Preparation and anticonvulsant activity of a series of functionalized alpha-aromatic and alpha-heteroaromatic amino acids.
Kohn H, Sawhney KN, LeGall P, Conley JD, Robertson DW, Leander JD.
J Med Chem · journal article · DOI 10.1021/jm00165a006 PUBLICATION REGISTRY
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52 hitsSynthesis and anticonvulsant activity of 2-benzylglutarimides.
Goehring RR, Greenwood TD, Nwokogu GC, Pisipati JS, Rogers TG, Wolfe JF.
J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00165a007Synthesis and anticonvulsant activity of some new 2-substituted 3-aryl-4(3H)-quinazolinones.
Wolfe JF, Rathman TL, Sleevi MC, Campbell JA, Greenwood TD.
J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00163a027Metabolism of 3-(p-chlorophenyl)pyrrolidine. Structural effects in conversion of a prototype gamma-aminobutyric acid prodrug to lactam and gamma-aminobutyric acid type metabolites.
Wall GM, Baker JK.
J Med Chem · comparative study; journal article · DOI 10.1021/jm00126a033Triazolines. 14. 1,2,3-Triazolines and triazoles, a new class of anticonvulsants. Drug design and structure-activity relationships.
Kadaba PK.
J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00396a032The role of solvent-accessible surface area in determining partition coefficients.
Dunn WJ, Koehler MG, Grigoras S.
J Med Chem · journal article · DOI 10.1021/jm00390a002Substituted 1,3,4-thiadiazoles with anticonvulsant activity. 3. Guanidines.
Chapleo CB, Myers PL, Smith AC, Tulloch IF, Turner S, Walter DS.
J Med Chem · comparative study; journal article · DOI 10.1021/jm00388a038Functionalized DL-amino acid derivatives. Potent new agents for the treatment of epilepsy.
Conley JD, Kohn H.
J Med Chem · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00386a021Drugs as allergens: the molecular basis of IgE binding to thiopentone.
Harle DG, Baldo BA, Smal MA, Fisher MM.
Int Arch Allergy Appl Immunol · research support, non-u.s. gov't; journal article · DOI 10.1159/000234435Substituted 1,3,4-thiadiazoles with anticonvulsant activity. 1. Hydrazines.
Chapleo CB, Myers M, Myers PL, Saville JF, Smith AC, Stillings MR, Tulloch IF, Walter DS, Welbourn AP.
J Med Chem · journal article · DOI 10.1021/jm00161a024Substituted 1,3,4-thiadiazoles with anticonvulsant activity. 2. Aminoalkyl derivatives.
Stillings MR, Welbourn AP, Walter DS.
J Med Chem · journal article · DOI 10.1021/jm00161a025Anticonvulsant activity of piperidinol and (dialkylamino)alkanol esters.
Waters JA, Hollingsworth EB, Daly JW, Lewandowski G, Creveling CR.
J Med Chem · journal article · DOI 10.1021/jm00158a032Anticonvulsant activity of 2- and 3-aminobenzanilides.
Clark CR, Lin CM, Sansom RT.
J Med Chem · journal article · DOI 10.1021/jm00158a038Synthesis and activity of 6-aryl-3-(hydroxypolymethyleneamino)pyridazines in animal models of epilepsy.
Hallot A, Brodin R, Merlier J, Brochard J, Chambon JP, Biziere K.
J Med Chem · journal article · DOI 10.1021/jm00153a011N-imidazolylchroman-4-ones, N-imidazolyl-1-tetralones, and their alcohols as hypolipemic agents raising high-density lipoproteins.
Cozzi P, Branzoli U, Lovisolo PP, Orsini G, Carganico G, Pillan A, Chiari A.
J Med Chem · journal article · DOI 10.1021/jm00153a016Anticonvulsant activity of some 4-aminobenzanilides.
Clark CR, Sansom RT, Lin CM, Norris GN.
J Med Chem · comparative study; journal article · DOI 10.1021/jm00147a024[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
McNeal ET, Lewandowski GA, Daly JW, Creveling CR.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00381a019Anticonvulsant activity of some 4-aminobenzamides.
Clark CR, Wells MJ, Sansom RT, Norris GN, Dockens RC, Ravis WR.
J Med Chem · journal article · DOI 10.1021/jm00372a013Synthesis and central nervous system properties of 2-[(alkoxycarbonyl)amino]-4(5)-phenyl-2-imidazolines.
Weinhardt K, Beard CC, Dvorak C, Marx M, Patterson J, Roszkowski A, Schuler M, Unger SH, Wagner PJ, Wallach MB.
J Med Chem · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00371a011A simplified high-pressure liquid chromatography method for determining lipophilicity for structure-activity relationships.
Brent DA, Sabatka JJ, Minick DJ, Henry DW.
J Med Chem · journal article · DOI 10.1021/jm00361a0141-(Naphthylalkyl)-1H-imidazole derivatives, a new class of anticonvulsant agents.
Walker KA, Wallach MB, Hirschfeld DR.
J Med Chem · journal article · DOI 10.1021/jm00133a015Accumulation of drugs by guinea pig isolated atria. Quantitative correlations.
Lüllmann H, Timmermans PB, Weikert GM, Ziegler A.
J Med Chem · journal article · DOI 10.1021/jm00179a017