Plasmodium falciparum topoisomerases: Emerging targets for anti-malarial therapy.
Dar A, Godara P, Prusty D, Bashir M.
Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2023.116056 PUBLICATION REGISTRY
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28 hitsA preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs.
Sutherland JJ, Yonchev D, Fekete A, Urban L.
Nat Commun · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/s41467-023-40064-9Multiple approaches to repurposing drugs for neuroblastoma.
Rank L, Puhl AC, Havener TM, Anderson E, Foil DH, Zorn KM, Monakhova N, Riabova O, Hickey AJ, Makarov V, Ekins S.
Bioorg Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2022.117043Discovery and development of 2-aminobenzimidazoles as potent antimalarials.
Devine SM, Challis MP, Kigotho JK, Siddiqui G, De Paoli A, MacRaild CA, Avery VM, Creek DJ, Norton RS, Scammells PJ.
Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2021.113518Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in <i>Plasmodium falciparum</i>.
Lawong A, Gahalawat S, Okombo J, Striepen J, Yeo T, Mok S, Deni I, Bridgford JL, Niederstrasser H, Zhou A, Posner B, Wittlin S, Gamo FJ, Crespo B, Churchyard A, Baum J, Mittal N, Winzeler E, Laleu B, Palmer MJ, Charman SA, Fidock DA, Ready JM, Phillips MA.
J Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.0c02022Structure activity refinement of phenylsulfonyl piperazines as antimalarials that block erythrocytic invasion.
Nguyen W, Dans MG, Ngo A, Gancheva MR, Romeo O, Duffy S, de Koning-Ward TF, Lowes KN, Sabroux HJ, Avery VM, Wilson DW, Gilson PR, Sleebs BE.
Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2021.113253Toward the Target: Tilorone, Quinacrine, and Pyronaridine Bind to Ebola Virus Glycoprotein.
Lane TR, Ekins S.
ACS Med Chem Lett · brief-report; journal article · DOI 10.1021/acsmedchemlett.0c00298Repurposed drug candidates for antituberculosis therapy.
An Q, Li C, Chen Y, Deng Y, Yang T, Luo Y.
Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2020.112175A Meroisoprenoid, Heptenolides, and <i>C</i>-Benzylated Flavonoids from <i>Sphaerocoryne gracilis</i> ssp. <i>gracilis</i>.
Maeda G, Munissi JJE, Lindblad S, Duffy S, Pelletier J, Avery VM, Nyandoro SS, Erdélyi M.
J Nat Prod · research support, non-u.s. gov't; review-article; journal article · DOI 10.1021/acs.jnatprod.9b00721Acrotrione: An Oxidized Xanthene from the Roots of Acronychia pubescens.
Robertson LP, Lucantoni L, Duffy S, Avery VM, Carroll AR.
J Nat Prod · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jnatprod.8b00956Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases.
Vinh NB, Drinkwater N, Malcolm TR, Kassiou M, Lucantoni L, Grin PM, Butler GS, Duffy S, Overall CM, Avery VM, Scammells PJ, McGowan S.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.8b01310One-pot, multi-component synthesis and structure-activity relationships of peptoid-based histone deacetylase (HDAC) inhibitors targeting malaria parasites.
Diedrich D, Stenzel K, Hesping E, Antonova-Koch Y, Gebru T, Duffy S, Fisher G, Schöler A, Meister S, Kurz T, Avery VM, Winzeler EA, Held J, Andrews KT, Hansen FK.
Eur J Med Chem · research-article; journal article · DOI 10.1016/j.ejmech.2018.09.018Antiplasmodial β-Triketone-Flavanone Hybrids from the Flowers of the Australian Tree Corymbia torelliana.
Senadeera SPD, Lucantoni L, Duffy S, Avery VM, Carroll AR.
J Nat Prod · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jnatprod.8b00154Pimentelamines A-C, Indole Alkaloids Isolated from the Leaves of the Australian Tree Flindersia pimenteliana.
Robertson LP, Duffy S, Wang Y, Wang D, Avery VM, Carroll AR.
J Nat Prod · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jnatprod.7b00587Antiplasmodial β-triketones from the flowers of the Australian tree Angophora woodsiana.
Senadeera SPD, Duffy S, Avery VM, Carroll AR.
Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2017.03.065Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity.
Gilson PR, Tan C, Jarman KE, Lowes KN, Curtis JM, Nguyen W, Di Rago AE, Bullen HE, Prinz B, Duffy S, Baell JB, Hutton CA, Jousset Subroux H, Crabb BS, Avery VM, Cowman AF, Sleebs BE.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.6b01673Polyoxygenated Cyclohexenes and Other Constituents of Cleistochlamys kirkii Leaves.
Nyandoro SS, Munissi JJ, Gruhonjic A, Duffy S, Pan F, Puttreddy R, Holleran JP, Fitzpatrick PA, Pelletier J, Avery VM, Rissanen K, Erdélyi M.
J Nat Prod · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jnatprod.6b00759Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy.
Baragaña B, Norcross NR, Wilson C, Porzelle A, Hallyburton I, Grimaldi R, Osuna-Cabello M, Norval S, Riley J, Stojanovski L, Simeons FR, Wyatt PG, Delves MJ, Meister S, Duffy S, Avery VM, Winzeler EA, Sinden RE, Wittlin S, Frearson JA, Gray DW, Fairlamb AH, Waterson D, Campbell SF, Willis P, Read KD, Gilbert IH.
J Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/acs.jmedchem.6b00723Rotenoids, Flavonoids, and Chalcones from the Root Bark of Millettia usaramensis.
Deyou T, Gumula I, Pang F, Gruhonjic A, Mumo M, Holleran J, Duffy S, Fitzpatrick PA, Heydenreich M, Landberg G, Derese S, Avery V, Rissanen K, Erdélyi M, Yenesew A.
J Nat Prod · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jnatprod.5b00581Discovery of HDAC inhibitors with potent activity against multiple malaria parasite life cycle stages.
Hansen FK, Sumanadasa SD, Stenzel K, Duffy S, Meister S, Marek L, Schmetter R, Kuna K, Hamacher A, Mordmüller B, Kassack MU, Winzeler EA, Avery VM, Andrews KT, Kurz T.
Eur J Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.ejmech.2014.05.050Using genetic methods to define the targets of compounds with antimalarial activity.
Flannery EL, Fidock DA, Winzeler EA.
J Med Chem · research support, non-u.s. gov't; research-article; review; journal article; research support, n.i.h., extramural · DOI 10.1021/jm400325jApproaches to protozoan drug discovery: phenotypic screening.
Sykes ML, Avery VM.
J Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1021/jm4004279Effects of antimalarial molecules on the gametocyte stage of Plasmodium falciparum: the debate.
Dechy-Cabaret O, Benoit-Vical F.
J Med Chem · journal article · DOI 10.1021/jm3005898In vivo and in vitro efficacy of chloroquine against Plasmodium malariae and P. ovale in Papua, Indonesia.
Siswantoro H, Russell B, Ratcliff A, Prasetyorini B, Chalfein F, Marfurt J, Kenangalem E, Wuwung M, Piera KA, Ebsworth EP, Anstey NM, Tjitra E, Price RN.
Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/aac.01122-10In vitro activity of pyronaridine against multidrug-resistant Plasmodium falciparum and Plasmodium vivax.
Price RN, Marfurt J, Chalfein F, Kenangalem E, Piera KA, Tjitra E, Anstey NM, Russell B.
Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/aac.00801-10Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Prado-Prado FJ, García-Mera X, González-Díaz H.
Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2010.01.068Pyronaridine, a novel modulator of P-glycoprotein-mediated multidrug resistance in tumor cells in vitro and in vivo.
Qi J, Wang S, Liu G, Peng H, Wang J, Zhu Z, Yang C.
Biochem Biophys Res Commun · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bbrc.2004.05.099Synthesis and in vitro evaluation of 9-anilino-3,6-diaminoacridines active against a multidrug-resistant strain of the malaria parasite Plasmodium falciparum.
Gamage SA, Tepsiri N, Wilairat P, Wojcik SJ, Figgitt DP, Ralph RK, Denny WA.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00036a014