua S, Mongre RK, Tiwari M, Supuran CT.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.0c01889

Bibliografisk träff 2021-03-13

Identification of N-phenyl-2-(phenylsulfonyl)acetamides/propanamides as new SLC-0111 analogues: Synthesis and evaluation of the carbonic anhydrase inhibitory activities.

Elbadawi MM, Eldehna WM, Nocentini A, Abo-Ashour MF, Elkaeed EB, Abdelgawad MA, Alharbi KS, Abdel-Aziz HA, Supuran CT, Gratteri P, Al-Sanea MM.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2021.113360

Bibliografisk träff 2021-02-18

Development of novel benzofuran-based SLC-0111 analogs as selective cancer-associated carbonic anhydrase isoform IX inhibitors.

Shaldam M, Eldehna WM, Nocentini A, Elsayed ZM, Ibrahim TM, Salem R, El-Domany RA, Capasso C, Abdel-Aziz HA, Supuran CT.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2021.113283

Bibliografisk träff 2021-02-01

Inhibition of Carbonic Anhydrase Using SLC-149: Support for a Noncatalytic Function of CAIX in Breast Cancer.

Mboge MY, Combs J, Singh S, Andring J, Wolff A, Tu C, Zhang Z, McKenna R, Frost SC.

J Med Chem · research-article; journal article · DOI 10.1021/acs.jmedchem.0c02077

Bibliografisk träff 2020-12-01

The Carbonic Anhydrase IX inhibitor SLC-0111 as emerging agent against the mesenchymal stem cell-derived pro-survival effects on melanoma cells.

Peppicelli S, Andreucci E, Ruzzolini J, Bianchini F, Nediani C, Supuran CT, Calorini L.

J Enzyme Inhib Med Chem · research-article; journal article · DOI 10.1080/14756366.2020.1764549

Bibliografisk träff 2020-10-15

Recent advances in the medicinal chemistry of carbonic anhydrase inhibitors.

Kumar S, Rulhania S, Jaswal S, Monga V.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2020.112923

Bibliografisk träff 2020-07-25

A comparative study of the binding modes of SLC-0111 and its analogues in the hCA II and hCA IX active sites using QM/MM, molecular docking, MM-GBSA and MD approaches.

Chahal V, Nirwan S, Kakkar R.

Biophys Chem · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1016/j.bpc.2020.106439

Bibliografisk träff 2020-07-01

A Phase 1 Study of SLC-0111, a Novel Inhibitor of Carbonic Anhydrase IX, in Patients With Advanced Solid Tumors.

McDonald PC, Chia S, Bedard PL, Chu Q, Lyle M, Tang L, Singh M, Zhang Z, Supuran CT, Renouf DJ, Dedhar S.

Am J Clin Oncol · research support, non-u.s. gov't; research-article; multicenter study; clinical trial, phase i; journal article · DOI 10.1097/coc.0000000000000691