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138 hits

Bibliografisk träff 2001-08-01

Synthesis of N-alkyl substituted indolocarbazoles as potent inhibitors of human cytomegalovirus replication.

Slater MJ, Baxter R, Bonser RW, Cockerill S, Gohil K, Parry N, Robinson E, Randall R, Yeates C, Snowden W, Walters A.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(01)00352-3

Bibliografisk träff 2001-08-01

Design, synthesis, DNA binding, and biological evaluation of water-soluble hybrid molecules containing two pyrazole analogues of the alkylating cyclopropylpyrroloindole (CPI) subunit of the antitumor agent CC-1065 and polypyrrole minor groove binders.

Baraldi PG, Balboni G, Pavani MG, Spalluto G, Tabrizi MA, Clercq ED, Balzarini J, Bando T, Sugiyama H, Romagnoli R.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm0108404

Bibliografisk träff 2001-08-01

Synthesis, mechanism of action, and antiviral activity of a new series of covalent mechanism-based inhibitors of S-adenosyl-L-homocysteine hydrolase.

Guillerm G, Guillerm D, Vandenplas-Witkowki C, Rogniaux H, Carte N, Leize E, Van Dorsselaer A, De Clercq E, Lambert C.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm0108350

Bibliografisk träff 2001-06-01

The cyclohexene ring as bioisostere of a furanose ring: synthesis and antiviral activity of cyclohexenyl nucleosides.

Herdewijn P, De Clercq E.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(01)00270-0

Bibliografisk träff 2001-03-01

Syntheses and structure--activity relationships of novel apio and thioapio dideoxydidehydronucleosides as anti-HCMV agents.

Jeong LS, Kim HO, Moon HR, Hong JH, Yoo SJ, Choi WJ, Chun MW, Lee CK.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm000342f

Bibliografisk träff 2001-02-01

Synthesis and antiviral activity of novel D- and L-2'-azido-2',3'-dideoxyribofuranosyl-4'-thiopyrimidines and purines.

Kim HO, Kim YH, Suh H, Jeong LS.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/s0960-894x(01)00006-3

Bibliografisk träff 2000-09-01

Naphthalene carboxamides as inhibitors of human cytomegalovirus DNA polymerase.

Vaillancourt VA, Cudahy MM, Staley SA, Brideau RJ, Conrad SJ, Knechtel ML, Oien NL, Wieber JL, Yagi Y, Wathen MW.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(00)00402-9

Bibliografisk träff 2000-08-01

Benzothiadiazine dioxide dibenzyl derivatives as potent human cytomegalovirus inhibitors: synthesis and comparative molecular field analysis.

Martinez A, Gil C, Abasolo MI, Castro A, Bruno AM, Perez C, Prieto C, Otero J.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm000033p

Bibliografisk träff 2000-08-01

Nonnucleoside human cytomegalovirus inhibitors: synthesis and antiviral evaluation of (chlorophenylmethyl)benzothiadiazine dioxide derivatives.

Martinez A, Gil C, Perez C, Castro A, Prieto C, Otero J, Andrei G, Snoeck R, Balzarini J, De Clercq E.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm000118q

Bibliografisk träff 2000-07-01

Design and evaluation of dihydroisoquinolines as potent and orally bioavailable human cytomegalovirus inhibitors.

Chan L, Stefanac T, Turcotte N, Hu Z, Chen Y, Bédard J, May S, Jin H.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(00)00265-1

Bibliografisk träff 2000-06-01

Design, synthesis, and biological evaluation of tricyclic nucleosides (dimensional probes) as analogues of certain antiviral polyhalogenated benzimidazole ribonucleosides.

Zhu Z, Lippa B, Drach JC, Townsend LB.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm990290y

Bibliografisk träff 2000-06-01

Synthesis and antiviral evaluation of trisubstituted indole N-nucleosides as analogues of 2,5,6-trichloro-1-(beta-D-ribofuranosyl)benzimidazole (TCRB).

Chen JJ, Wei Y, Drach JC, Townsend LB.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm990320x

Bibliografisk träff 2000-06-01

Synthesis and antiviral evaluation of halogenated beta-D- and -L-erythrofuranosylbenzimidazoles.

Gudmundsson KS, Tidwell J, Lippa N, Koszalka GW, van Draanen N, Ptak RG, Drach JC, Townsend LB.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm990195p

Bibliografisk träff 2000-06-01

Synthesis of fluorosugar analogues of 2,5,6-trichloro-1-(beta-D-ribofuranosyl)benzimidazole as antivirals with potentially increased glycosidic bond stability.

Gudmundsson KS, Freeman GA, Drach JC, Townsend LB.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm990219s

Bibliografisk träff 2000-02-01

The cyclohexene ring system as a furanose mimic: synthesis and antiviral activity of both enantiomers of cyclohexenylguanine.

Wang J, Froeyen M, Hendrix C, Andrei G, Snoeck R, De Clercq E, Herdewijn P.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm991171l

Bibliografisk träff 1999-11-01

Chlorophenylmethyl benzothiadiazine dioxides derivatives: potent human cytomegalovirus inhibitors.

Martinez A, Gil C, Perez C, Castro A, Prieto C, Otero J.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/s0960-894x(99)00538-7

Bibliografisk träff 1999-08-01

Discovery of 1,6-naphthyridines as a novel class of potent and selective human cytomegalovirus inhibitors.

Chan L, Jin H, Stefanac T, Lavallée JF, Falardeau G, Wang W, Bédard J, May S, Yuen L.

J Med Chem · journal article · DOI 10.1021/jm9902483

Bibliografisk träff 1999-07-01

Novel pyrimidine and purine derivatives of L-ascorbic acid: synthesis and biological evaluation.

Raić-Malić S, Hergold-Brundić A, Nagl A, Grdisa M, Pavelić K, De Clercq E, Mintas M.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm991017z

Bibliografisk träff 1999-06-01

Structure-activity relationships of L-dioxolane uracil nucleosides as anti-Epstein Barr virus agents.

Lin JS, Kira T, Gullen E, Choi Y, Qu F, Chu CK, Cheng YC.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm9806749

Bibliografisk träff 1999-04-01

Novel potential agents for human cytomegalovirus infection: synthesis and antiviral activity evaluation of benzothiadiazine dioxide acyclonucleosides.

Martinez A, Esteban AI, Castro A, Gil C, Conde S, Andrei G, Snoeck R, Balzarini J, De Clercq E.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm980327z

Bibliografisk träff 1999-01-01

Synthesis and evaluation of 2-amino-9-(1, 3-dihydroxy-2-propoxymethyl)- 6-fluoropurine mono- and diesters as potential prodrugs of ganciclovir.

Kim DK, Chang K, Im GJ, Kim HT, Lee N, Kim KH.

J Med Chem · journal article · DOI 10.1021/jm980321+

Bibliografisk träff 1998-12-01

Antiviral oligo- and polyribonucleotides containing selected triazolo[2,3-a]purines.

Tutonda MG, Buckheit RW, Agrawal VK, Broom AD.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/jm9802057

Bibliografisk träff 1998-12-01

Synthesis of imidazo[1,2-a]pyridines as antiviral agents.

Gueiffier A, Mavel S, Lhassani M, Elhakmaoui A, Snoeck R, Andrei G, Chavignon O, Teulade JC, Witvrouw M, Balzarini J, De Clercq E, Chapat JP.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm981051y

Bibliografisk träff 1998-12-01

Design and synthesis of a novel class of nucleotide analogs with anti-HCMV activity.

Nguyen-Ba P, Lee N, Mitchell H, Chan L, Quimpère M.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(98)00648-9

Bibliografisk träff 1998-12-01

Identification of novel nucleotide phosphonate analogs with potent anti-HCMV activity.

Nguyen-Ba P, Turcotte N, Yuen L, Bédard J, Quimpère M, Chan L.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(98)00649-0

Bibliografisk träff 1998-04-01

Synthesis and antiviral evaluation of certain novel pyrazinoic acid C-nucleosides.

Walker JA, Liu W, Wise DS, Drach JC, Townsend LB.

J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm970532z

Bibliografisk träff 1998-04-01

Design, synthesis, and antiviral activity of alpha-nucleosides: D- and L-isomers of lyxofuranosyl- and (5-deoxylyxofuranosyl)benzimidazoles.

Migawa MT, Girardet JL, Walker JA, Koszalka GW, Chamberlain SD, Drach JC, Townsend LB.

J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm970545c

Bibliografisk träff 1998-04-01

Synthesis and antiviral activity of novel isodideoxy nucleosides with exocyclic methylene.

Jeong LS, Yoo SJ.

Bioorg Med Chem Lett · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1016/s0960-894x(98)00122-x

Bibliografisk träff 1998-01-01

(Z)- and (E)-2-((hydroxymethyl)cyclopropylidene)methyladenine and -guanine. New nucleoside analogues with a broad-spectrum antiviral activity.

Qiu YL, Ksebati MB, Ptak RG, Fan BY, Breitenbach JM, Lin JS, Cheng YC, Kern ER, Drach JC, Zemlicka J.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm9705723

Bibliografisk träff 1997-07-01

A facile, alternative synthesis of 4'-thioarabinonucleosides and their biological activities.

Yoshimura Y, Watanabe M, Satoh H, Ashida N, Ijichi K, Sakata S, Machida H, Matsuda A.

J Med Chem · journal article · DOI 10.1021/jm9701536