Novel antiarrhythmic drugs in atrial fibrillation: focus on tedisamil.
Krishnamoorthy S, Lip GY.
Expert Opin Investig Drugs · review; journal article · DOI 10.1517/13543780903114150 PUBLICATION REGISTRY
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21 hitsClinically important interaction between tedisamil and verapamil.
van Haarst AD, Dijkmans AC, Weimann HJ, Kemme MJ, Bosch JJ, Schoemaker RC, Cohen AF, Burggraaf J.
J Clin Pharmacol · clinical trial; research support, non-u.s. gov't; journal article · DOI 10.1177/0091270009332812The transmembrane beta-subunits KCNE1, KCNE2, and DPP6 modify pharmacological effects of the antiarrhythmic agent tedisamil on the transient outward current Ito.
Radicke S, Cotella D, Sblattero D, Ravens U, Santoro C, Wettwer E.
Naunyn Schmiedebergs Arch Pharmacol · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1007/s00210-008-0389-1Effect of the antifibrillatory compound tedisamil (KC-8857) on transmembrane currents in mammalian ventricular myocytes.
Jost N, Virág L, Hála O, Varró A, Thormählen D, Papp JG.
Curr Med Chem · comparative study; research support, non-u.s. gov't; journal article · DOI 10.2174/0929867043363631Tedisamil attenuates foetal transformation of myosin in the hypertrophied rat myocardium.
Turcani M, Thormaehlen D, Rupp H.
Br J Pharmacol · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/sj.bjp.0705992Tedisamil: a new novel antiarrhythmic.
Freestone B, Lip GY.
Expert Opin Investig Drugs · evaluation study; journal article · DOI 10.1517/13543784.13.2.151Tedisamil: master switch of nature?
Doggrell SA.
Expert Opin Investig Drugs · research support, non-u.s. gov't; review; journal article · DOI 10.1517/13543784.10.1.129Tedisamil (Solvay).
Flores NA.
Curr Opin Investig Drugs · journal articleThe role of sarcoplasmic reticulum in the protective effect of class III drugs against Ca2+ overload.
Manoach M, Varon D, Tribulova N, Zinman T, Kaplan D, Khananshvili D, Shainberg A.
Gen Physiol Biophys · journal articleTedisamil. KC 8857.
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Drugs R D · journal article · DOI 10.2165/00126839-199901040-00010Mechanism of block by tedisamil of transient outward current in human ventricular subepicardial myocytes.
Wettwer E, Himmel HM, Amos GJ, Li Q, Metzger F, Ravens U.
Br J Pharmacol · research-article; journal article · DOI 10.1038/sj.bjp.0702110Synthesis, pharmacological characterization, and quantitative structure-activity relationship analyses of 3,7,9,9-tetraalkylbispidines: derivatives with specific bradycardic activity.
Schön U, Antel J, Brückner R, Messinger J, Franke R, Gruska A.
J Med Chem · journal article · DOI 10.1021/jm970120qEffects of tedisamil (KC-8857) on cardiac electrophysiology and ventricular fibrillation in the rabbit isolated heart.
Chi L, Park JL, Friedrichs GS, Banglawala YA, Perez MA, Tanhehco EJ, Lucchesi BR.
Br J Pharmacol · comparative study; research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; research-article; journal article · DOI 10.1111/j.1476-5381.1996.tb16724.xThe cellular electrophysiological effects of tedisamil in human atrial and ventricular fibers.
Németh M, Virág L, Hála O, Varró A, Kovács G, Thormählen D, Papp JG.
Cardiovasc Res · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1016/s0008-6363(95)00189-1Tedisamil (KC 8857) is a new specific bradycardic drug: does it also influence myocardial contractility? Analysis by the conductance (volume) technique in coronary artery disease.
Thormann J, Mitrovic V, Riedel H, Neuzner J, Strasser R, Bahavar H, Schlepper M.
Am Heart J · clinical trial; journal article · DOI 10.1016/0002-8703(93)90990-qDifferential inhibition by tedisamil (KC 8857) and glibenclamide of the responses to cromakalim and minoxidil sulphate in rat isolated aorta.
Bray K, Quast U.
Naunyn Schmiedebergs Arch Pharmacol · journal article · DOI 10.1007/bf00165744Tedisamil (KC 8857) differentially inhibits the 86Rb+ efflux-stimulating and vasorelaxant properties of cromakalim.
Bray K, Quast U.
Eur J Pharmacol · comparative study; journal article · DOI 10.1016/0014-2999(91)90680-oActions of cardiac drugs on a calcium-dependent potassium channel in hippocampal neurons.
McLarnon JG, Wang XP.
Mol Pharmacol · research support, non-u.s. gov't; journal article · DOI 10.1016/s0026-895x(25)11019-5Antiarrhythmic properties of tedisamil (KC8857), a putative transient outward K+ current blocker.
Beatch GN, Abraham S, MacLeod BA, Yoshida NR, Walker MJ.
Br J Pharmacol · research support, non-u.s. gov't; research-article; journal article · DOI 10.1111/j.1476-5381.1991.tb12124.xCardiac and hemodynamic effects of the selective bradycardic agent KC 8857 during exercise-induced myocardial ischemia.
Grohs JG, Fischer G, Raberger G.
Eur J Pharmacol · research support, non-u.s. gov't; journal article · DOI 10.1016/0014-2999(89)90179-9Further studies into the ECG effects of tedisamil (KC 8857) in rats.
Howard PG, Abraham S, Courtice ID, Walker MJ.
Proc West Pharmacol Soc · research support, non-u.s. gov't; journal article