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Publications in the selection

50 hits

Bibliografisk träff 2006-11-10

Lead discovery and optimization of T-type calcium channel blockers.

Park JH, Choi JK, Lee E, Lee JK, Rhim H, Seo SH, Kim Y, Doddareddy MR, Pae AN, Kang J, Roh EJ.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2006.11.004

Bibliografisk träff 2006-10-30

3D pharmacophore based virtual screening of T-type calcium channel blockers.

Doddareddy MR, Choo H, Cho YS, Rhim H, Koh HY, Lee JH, Jeong SW, Pae AN.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2006.10.013

Bibliografisk träff 2006-10-21

Design, synthesis, and biological evaluation of 1,3-dioxoisoindoline-5-carboxamide derivatives as T-type calcium channel blockers.

Kim HS, Kim Y, Doddareddy MR, Seo SH, Rhim H, Tae J, Pae AN, Choo H, Cho YS.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2006.10.042

Bibliografisk träff 2006-10-12

Synthesis and biological evaluation of novel T-type calcium channel blockers.

Choi JY, Seo HN, Lee MJ, Park SJ, Park SJ, Jeon JY, Kang JH, Pae AN, Rhim H, Lee JY.

Bioorg Med Chem Lett · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2006.10.024

Bibliografisk träff 2006-10-10

Novel T-type calcium channel blockers: dioxoquinazoline carboxamide derivatives.

Jo MN, Seo HJ, Kim Y, Seo SH, Rhim H, Cho YS, Cha JH, Koh HY, Choo H, Pae AN.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2006.09.051

Bibliografisk träff 2006-07-28

Morpholin-2-one derivatives as novel selective T-type Ca2+ channel blockers.

Ku IW, Cho S, Doddareddy MR, Jang MS, Keum G, Lee JH, Chung BY, Kim Y, Rhim H, Kang SB.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2006.05.031

Bibliografisk träff 2005-10-01

Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.

Fontana E, Dansette PM, Poli SM.

Curr Drug Metab · systematic review; journal article · DOI 10.2174/138920005774330639

Bibliografisk träff 2005-06-01

A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.

Tobita M, Nishikawa T, Nagashima R.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2005.03.080

Bibliografisk träff 2005-03-01

A two-state homology model of the hERG K+ channel: application to ligand binding.

Rajamani R, Tounge BA, Li J, Reynolds CH.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2005.01.008

Bibliografisk träff 2005-01-01

Synthesis and biological activity of 3,4-dihydroquinazolines for selective T-type Ca2+ channel blockers.

Rhim H, Lee YS, Park SJ, Chung BY, Lee JY.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2004.10.078

Bibliografisk träff 2004-09-01

The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents.

Du LP, Tsai KC, Li MY, You QD, Xia L.

Bioorg Med Chem Lett · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2004.06.070

Bibliografisk träff 2004-07-01

3,4-Dihydroquinazoline derivatives as novel selective T-type Ca2+ channel blockers.

Lee YS, Lee BH, Park SJ, Kang SB, Rhim H, Park JY, Lee JH, Jeong SW, Lee JY.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2004.04.090

Bibliografisk träff 2004-03-01

Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies.

Nagy H, Goda K, Fenyvesi F, Bacsó Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabó G.

Biochem Biophys Res Commun · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bbrc.2004.01.156

Bibliografisk träff 2003-08-01

Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.

Keserü GM.

Bioorg Med Chem Lett · comparative study; journal article · DOI 10.1016/s0960-894x(03)00492-x

Bibliografisk träff 2003-04-01

Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery.

Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J.

J Med Chem · comparative study; validation study; journal article · DOI 10.1021/jm021012t

Bibliografisk träff 2002-08-01

Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers.

Cavalli A, Poluzzi E, De Ponti F, Recanatini M.

J Med Chem · journal article · DOI 10.1021/jm0208875

Bibliografisk träff 2002-05-01

Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein.

Ekins S, Kim RB, Leake BF, Dantzig AH, Schuetz EG, Lan LB, Yasuda K, Shepard RL, Winter MA, Schuetz JD, Wikel JH, Wrighton SA.

Mol Pharmacol · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1124/mol.61.5.964

Bibliografisk träff 2000-08-01

Mibefradil is a P-glycoprotein substrate and a potent inhibitor of both P-glycoprotein and CYP3A in vitro.

Wandel C, Kim RB, Guengerich FP, Wood AJ.

Drug Metab Dispos · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1016/s0090-9556(24)15160-4

Bibliografisk träff 2000-06-01

QSAR model for drug human oral bioavailability.

Yoshida F, Topliss JG.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm0000564

Bibliografisk träff 1999-12-01

Combining in vitro and in vivo pharmacokinetic data for prediction of hepatic drug clearance in humans by artificial neural networks and multivariate statistical techniques.

Schneider G, Coassolo P, Lavé T.

J Med Chem · journal article · DOI 10.1021/jm991030j