Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein.
Adachi Y, Suzuki H, Sugiyama Y.
Pharm Res · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1023/a:1013358126640 PUBLICATION REGISTRY
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50 hitsA functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells.
Gao J, Murase O, Schowen RL, Aubé J, Borchardt RT.
Pharm Res · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1023/a:1011076217118Cytotoxic activity of some phenanthroindolizidine N-oxide alkaloids from Cynanchum vincetoxicum.
Staerk D, Christensen J, Lemmich E, Duus JO, Olsen CE, Jaroszewski JW.
J Nat Prod · journal article · DOI 10.1021/np0003443Reversal of anticancer drug resistance by macrolide antibiotics in vitro and in vivo.
Wang L, Kitaichi K, Hui CS, Takagi K, Takagi K, Sakai M, Yokogawa K, Miyamoto KI, Hasegawa T.
Clin Exp Pharmacol Physiol · journal article · DOI 10.1046/j.1440-1681.2000.03308.xTyrosine kinase inhibitors. 17. Irreversible inhibitors of the epidermal growth factor receptor: 4-(phenylamino)quinazoline- and 4-(phenylamino)pyrido[3,2-d]pyrimidine-6-acrylamides bearing additional solubilizing functions.
Smaill JB, Rewcastle GW, Loo JA, Greis KD, Chan OH, Reyner EL, Lipka E, Showalter HD, Vincent PW, Elliott WL, Denny WA.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm990482tSynthesis, spectroscopy, and cytotoxicity of glycosylated acetogenin derivatives as promising molecules for cancer therapy.
Queiroz EF, Roblot F, Duret P, Figadère B, Gouyette A, Laprévote O, Serani L, Hocquemiller R.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm990568mCloning and expression of murine sister of P-glycoprotein reveals a more discriminating transporter than MDR1/P-glycoprotein.
Lecureur V, Sun D, Hargrove P, Schuetz EG, Kim RB, Lan LB, Schuetz JD.
Mol Pharmacol · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1016/s0026-895x(24)26438-5Cellular pharmacokinetic aspects of reversal effect of itraconazole on P-glycoprotein-mediated resistance of anticancer drugs.
Takara K, Tanigawara Y, Komada F, Nishiguchi K, Sakaeda T, Okumura K.
Biol Pharm Bull · research support, non-u.s. gov't; journal article · DOI 10.1248/bpb.22.1355Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein and effect on cytochrome P-450 activities.
Dantzig AH, Shepard RL, Law KL, Tabas L, Pratt S, Gillespie JS, Binkley SN, Kuhfeld MT, Starling JJ, Wrighton SA.
J Pharmacol Exp Ther · journal article · DOI 10.1016/s0022-3565(24)34974-2A new bistetrahydrofuran acetogenin from the roots of Annona salzmanii.
Queiroz EF, Roblot F, Cavé A, Hocquemiller R, Serani L, Laprévote O, Paulo MQ.
J Nat Prod · research support, non-u.s. gov't; journal article · DOI 10.1021/np980482gP-glycoprotein inhibition by glibenclamide and related compounds.
Golstein PE, Boom A, van Geffel J, Jacobs P, Masereel B, Beauwens R.
Pflugers Arch · research support, non-u.s. gov't; journal article · DOI 10.1007/s004240050829A transfected cell model for the renal toxin transporter, rOCT2.
Pan BF, Sweet DH, Pritchard JB, Chen R, Nelson JA.
Toxicol Sci · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1093/toxsci/47.2.181New cyclic peptides from the ascidian Lissoclinum patella.
Fu X, Do T, Schmitz FJ, Andrusevich V, Engel MH.
J Nat Prod · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/np9802872Novel antineoplastic agents with efficacy against multidrug resistant tumor cells.
Medina JC, Shan B, Beckmann H, Farrell RP, Clark DL, Learned RM, Roche D, Li A, Baichwal V, Case C, Baeuerle PA, Rosen T, Jaen JC.
Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(98)00477-6Effect of modulators on the ATPase activity and vanadate nucleotide trapping of human P-glycoprotein.
Shepard RL, Winter MA, Hsaio SC, Pearce HL, Beck WT, Dantzig AH.
Biochem Pharmacol · journal article · DOI 10.1016/s0006-2952(98)00212-3Heterologous expression of various P-glycoproteins in polarized epithelial cells induces directional transport of small (type 1) and bulky (type 2) cationic drugs.
Smit JW, Weert B, Schinkel AH, Meijer DK.
J Pharmacol Exp Ther · journal article · DOI 10.1016/s0022-3565(24)37590-1Oxidations of vincristine catalyzed by peroxidase and ceruloplasmin.
Ahn SH, Duffel MW, Rosazza JP.
J Nat Prod · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/np970226oInhibition of tubulin polymerization by 5,6-dihydroindolo[2,1-alpha]isoquinoline derivatives.
Goldbrunner M, Loidl G, Polossek T, Mannschreck A, von Angerer E.
J Med Chem · journal article · DOI 10.1021/jm970177cStructure-activity relationships of diverse Annonaceous acetogenins against multidrug resistant human mammary adenocarcinoma (MCF-7/Adr) cells.
Oberlies NH, Chang CJ, McLaughlin JL.
J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm9700169Reversal of P-glycoprotein-associated multidrug resistance by ivermectin.
Pouliot JF, L'Heureux F, Liu Z, Prichard RK, Georges E.
Biochem Pharmacol · research support, non-u.s. gov't; journal article · DOI 10.1016/s0006-2952(96)00656-9Cell-based screen for identification of inhibitors of tubulin polymerization.
Kokoshka JM, Ireland CM, Barrows LR.
J Nat Prod · research support, u.s. gov't, p.h.s.; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/np960144kRanking of P-glycoprotein substrates and inhibitors by a calcein-AM fluorometry screening assay.
Tiberghien F, Loor F.
Anticancer Drugs · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1097/00001813-199607000-00012ATP-dependent 17 beta-estradiol 17-(beta-D-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroids.
Loe DW, Almquist KC, Cole SP, Deeley RG.
J Biol Chem · research support, non-u.s. gov't; journal article · DOI 10.1074/jbc.271.16.9683Competition of hydrophobic peptides, cytotoxic drugs, and chemosensitizers on a common P-glycoprotein pharmacophore as revealed by its ATPase activity.
Borgnia MJ, Eytan GD, Assaraf YG.
J Biol Chem · research support, non-u.s. gov't; journal article · DOI 10.1074/jbc.271.6.3163High-affinity inhibitors of dihydrofolate reductase: antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with small molecular size.
Kuyper LF, Baccanari DP, Jones ML, Hunter RN, Tansik RL, Joyner SS, Boytos CM, Rudolph SK, Knick V, Wilson HR, Caddell JM, Friedman HS, Comley JC, Stables JN.
J Med Chem · comparative study; journal article · DOI 10.1021/jm9505122Novel inhibitors for multidrug resistance: 1,3,5-triazacycloheptanes.
Sawanishi H, Wakusawa S, Murakami R, Muramatsu H, Suzuki H, Takashima A, Aizawa T, Miyamoto K.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00026a014An antimitotic and cytotoxic chalcone from Fissistigma lanuginosum.
Alias Y, Awang K, Hadi AH, Thoison O, Sévenet T, Païs M.
J Nat Prod · journal article · DOI 10.1021/np50122a002Indole alkaloids from Peschiera laeta that enhance vinblastine-mediated cytotoxicity with multidrug-resistant cells.
You M, Ma X, Mukherjee R, Farnsworth NR, Cordell GA, Kinghorn AD, Pezzuto JM.
J Nat Prod · comparative study; research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/np50113a007Antimitotic and cytotoxic flavonols from Zieridium pseudobtusifolium and Acronychia porteri.
Lichius JJ, Thoison O, Montagnac A, Païs M, Guéritte-Voegelein F, Sévenet T, Cosson JP, Hadi AH.
J Nat Prod · journal article · DOI 10.1021/np50109a024Design of antineoplastic agents on the basis of the "2-phenylnaphthalene-type" structural pattern. 2. Synthesis and biological activity studies of benzo]b]naphtho[2,3-d]furan-6,11-dione derivatives.
Cheng CC, Dong Q, Liu DF, Luo YL, Liu LF, Chen AY, Yu C, Savaraj N, Chou TC.
J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00077a016