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Publications in the selection

138 hits

Bibliografisk träff 1997-02-01

Novel 3'-C/N-substituted 2',3'-beta-D-dideoxynucleosides as potential chemotherapeutic agents. 1. Thymidine derivatives: synthesis, structure, and broad spectrum antiviral properties.

Fedorov II, Kazmina EM, Gurskaya GV, Jasko MV, Zavodnic VE, Balzarini J, De Clercq E, Faraj A, Sommadossi JP, Imbach JL, Gosselin G.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm960500w

Bibliografisk träff 1997-02-01

Synthesis and antiproliferative and antiviral activity of carbohydrate-modified pyrrolo[2,3-d]pyridazin-7-one nucleosides.

Meade EA, Wotring LL, Drach JC, Townsend LB.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm960631x

Bibliografisk träff 1997-02-01

Design, synthesis, and antiviral evaluation of 2-substituted 4,5-dichloro- and 4,6-dichloro-1-beta-D-ribofuranosylbenzimidazoles as potential agents for human cytomegalovirus infections.

Zou R, Drach JC, Townsend LB.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm960533b

Bibliografisk träff 1997-02-01

Design, synthesis, and antiviral evaluation of 2-chloro-5,6-dihalo-1-beta-D-ribofuranosylbenzimidazoles as potential agents for human cytomegalovirus infections.

Zou R, Drach JC, Townsend LB.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm960462g

Bibliografisk träff 1996-11-01

Computation of brain-blood partitioning of organic solutes via free energy calculations.

Lombardo F, Blake JF, Curatolo WJ.

J Med Chem · journal article · DOI 10.1021/jm960163r

Bibliografisk träff 1996-08-01

Synthesis and antiviral activity evaluation of some new aminoadamantane derivatives. 2.

Kolocouris N, Kolocouris A, Foscolos GB, Fytas G, Neyts J, Padalko E, Balzarini J, Snoeck R, Andrei G, De Clercq E.

J Med Chem · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1021/jm950891z

Bibliografisk träff 1996-08-01

Synthesis of non-nucleoside analogs of toyocamycin, sangivamycin, and thiosangivamycin: the effect of certain 4- and 4,6-substituents on the antiviral activity of pyrrolo[2,3-d]pyrimidines.

Renau TE, Kennedy C, Ptak RG, Breitenbach JM, Drach JC, Townsend LB.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm950835y

Bibliografisk träff 1996-08-01

Synthesis and antiviral evaluation of certain disubstituted benzimidazole ribonucleosides.

Zou R, Ayres KR, Drach JC, Townsend LB.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm960157v

Bibliografisk träff 1996-07-01

Synthesis of acyclo-C-nucleosides in the imidazo[1,2-a]pyridine and pyrimidine series as antiviral agents.

Gueiffier A, Lhassani M, Elhakmaoui A, Snoeck R, Andrei G, Chavignon O, Teulade JC, Kerbal A, Essassi EM, Debouzy JC, Witvrouw M, Blache Y, Balzarini J, De Clercq E, Chapat JP.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm9507901

Bibliografisk träff 1996-02-01

Structure-activity relationships among 2-substituted 5,6-dichloro-, 4,6-dichloro-, and 4,5-dichloro-1-[(2-hydroxyethoxy) methyl]- and -1-[(1,3-dihydroxy-2-propoxy) methyl]benzimidazoles.

Saluja S, Zou R, Drach JC, Townsend LB.

J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm950556a

Bibliografisk träff 1995-09-01

Synthesis and anti-DNA viral activities in vitro of certain 2,4-disubstituted-7-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)pyrrolo[2,3-d d pyrimidine nucleosides.

Bhattacharya BK, Ojwang JO, Rando RF, Huffman JH, Revankar GR.

J Med Chem · journal article · DOI 10.1021/jm00020a009

Bibliografisk träff 1995-09-01

Synthesis and antiproliferative and antiviral activity of 2'-deoxy-2'-fluoroarabinofuranosyl analogs of the nucleoside antibiotics toyocamycin and sangivamycin.

Krawczyk SH, Nassiri MR, Kucera LS, Kern ER, Ptak RG, Wotring LL, Drach JC, Townsend LB.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00020a026

Bibliografisk träff 1995-09-01

Synthesis and evaluation of certain thiosangivamycin analogs as potential inhibitors of cell proliferation and human cytomegalovirus.

Krawczyk SH, Renau TE, Nassiri MR, Westerman AC, Wotring LL, Drach JC, Townsend LB.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00020a027

Bibliografisk träff 1995-05-01

Haloanilino derivatives of pyrimidines, purines, and purine nucleoside analogs: synthesis and activity against human cytomegalovirus.

Medveczky M, Yang TF, Gambino J, Medveczky P, Wright GE.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00010a026

Bibliografisk träff 1995-03-01

Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides.

Verheggen I, Van Aerschot A, Van Meervelt L, Rozenski J, Wiebe L, Snoeck R, Andrei G, Balzarini J, Claes P, De Clercq E.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00005a010

Bibliografisk träff 1994-09-01

Tricyclic analogues of acyclovir and ganciclovir. Influence of substituents in the heterocyclic moiety on the antiviral activity.

Golankiewicz B, Ostrowski T, Andrei G, Snoeck R, De Clercq E.

J Med Chem · journal article · DOI 10.1021/jm00045a025

Bibliografisk träff 1994-09-01

Benzimidazole ribonucleosides: design, synthesis, and antiviral activity of certain 2-(alkylthio)- and 2-(benzylthio)-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazoles.

Devivar RV, Kawashima E, Revankar GR, Breitenbach JM, Kreske ED, Drach JC, Townsend LB.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00044a015

Bibliografisk träff 1994-04-01

An enantiospecific synthesis of the human cytomegalovirus antiviral agent [(R)-3-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-4- hydroxybutyl]phosphonic acid.

Chamberlain SD, Biron KK, Dornsife RE, Averett DR, Beauchamp L, Koszalka GW.

J Med Chem · comparative study; journal article · DOI 10.1021/jm00035a018

Bibliografisk träff 1993-11-01

Synthesis, antiproliferative, and antiviral activity of 4-amino-1-(beta-D-ribofuranosyl)pyrrolo[2,3-d]pyridazin-7(6H)-one and related derivatives.

Meade EA, Wotring LL, Drach JC, Townsend LB.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00076a011

Bibliografisk träff 1993-08-01

Synthesis and antiviral activity of novel 5-(1-azido-2-haloethyl) and 5-(1-azido-, amino-, or methoxyethyl) analogs of 2'-deoxyuridine.

Kumar R, Wiebe LI, Knaus EE.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00069a004

Bibliografisk träff 1992-08-01

Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine.

Yu KL, Bronson JJ, Yang H, Patick A, Alam M, Brankovan V, Datema R, Hitchcock MJ, Martin JC.

J Med Chem · journal article · DOI 10.1021/jm00094a005

Bibliografisk träff 1992-06-01

(+-)-carbocyclic 5'-nor-2'-deoxyguanosine and related purine derivatives: synthesis and antiviral properties.

Patil SD, Koga M, Schneller SW, Snoeck R, De Clercq E.

J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00090a007

Bibliografisk träff 1992-02-01

Synthesis, antiproliferative, and antiviral activity of certain 4-aminopyrrolo[2,3-d]pyridazine nucleosides: an entry into a novel series of adenosine analogues.

Meade EA, Wotring LL, Drach JC, Townsend LB.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00081a014

Bibliografisk träff 1991-08-01

Synthesis and antiviral activity of 3-substituted derivatives of 3,9-dihydro-9-oxo-5H-imidazo[1,2-a]purines, tricyclic analogues of acyclovir and ganciclovir.

Boryski J, Golankiewicz B, De Clercq E.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00112a010

Bibliografisk träff 1991-04-01

Synthesis and antiviral activity of enantiomeric forms of cyclobutyl nucleoside analogues.

Bisacchi GS, Braitman A, Cianci CW, Clark JM, Field AK, Hagen ME, Hockstein DR, Malley MF, Mitt T, Slusarchyk WA.

J Med Chem · comparative study; journal article · DOI 10.1021/jm00108a026

Bibliografisk träff 1990-12-01

Arabinofuranosylpyrrolo[2,3-d]pyrimidines as potential agents for human cytomegalovirus infections.

Krawczyk SH, Bernier-Rodriguez M, Nassiri MR, Kern ER, Wotring LL, Drach JC, Townsend LB.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00174a011

Bibliografisk träff 1990-09-01

Synthesis of new (+-)-3,5-dihydroxypentyl nucleoside analogues from 1-amino-5-(benzyloxy)pentan-3-ol and their antiviral evaluation.

Legraverend M, Boumchita H, Zerial A, Huel C, Lemaitre M, Bisagni E.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00171a022

Bibliografisk träff 1990-08-01

Synthesis and antiviral activity of some acyclic and C-acyclic pyrrolo[2,3-d]pyrimidine nucleoside analogues.

Bennett SM, Nguyen-Ba N, Ogilvie KK.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00170a019

Bibliografisk träff 1990-07-01

Synthesis and antiviral activity of some 7-[(2-hydroxyethoxy)methyl]pyrazolo[3,4-d]pyrimidine analogues of sangivamycin and toyocamycin.

Saxena NK, Coleman LA, Drach JC, Townsend LB.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00169a027

Bibliografisk träff 1990-07-01

Synthesis, antiproliferative, and antiviral activity of certain 4-substituted and 4,5-disubstituted 7-[(1,3-dihydroxy-2-propoxy)methyl]pyrrolo[2,3-d]pyrimidines.

Pudlo JS, Nassiri MR, Kern ER, Wotring LL, Drach JC, Townsend LB.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00169a028