The toll-like receptor 2 agonist Pam3CSK4 is neuroprotective after spinal cord injury.
Stivers NS, Pelisch N, Orem BC, Williams J, Nally JM, Stirling DP.
Exp Neurol · journal article · DOI 10.1016/j.expneurol.2017.04.012 PUBLICATION REGISTRY
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29 hitsHypothermic Neuronal Rescue from Infection-Sensitised Hypoxic-Ischaemic Brain Injury Is Pathogen Dependent.
Falck M, Osredkar D, Maes E, Flatebø T, Wood TR, Sabir H, Thoresen M.
Dev Neurosci · research support, non-u.s. gov't; journal article · DOI 10.1159/000455838Pam3CSK4 Induces MMP-9 Expression in Human Monocytic THP-1 Cells.
Al-Rashed F, Kochumon S, Usmani S, Sindhu S, Ahmad R.
Cell Physiol Biochem · journal article · DOI 10.1159/000475298Detection of the Lipopeptide Pam3CSK4 Using a Hybridized Toll-like Receptor Electrochemical Sensor.
She Z, Topping K, Ma T, Zhao T, Zhou W, Kamal A, Ahmadi S, Kraatz HB.
Anal Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.analchem.6b04799The inflammatory cytokine effect of Pam3CSK4 TLR2 agonist alone or in combination with Leishmania infantum antigen on ex-vivo whole blood from sick and resistant dogs.
Martínez-Orellana P, Quirola-Amores P, Montserrat-Sangrà S, Ordeix L, Llull J, Álvarez-Fernández A, Solano-Gallego L.
Parasit Vectors · research-article; journal article · DOI 10.1186/s13071-017-2062-3Over-expression of Toll-like receptor 2 up-regulates heme oxygenase-1 expression and decreases oxidative injury in dairy goats.
Deng S, Yu K, Jiang W, Li Y, Wang S, Deng Z, Yao Y, Zhang B, Liu G, Liu Y, Lian Z.
J Anim Sci Biotechnol · research-article; journal article · DOI 10.1186/s40104-016-0136-2Toll-Like Receptor 2 Agonist Pam3CSK4 Alleviates the Pathology of Leptospirosis in Hamster.
Zhang W, Zhang N, Xie X, Guo J, Jin X, Xue F, Ding Z, Cao Y.
Infect Immun · research-article; journal article · DOI 10.1128/iai.00708-16C4b binding protein negatively regulates TLR1/2 response.
Morita N, Yamai I, Takahashi K, Kusumoto Y, Shibata T, Kobayashi T, Nonaka MI, Ichimonji I, Takagi H, Miyake K, Takamura SA.
Innate Immun · research support, non-u.s. gov't; journal article · DOI 10.1177/1753425916672312NOD2 up-regulates TLR2-mediated IL-23p19 expression via NF-κB subunit c-Rel in Paneth cell-like cells.
Tan G, Liang E, Liao K, Deng F, Zhang W, Chen Y, Xu J, Zhi F.
Oncotarget · research-article; journal article · DOI 10.18632/oncotarget.11467Control of Methicillin-Resistant Staphylococcus aureus Pneumonia Utilizing TLR2 Agonist Pam3CSK4.
Chen YG, Zhang Y, Deng LQ, Chen H, Zhang YJ, Zhou NJ, Yuan K, Yu LZ, Xiong ZH, Gui XM, Yu YR, Wu XM, Min WP.
PLoS One · research-article; journal article · DOI 10.1371/journal.pone.0149233[Protective effect of pretreatment with TLR2 agonist Pam3Csk4 on mice challenged by methicillin-resistant Staphylococcus aureus].
Chen Y, Chen H, Deng L, Gui X, Yu L, Xiong Z, Min W, Wu X.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi · journal article; english abstractEchinacea purpurea root extract inhibits TNF release in response to Pam3Csk4 in a phosphatidylinositol-3-kinase dependent manner.
Fast DJ, Balles JA, Scholten JD, Mulder T, Rana J.
Cell Immunol · journal article · DOI 10.1016/j.cellimm.2015.07.003Effect of the synthetic Toll-like receptor ligands LPS, Pam3CSK4, HKLM and FSL-1 in the function of bovine polymorphonuclear neutrophils.
Conejeros I, Gibson AJ, Werling D, Muñoz-Caro T, Hermosilla C, Taubert A, Burgos RA.
Dev Comp Immunol · research support, non-u.s. gov't; journal article · DOI 10.1016/j.dci.2015.05.012Toll-like receptor 2 agonist Pam3CSK4 up-regulates FcεRI receptor expression on monocytes from patients with severe extrinsic atopic dermatitis.
Song Z, Deng X, Chen W, Xu J, Chen S, Zhong H, Hao F.
J Eur Acad Dermatol Venereol · research support, non-u.s. gov't; journal article · DOI 10.1111/jdv.13172Coinjection with TLR2 agonist Pam3CSK4 reduces the pathology of leishmanization in mice.
Huang L, Hinchman M, Mendez S.
PLoS Negl Trop Dis · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1371/journal.pntd.0003546Differential effects of the Toll-like receptor 2 agonists, PGN and Pam3CSK4 on anti-IgE induced human mast cell activation.
Yu Y, Yip KH, Tam IY, Sam SW, Ng CW, Zhang W, Lau HY.
PLoS One · research support, non-u.s. gov't; research-article; journal article · DOI 10.1371/journal.pone.0112989Cutting edge: Genetic variation in TLR1 is associated with Pam3CSK4-induced effector T cell resistance to regulatory T cell suppression.
Mikacenic C, Schneider A, Radella F, Buckner JH, Wurfel MM.
J Immunol · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.4049/jimmunol.1401185Synergistic anticancer effects of Pam3CSK4 and Ara-C on B-cell lymphoma cells.
Lee SK, Chwee JY, Ma CA, Le Bert N, Huang CW, Gasser S.
Clin Cancer Res · research support, non-u.s. gov't; journal article · DOI 10.1158/1078-0432.ccr-13-2522A20 is critical for the induction of Pam3CSK4-tolerance in monocytic THP-1 cells.
Hu J, Wang G, Liu X, Zhou L, Jiang M, Yang L.
PLoS One · research support, non-u.s. gov't; research-article; journal article · DOI 10.1371/journal.pone.0087528Different effects of Porphyromonas gingivalis lipopolysaccharide and TLR2 agonist Pam3CSK4 on the adhesion molecules expression in endothelial cells.
Andrukhov O, Steiner I, Liu S, Bantleon HP, Moritz A, Rausch-Fan X.
Odontology · research support, non-u.s. gov't; journal article · DOI 10.1007/s10266-013-0146-xA Toll-like receptor 2 ligand, Pam3CSK4, augments interferon-γ-induced nitric oxide production via a physical association between MyD88 and interferon-γ receptor in vascular endothelial cells.
Tsolmongyn B, Koide N, Jambalganiin U, Odkhuu E, Naiki Y, Komatsu T, Yoshida T, Yokochi T.
Immunology · research support, non-u.s. gov't; journal article · DOI 10.1111/imm.12147The TLR2 agonists lipoteichoic acid and Pam3CSK4 induce greater pro-inflammatory responses than inactivated Mycobacterium butyricum.
Gambhir V, Yildiz C, Mulder R, Siddiqui S, Guzzo C, Szewczuk M, Gee K, Basta S.
Cell Immunol · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1016/j.cellimm.2012.12.001Pam3CSK4/TLR2 signaling elicits neutrophil recruitment and restricts invasion of Escherichia coli P4 into mammary gland epithelial cells in a murine mastitis model.
Mintz M, Mintz D, Ezra-Elia R, Shpigel NY.
Vet Immunol Immunopathol · research support, non-u.s. gov't; journal article · DOI 10.1016/j.vetimm.2012.09.030MF59 and Pam3CSK4 boost adaptive responses to influenza subunit vaccine through an IFN type I-independent mechanism of action.
Caproni E, Tritto E, Cortese M, Muzzi A, Mosca F, Monaci E, Baudner B, Seubert A, De Gregorio E.
J Immunol · journal article · DOI 10.4049/jimmunol.1101764The synthetic bacterial lipopeptide Pam3CSK4 modulates respiratory syncytial virus infection independent of TLR activation.
Nguyen DT, de Witte L, Ludlow M, Yüksel S, Wiesmüller KH, Geijtenbeek TB, Osterhaus AD, de Swart RL.
PLoS Pathog · research support, non-u.s. gov't; research-article; journal article · DOI 10.1371/journal.ppat.1001049Preconditioning by toll-like receptor 2 agonist Pam3CSK4 reduces CXCL1-dependent leukocyte recruitment in murine myocardial ischemia/reperfusion injury.
Mersmann J, Berkels R, Zacharowski P, Tran N, Koch A, Iekushi K, Dimmeler S, Granja TF, Boehm O, Claycomb WC, Zacharowski K.
Crit Care Med · research support, non-u.s. gov't; journal article · DOI 10.1097/ccm.0b013e3181ce50e6Genome-wide transcriptional profiling of mononuclear phagocytes recruited to mouse lungs in response to alveolar challenge with the TLR2 agonist Pam3CSK4.
Cabanski M, Wilhelm J, Zaslona Z, Steinmüller M, Fink L, Seeger W, Lohmeyer J.
Am J Physiol Lung Cell Mol Physiol · research support, non-u.s. gov't; journal article · DOI 10.1152/ajplung.90433.2008Toll-like receptor 2 agonist Pam3CSK4 enhances the induction of antigen-specific tolerance via the sublingual route.
Lombardi V, Van Overtvelt L, Horiot S, Moussu H, Chabre H, Louise A, Balazuc AM, Mascarell L, Moingeon P.
Clin Exp Allergy · journal article · DOI 10.1111/j.1365-2222.2008.03056.xPam3CSK4 and LTA-TLRs ligands associated with microdomains induce IL8 production in human adrenocortical cancer cells.
Kanczkowski W, Morawietz H, Ziegler CG, Funk RH, Schmitz G, Zacharowski K, Mohn CE, Ehrhart-Bornstein M, Bornstein SR.
Horm Metab Res · research support, non-u.s. gov't; journal article · DOI 10.1055/s-2007-980189