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Publikationer som ChEBI hänvisar till för sitaxentan. Visa hela publikationsregistret

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Publications in the selection

11 hits

Bibliografisk träff 2023-07-19

A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs.

Sutherland JJ, Yonchev D, Fekete A, Urban L.

Nat Commun · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/s41467-023-40064-9

Bibliografisk träff 2016-06-10

From bosentan (Tracleer®) to macitentan (Opsumit®): The medicinal chemistry perspective.

Boss C, Bolli MH, Gatfield J.

Bioorg Med Chem Lett · review; journal article · DOI 10.1016/j.bmcl.2016.06.014

Bibliografisk träff 2016-03-03

DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.

Chen M, Suzuki A, Thakkar S, Yu K, Hu C, Tong W.

Drug Discov Today · review; journal article · DOI 10.1016/j.drudis.2016.02.015

Bibliografisk träff 2013-08-16

A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.

Morgan RE, van Staden CJ, Chen Y, Kalyanaraman N, Kalanzi J, Dunn RT, Afshari CA, Hamadeh HK.

Toxicol Sci · journal article · DOI 10.1093/toxsci/kft176

Bibliografisk träff 2010-01-01

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Fourches D, Barnes JC, Day NC, Bradley P, Reed JZ, Tropsha A.

Chem Res Toxicol · research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/tx900326k

Bibliografisk träff 2004-08-01

[Drug-induced liver injury; fourteenth updated edition of the bibliographic database of liver injuries and related drugs].

Biour M, Ben Salem C, Chazouillères O, Grangé JD, Serfaty L, Poupon R.

Gastroenterol Clin Biol · bibliography; journal article · DOI 10.1016/s0399-8320(04)95062-2

Bibliografisk träff 2004-04-01

Discovery, modeling, and human pharmacokinetics of N-(2-acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl)thiophene-2-carboxamide (TBC3711), a second generation, ETA selective, and orally bioavailable endothelin antagonist.

Wu C, Decker ER, Blok N, Bui H, You TJ, Wang J, Bourgoyne AR, Knowles V, Berens KL, Holland GW, Brock TA, Dixon RA.

J Med Chem · clinical trial; clinical trial, phase i; randomized controlled trial; journal article · DOI 10.1021/jm030528p

Bibliografisk träff 2001-04-01

Acyl substitution at the ortho position of anilides enhances oral bioavailability of thiophene sulfonamides: TBC3214, an ETA selective endothelin antagonist.

Wu C, Decker ER, Blok N, Li J, Bourgoyne AR, Bui H, Keller KM, Knowles V, Li W, Stavros FD, Holland GW, Brock TA, Dixon RA.

J Med Chem · journal article · DOI 10.1021/jm000349x

Bibliografisk träff 1999-11-01

Endothelin antagonists: substituted mesitylcarboxamides with high potency and selectivity for ET(A) receptors.

Wu C, Decker ER, Blok N, Bui H, Chen Q, Raju B, Bourgoyne AR, Knowles V, Biediger RJ, Market RV, Lin S, Dupré B, Kogan TP, Holland GW, Brock TA, Dixon RA.

J Med Chem · journal article · DOI 10.1021/jm9900063

Bibliografisk träff 1999-02-01

Pharmacology of A-216546: a highly selective antagonist for endothelin ET(A) receptor.

Wu-Wong JR, Dixon DB, Chiou WJ, Dayton BD, Novosad EI, Adler AL, Wessale JL, Calzadilla SV, Hernandez L, Marsh KC, Liu G, Szczepankiewicz B, von Geldern TW, Opgenorth TJ.

Eur J Pharmacol · journal article · DOI 10.1016/s0014-2999(98)00891-7

Bibliografisk träff 1997-05-01

Discovery of TBC11251, a potent, long acting, orally active endothelin receptor-A selective antagonist.

Wu C, Chan MF, Stavros F, Raju B, Okun I, Mong S, Keller KM, Brock T, Kogan TP, Dixon RA.

J Med Chem · journal article · DOI 10.1021/jm9700068