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24 hits

Bibliografisk träff 2023-07-19

A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs.

Sutherland JJ, Yonchev D, Fekete A, Urban L.

Nat Commun · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/s41467-023-40064-9

Bibliografisk träff 2023-03-28

Anagrelide: A Clinically Effective cAMP Phosphodiesterase 3A Inhibitor with Molecular Glue Properties.

Meanwell NA.

ACS Med Chem Lett · article-commentary; journal article · DOI 10.1021/acsmedchemlett.3c00092

Bibliografisk träff 2013-08-16

A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.

Morgan RE, van Staden CJ, Chen Y, Kalyanaraman N, Kalanzi J, Dunn RT, Afshari CA, Hamadeh HK.

Toxicol Sci · journal article · DOI 10.1093/toxsci/kft176

Bibliografisk träff 2010-01-01

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Fourches D, Barnes JC, Day NC, Bradley P, Reed JZ, Tropsha A.

Chem Res Toxicol · research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/tx900326k

Bibliografisk träff 2009-08-01

Physicochemical determinants of human renal clearance.

Varma MV, Feng B, Obach RS, Troutman MD, Chupka J, Miller HR, El-Kattan A.

J Med Chem · journal article · DOI 10.1021/jm900403j

Bibliografisk träff 2008-04-21

Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.

Obach RS, Lombardo F, Waters NJ.

Drug Metab Dispos · journal article · DOI 10.1124/dmd.108.020479

Bibliografisk träff 2007-09-01

Hologram QSAR model for the prediction of human oral bioavailability.

Moda TL, Montanari CA, Andricopulo AD.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2007.08.060

Bibliografisk träff 2007-04-08

Chemical genetics reveals a complex functional ground state of neural stem cells.

Diamandis P, Wildenhain J, Clarke ID, Sacher AG, Graham J, Bellows DS, Ling EK, Ward RJ, Jamieson LG, Tyers M, Dirks PB.

Nat Chem Biol · research support, non-u.s. gov't; journal article · DOI 10.1038/nchembio873

Bibliografisk träff 2004-08-01

[Drug-induced liver injury; fourteenth updated edition of the bibliographic database of liver injuries and related drugs].

Biour M, Ben Salem C, Chazouillères O, Grangé JD, Serfaty L, Poupon R.

Gastroenterol Clin Biol · bibliography; journal article · DOI 10.1016/s0399-8320(04)95062-2

Bibliografisk träff 2000-06-01

QSAR model for drug human oral bioavailability.

Yoshida F, Topliss JG.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm0000564

Bibliografisk träff 1990-01-01

Synthesis and cardiotonic activity of novel biimidazoles.

Matthews DP, McCarthy JR, Whitten JP, Kastner PR, Barney CL, Marshall FN, Ertel MA, Burkhard T, Shea PJ, Kariya T.

J Med Chem · comparative study; journal article · DOI 10.1021/jm00163a052

Bibliografisk träff 1989-02-01

Cardiotonic agents. 9. Synthesis and biological evaluation of a series of (E)-4,5-dihydro-6-[2-[4-(1H-imidazol-1-yl)phenyl]ethenyl]-3 (2H)-pyridazinones: a novel class of compounds with positive inotropic, antithrombotic, and vasodilatory activities for the treatment of congestive heart failure.

Sircar I, Steffen RP, Bobowski G, Burke SE, Newton RS, Weishaar RE, Bristol JA, Evans DB.

J Med Chem · journal article · DOI 10.1021/jm00122a011

Bibliografisk träff 1988-10-01

2(1H)-quinolinones with cardiac stimulant activity. 1. Synthesis and biological activities of (six-membered heteroaryl)-substituted derivatives.

Alabaster CT, Bell AS, Campbell SF, Ellis P, Henderson CG, Roberts DA, Ruddock KS, Samuels GM, Stefaniak MH.

J Med Chem · journal article · DOI 10.1021/jm00118a034

Bibliografisk träff 1988-04-01

Chemistry and positive inotropic effect of pelrinone and related derivatives. A novel class of 2-methylpyrimidones as inotropic agents.

Bagli J, Bogri T, Palameta B, Rakhit S, Peseckis S, McQuillan J, Lee DK.

J Med Chem · journal article · DOI 10.1021/jm00399a023

Bibliografisk träff 1987-11-01

Cardiotonic agents. 8. Selective inhibitors of adenosine 3',5'-cyclic phosphate phosphodiesterase III. Elaboration of a five-point model for positive inotropic activity.

Moos WH, Humblet CC, Sircar I, Rithner C, Weishaar RE, Bristol JA, McPhail AT.

J Med Chem · journal article · DOI 10.1021/jm00394a006

Bibliografisk träff 1987-08-01

Cardiotonic agents. 1. Novel 8-aryl-substituted imidazo[1,2-a]- and -[1,5-a]pyridines and imidazo[1,5-a]pyridinones as potential positive inotropic agents.

Davey D, Erhardt PW, Lumma WC, Wiggins J, Sullivan M, Pang D, Cantor E.

J Med Chem · comparative study; journal article · DOI 10.1021/jm00391a012

Bibliografisk träff 1987-08-01

Cardiotonic agents. 2. (Imidazolyl)aroylimidazolones, highly potent and selective positive inotropic agents.

Hagedorn AA, Erhardt PW, Lumma WC, Wohl RA, Cantor E, Chou YL, Ingebretsen WR, Lampe JW, Pang D, Pease CA.

J Med Chem · comparative study; journal article · DOI 10.1021/jm00391a013

Bibliografisk träff 1987-05-01

Dihydropyridazinone cardiotonics: synthesis and inotropic activity of 5'-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)spiro[cycloalkane- 1,3'-[3H]indol]-2'(1'H)-ones.

Robertson DW, Krushinski JH, Pollock GD, Wilson H, Kauffman RF, Hayes JS.

J Med Chem · comparative study; journal article · DOI 10.1021/jm00388a014

Bibliografisk träff 1987-02-01

In search of the digitalis replacement.

Erhardt PW.

J Med Chem · review; journal article · DOI 10.1021/jm00385a001

Bibliografisk träff 1987-02-01

Inhibitors of cyclic AMP phosphodiesterase. 2. Structural variations of N-cyclohexyl-N-methyl-4-[(1,2,3,5-tetrahydro- 2-oxoimidazo[2,1-b]quinazolin-7-yl)-oxy]butyramide (RS-82856).

Venuti MC, Jones GH, Alvarez R, Bruno JJ.

J Med Chem · comparative study; journal article · DOI 10.1021/jm00385a012

Bibliografisk träff 1985-10-01

Cardiotonic agents. 2. Synthesis and structure-activity relationships of 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones: a new class of positive inotropic agents.

Sircar I, Duell BL, Bobowski G, Bristol JA, Evans DB.

J Med Chem · journal article · DOI 10.1021/jm00148a006

Bibliografisk träff 1985-05-01

A new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivity.

Weishaar RE, Cain MH, Bristol JA.

J Med Chem · review; journal article · DOI 10.1021/jm50001a001

Bibliografisk träff 1984-09-01

Cardiotonic agents. 1. 4,5-Dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3 (2H)-pyridazinones: novel positive inotropic agents for the treatment of congestive heart failure.

Bristol JA, Sircar I, Moos WH, Evans DB, Weishaar RE.

J Med Chem · journal article · DOI 10.1021/jm00375a001

Bibliografisk träff 1982-12-01

4-Aroyl-1,3-dihydro-2H-imidazol-2-ones, a new class of cardiotonic agents.

Schnettler RA, Dage RC, Grisar JM.

J Med Chem · journal article · DOI 10.1021/jm00354a017