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Publications in the selection

138 hits

Bibliografisk träff 2005-03-01

Design and synthesis of a potent macrocyclic 1,6-naphthyridine anti-human cytomegalovirus (HCMV) inhibitors.

Falardeau G, Lachance H, St-Pierre A, Yannopoulos CG, Drouin M, Bédard J, Chan L.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2005.01.050

Bibliografisk träff 2005-02-01

Synthesis, X-ray crystal structure study, and cytostatic and antiviral evaluation of the novel cycloalkyl-N-aryl-hydroxamic acids.

Barbarić M, Ursić S, Pilepić V, Zorc B, Hergold-Brundić A, Nagl A, Grdisa M, Pavelić K, Snoeck R, Andrei G, Balzarini J, De Clercq E, Mintas M.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm040878r

Bibliografisk träff 2005-01-01

Nucleotides and pronucleotides of 2,2-bis(hydroxymethyl)methylenecyclopropane analogues of purine nucleosides: synthesis and antiviral activity.

Yan Z, Kern ER, Gullen E, Cheng YC, Drach JC, Zemlicka J.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm040149b

Bibliografisk träff 2005-01-01

Synthesis and antiviral evaluation of cis-substituted cyclohexenyl and cyclohexanyl nucleosides.

Barral K, Courcambeck J, Pèpe G, Balzarini J, Neyts J, De Clercq E, Camplo M.

J Med Chem · journal article · DOI 10.1021/jm0493966

Bibliografisk träff 2005-01-01

The novel L- and D-amino acid derivatives of hydroxyurea and hydantoins: synthesis, X-ray crystal structure study, and cytostatic and antiviral activity evaluations.

Opacić N, Barbarić M, Zorc B, Cetina M, Nagl A, Frković D, Kralj M, Pavelić K, Balzarini J, Andrei G, Snoeck R, De Clercq E, Raić-Malić S, Mintas M.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm040869i

Bibliografisk träff 2005-01-01

Exploring the role of different drug transport routes in permeability screening.

Matsson P, Bergström CA, Nagahara N, Tavelin S, Norinder U, Artursson P.

J Med Chem · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1021/jm049711o

Bibliografisk träff 2004-12-01

(Z)- and (E)-[2-Fluoro-2-(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines, a new class of methylenecyclopropane analogues of nucleosides: synthesis and antiviral activity.

Zhou S, Kern ER, Gullen E, Cheng YC, Drach JC, Matsumi S, Mitsuya H, Zemlicka J.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm040093l

Bibliografisk träff 2004-11-01

Synthesis and antiviral evaluation of polyhalogenated imidazole nucleosides: dimensional analogues of 2,5,6-trichloro-1-(beta-D-ribofuranosyl)benzimidazole.

Chien TC, Saluja SS, Drach JC, Townsend LB.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm040016q

Bibliografisk träff 2004-11-01

Design, synthesis, and antiviral activity of certain 3-substituted 2,5,6-trichloroindole nucleosides.

Williams JD, Chen JJ, Drach JC, Townsend LB.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm0400146

Bibliografisk träff 2004-11-01

Synthesis and antiviral activity of 3-formyl- and 3-cyano-2,5,6-trichloroindole nucleoside derivatives.

Williams JD, Chen JJ, Drach JC, Townsend LB.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm040032n

Bibliografisk träff 2004-11-01

Synthesis, antiviral activity, and mode of action of some 3-substituted 2,5,6-trichloroindole 2'- and 5'-deoxyribonucleosides.

Williams JD, Ptak RG, Drach JC, Townsend LB.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm0400606

Bibliografisk träff 2004-10-01

6-azapyrimidine-2'-deoxy-4'-thionucleosides: antiviral agents against TK+ and TK- HSV and VZV strains.

Maslen HL, Hughes D, Hursthouse M, De Clercq E, Balzarini J, Simons C.

J Med Chem · journal article · DOI 10.1021/jm049806q

Bibliografisk träff 2004-05-01

Synthesis and anti-HCMV activity of 1-acyl-beta-lactams and 1-acylazetidines derived from phenylalanine.

Gerona-Navarro G, Pérez de Vega MJ, García-López MT, Andrei G, Snoeck R, Balzarini J, De Clercq E, González-Muñiz R.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2004.02.010

Bibliografisk träff 2004-03-01

Discovery of a new family of inhibitors of human cytomegalovirus (HCMV) based upon lipophilic alkyl furano pyrimidine dideoxy nucleosides: action via a novel non-nucleosidic mechanism.

McGuigan C, Pathirana RN, Snoeck R, Andrei G, De Clercq E, Balzarini J.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm030857h

Bibliografisk träff 2004-01-01

Synthesis and antiviral activity of (Z)- and (E)-2,2-[bis(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines: second-generation methylenecyclopropane analogues of nucleosides.

Zhou S, Breitenbach JM, Borysko KZ, Drach JC, Kern ER, Gullen E, Cheng YC, Zemlicka J.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm030316s

Bibliografisk träff 2003-12-01

Synthesis and antiviral evaluation of 3-hydroxy-2-methylpyridin-4-one dideoxynucleoside derivatives.

Barral K, Hider RC, Balzarini J, Neyts J, De Clercq E, Camplo M.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2003.09.033

Bibliografisk träff 2003-12-01

Novel bicyclic furanopyrimidines with dual anti-VZV and -HCMV activity.

McGuigan C, Brancale A, Andrei G, Snoeck R, De Clercq E, Balzarini J.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2003.08.028

Bibliografisk träff 2003-11-01

Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine.

Russ P, Schelling P, Scapozza L, Folkers G, Clercq ED, Marquez VE.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm030241s

Bibliografisk träff 2003-10-01

Design and synthesis of pyrrolidine-5,5'-trans-lactams (5-oxo-hexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 4. Antiviral activity and plasma stability.

Borthwick AD, Davies DE, Ertl PF, Exall AM, Haley TM, Hart GJ, Jackson DL, Parry NR, Patikis A, Trivedi N, Weingarten GG, Woolven JM.

J Med Chem · comparative study; journal article · DOI 10.1021/jm030810w

Bibliografisk träff 2003-05-01

Antiviral amphipathic oligo- and polyribonucleotides: analogue development and biological studies.

Hyde RM, Broom AD, Buckheit RW.

J Med Chem · journal article · DOI 10.1021/jm0203276

Bibliografisk träff 2002-12-01

A thymidine phosphorylase-stable analogue of BVDU with significant antiviral activity.

Guenther S, Balzarini J, De Clercq E, Nair V.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm025569k

Bibliografisk träff 2002-11-01

Synthesis and biological activity of strongly fluorescent tricyclic analogues of acyclovir and ganciclovir.

Goslinski T, Golankiewicz B, De Clercq E, Balzarini J.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm020827z

Bibliografisk träff 2002-05-01

Design and synthesis of novel 5-substituted acyclic pyrimidine nucleosides as potent and selective inhibitors of hepatitis B virus.

Kumar R, Nath M, Tyrrell DL.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm010410d

Bibliografisk träff 2002-03-01

New 2-(1-adamantylcarbonyl)pyridine and 1-acetyladamantane thiosemicarbazones-thiocarbonohydrazones: cell growth inhibitory, antiviral and antimicrobial activity evaluation.

Kolocouris A, Dimas K, Pannecouque C, Witvrouw M, Foscolos GB, Stamatiou G, Fytas G, Zoidis G, Kolocouris N, Andrei G, Snoeck R, De Clercq E.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/s0960-894x(01)00838-1

Bibliografisk träff 2002-02-01

5-Bromo (or chloro)-6-azido-5,6-dihydro-2' -deoxyuridine and -thymidine derivatives with potent antiviral activity.

Kumar R.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/s0960-894x(01)00735-1

Bibliografisk träff 2002-01-01

Rational determination of transfer free energies of small drugs across the water-oil interface.

Bas D, Dorison-Duval D, Moreau S, Bruneau P, Chipot C.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm010289a

Bibliografisk träff 2001-11-01

Novel 5-vinyl pyrimidine nucleosides with potent anti-hepatitis B virus activity.

Kumar R, Tyrrell DL.

Bioorg Med Chem Lett · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1016/s0960-894x(01)00589-3

Bibliografisk träff 2001-11-01

Synthesis and antiviral activity of novel acyclic nucleoside analogues of 5-(1-azido-2-haloethyl)uracils.

Kumar R, Sharma N, Nath M, Saffran HA, Tyrrell DL.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm010227k

Bibliografisk träff 2001-11-01

Fluorescent tricyclic analogues of acyclovir and ganciclovir. A structure-antiviral activity study.

Golankiewicz B, Ostrowski T, Goslinski T, Januszczyk P, Zeidler J, Baranowski D, de Clercq E.

J Med Chem · journal article · DOI 10.1021/jm010922s

Bibliografisk träff 2001-10-01

Synthesis and antiviral activity of novel 5-(1-cyanamido-2-haloethyl) and 5-(1-hydroxy(or methoxy)-2-azidoethyl) analogues of uracil nucleosides.

Kumar R, Rai D, Sharma SK, Sharma SK, Saffran HA, Blush R, Tyrrell DL.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm010226s