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Publications in the selection

15 hits

Bibliografisk träff 2022-02-18

Synthesis and Evaluation of Novel Tetrahydronaphthyridine CXCR4 Antagonists with Improved Drug-like Profiles.

Jecs E, Tahirovic YA, Wilson RJ, Miller EJ, Kim M, Truax V, Nguyen HH, Akins NS, Saindane M, Wang T, Sum CS, Cvijic ME, Schroeder GM, Burton SL, Derdeyn CA, Xu L, Jiang Y, Wilson LJ, Liotta DC.

J Med Chem · research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/acs.jmedchem.1c01564

Bibliografisk träff 2021-10-04

Amino-Heterocycle Tetrahydroisoquinoline CXCR4 Antagonists with Improved ADME Profiles via Late-Stage Buchwald Couplings.

Nguyen HH, Tahirovic YA, Truax VM, Wilson RJ, Jecs E, Miller EJ, Kim MB, Akins NS, Xu L, Jiang Y, Wang T, Sum CS, Cvijic ME, Schroeder GM, Wilson LJ, Liotta DC.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/acsmedchemlett.1c00449

Bibliografisk träff 2020-07-23

Design, synthesis, and evaluation of pyrrolidine based CXCR4 antagonists with in vivo anti-tumor metastatic activity.

Li Z, Wang X, Lin Y, Wang Y, Wu S, Xia K, Xu C, Ma H, Zheng J, Luo L, Zhu F, He S, Zhang X.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2020.112537

Bibliografisk träff 2018-04-09

Discovery of <i>N</i>-Alkyl Piperazine Side Chain Based CXCR4 Antagonists with Improved Drug-like Properties.

Tahirovic YA, Truax VM, Wilson RJ, Jecs E, Nguyen HH, Miller EJ, Kim MB, Kuo KM, Wang T, Sum CS, Cvijic ME, Schroeder GM, Wilson LJ, Liotta DC.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/acsmedchemlett.8b00030

Bibliografisk träff 2018-01-30

Discovery of Tetrahydroisoquinoline-Containing CXCR4 Antagonists with Improved in Vitro ADMET Properties.

Miller EJ, Jecs E, Truax VM, Katzman BM, Tahirovic YA, Wilson RJ, Kuo KM, Kim MB, Nguyen HH, Saindane MT, Zhao H, Wang T, Sum CS, Cvijic ME, Schroeder GM, Wilson LJ, Liotta DC.

J Med Chem · research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/acs.jmedchem.7b01420

Bibliografisk träff 2017-03-10

Structural Analysis of Chemokine Receptor-Ligand Interactions.

Arimont M, Sun SL, Leurs R, Smit M, de Esch IJP, de Graaf C.

J Med Chem · research support, non-u.s. gov't; review-article; review; journal article · DOI 10.1021/acs.jmedchem.6b01309

Bibliografisk träff 2015-04-17

Discovery of novel N-aryl piperazine CXCR4 antagonists.

Zhao H, Prosser AR, Liotta DC, Wilson LJ.

Bioorg Med Chem Lett · research-article; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1016/j.bmcl.2015.04.036

Bibliografisk träff 2013-09-05

Discovery of tetrahydroisoquinoline-based CXCR4 antagonists.

Truax VM, Zhao H, Katzman BM, Prosser AR, Alcaraz AA, Saindane MT, Howard RB, Culver D, Arrendale RF, Gruddanti PR, Evers TJ, Natchus MG, Snyder JP, Liotta DC, Wilson LJ.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/ml400183q

Bibliografisk träff 2011-01-11

Design of novel CXCR4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication.

Skerlj R, Bridger G, McEachern E, Harwig C, Smith C, Kaller A, Veale D, Yee H, Skupinska K, Wauthy R, Wang L, Baird I, Zhu Y, Burrage K, Yang W, Sartori M, Huskens D, De Clercq E, Schols D.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2011.01.021

Bibliografisk träff 2010-05-01

Synthesis and SAR of novel isoquinoline CXCR4 antagonists with potent anti-HIV activity.

Miller JF, Gudmundsson KS, D'Aurora Richardson L, Jenkinson S, Spaltenstein A, Thomson M, Wheelan P.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2010.03.118

Bibliografisk träff 2010-04-01

Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication.

Skerlj RT, Bridger GJ, Kaller A, McEachern EJ, Crawford JB, Zhou Y, Atsma B, Langille J, Nan S, Veale D, Wilson T, Harwig C, Hatse S, Princen K, De Clercq E, Schols D.

J Med Chem · journal article · DOI 10.1021/jm100073m

Bibliografisk träff 2009-07-10

Amine substituted N-(1H-benzimidazol-2ylmethyl)-5,6,7,8-tetrahydro-8-quinolinamines as CXCR4 antagonists with potent activity against HIV-1.

Gudmundsson KS, Sebahar PR, Richardson LD, Miller JF, Turner EM, Catalano JG, Spaltenstein A, Lawrence W, Thomson M, Jenkinson S.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2009.07.037

Bibliografisk träff 2009-05-18

The novel CXCR4 antagonist KRH-3955 is an orally bioavailable and extremely potent inhibitor of human immunodeficiency virus type 1 infection: comparative studies with AMD3100.

Murakami T, Kumakura S, Yamazaki T, Tanaka R, Hamatake M, Okuma K, Huang W, Toma J, Komano J, Yanaka M, Tanaka Y, Yamamoto N.

Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/aac.01727-08

Bibliografisk träff 2008-02-19

Effect of low-dose ritonavir on the pharmacokinetics of the CXCR4 antagonist AMD070 in healthy volunteers.

Cao YJ, Flexner CW, Dunaway S, Park JG, Klingman K, Wiggins I, Conley J, Radebaugh C, Kashuba AD, MacFarland R, Becker S, Hendrix CW.

Antimicrob Agents Chemother · research-article; clinical trial, phase i; journal article; research support, n.i.h., extramural · DOI 10.1128/aac.01460-07

Bibliografisk träff 2007-04-23

Multiple-dose escalation study of the safety, pharmacokinetics, and biologic activity of oral AMD070, a selective CXCR4 receptor inhibitor, in human subjects.

Stone ND, Dunaway SB, Flexner C, Tierney C, Calandra GB, Becker S, Cao YJ, Wiggins IP, Conley J, MacFarland RT, Park JG, Lalama C, Snyder S, Kallungal B, Klingman KL, Hendrix CW.

Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; multicenter study; clinical trial, phase i; journal article; research support, n.i.h., extramural · DOI 10.1128/aac.00013-07