A comprehensive in vitro and in vivo metabolism study of hydroxysafflor yellow A.
Wu L, Tang Y, Shan C, Chai C, Zhou Z, Shi X, Ding N, Wang J, Lin L, Tan R.
J Mass Spectrom · journal article · DOI 10.1002/jms.4041 PUBLICATION REGISTRY
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28 hitsSolid lipid nanoparticles as carriers for oral delivery of hydroxysafflor yellow A.
Zhao B, Gu S, Du Y, Shen M, Liu X, Shen Y.
Int J Pharm · journal article · DOI 10.1016/j.ijpharm.2017.10.040The potential mechanism for Hydroxysafflor yellow A attenuating blood-brain barrier dysfunction via tight junction signaling pathways excavated by an integrated serial affinity chromatography and shotgun proteomics analysis approach.
Lv Y, Fu L.
Neurochem Int · research support, non-u.s. gov't; journal article · DOI 10.1016/j.neuint.2017.10.012Hydroxysafflor Yellow A Attenuates the Apoptosis of Peripheral Blood CD4<sup>+</sup> T Lymphocytes in a Murine Model of Sepsis.
Wang J, Wang P, Gui S, Li Y, Chen R, Zeng R, Zhao P, Wu H, Huang Z, Wu J.
Front Pharmacol · research-article; journal article · DOI 10.3389/fphar.2017.00613[Pharmacokinetics-pharmacodynamics correlation of protocatechuic aldehyde and hydroxysafflor yellow A alone or their combination use in rats with hyperlipidemia].
Fan HJ, Yu L, Jin WF, Li M, Zhou J, Li XH, Zhang YY.
Zhongguo Zhong Yao Za Zhi · journal article · DOI 10.19540/j.cnki.cjcmm.20170523.008Hydroxysafflor Yellow A Suppresses MRC-5 Cell Activation Induced by TGF-β1 by Blocking TGF-β1 Binding to TβRII.
Pan R, Zhang Y, Zheng M, Zang B, Jin M.
Front Pharmacol · research-article; journal article · DOI 10.3389/fphar.2017.00264HSYA alleviates secondary neuronal death through attenuating oxidative stress, inflammatory response, and neural apoptosis in SD rat spinal cord compression injury.
Pei JP, Fan LH, Nan K, Li J, Dang XQ, Wang KZ.
J Neuroinflammation · research support, non-u.s. gov't; research-article; journal article · DOI 10.1186/s12974-017-0870-1Molecular dynamics simulation integrating the inhibition kinetics of hydroxysafflor yellow A on α-glucosidase.
Xu Y, Lee J, Park YD, Yang JM, Zheng J, Zhang Q.
J Biomol Struct Dyn · journal article · DOI 10.1080/07391102.2017.1300544Hydroxysafflor yellow A promotes neovascularization and cardiac function recovery through HO-1/VEGF-A/SDF-1α cascade.
Wei G, Yin Y, Duan J, Guo C, Zhu Y, Wang Y, Xi M, Wen A.
Biomed Pharmacother · journal article · DOI 10.1016/j.biopha.2017.01.074Hydroxysafflor Yellow A Improves Motor Dysfunction in the Rotenone-Induced Mice Model of Parkinson's Disease.
Wang T, Wang L, Li C, Han B, Wang Z, Li J, Lv Y, Wang S, Fu F.
Neurochem Res · journal article · DOI 10.1007/s11064-017-2176-1ROS-Dependent Activation of Autophagy through the PI3K/Akt/mTOR Pathway Is Induced by Hydroxysafflor Yellow A-Sonodynamic Therapy in THP-1 Macrophages.
Jiang Y, Kou J, Han X, Li X, Zhong Z, Liu Z, Zheng Y, Tian Y, Yang L.
Oxid Med Cell Longev · research-article; journal article · DOI 10.1155/2017/8519169Hydroxysafflor yellow A attenuates the expression of inflammatory cytokines in acute soft tissue injury.
Dong F, Xue C, Wang Y, Peng Y, Zhang Y, Jin M, Zang B.
Sci Rep · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/srep40584Hydroxysafflor yellow A cardioprotection in ischemia-reperfusion (I/R) injury mainly via Akt/hexokinase II independent of ERK/GSK-3β pathway.
Min J, Wei C.
Biomed Pharmacother · journal article · DOI 10.1016/j.biopha.2016.12.113Hydroxysafflor Yellow A Alleviates Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome in Mice.
Zhang Y, Song L, Pan R, Gao J, Zang BX, Jin M.
Biol Pharm Bull · journal article · DOI 10.1248/bpb.b16-00329The Role of E-Cadherin/β-Catenin in Hydroxysafflor Yellow A Inhibiting Adhesion, Invasion, Migration and Lung Metastasis of Hepatoma Cells.
Ma L, Liu L, Ma Y, Xie H, Yu X, Wang X, Fan A, Ge D, Xu Y, Zhang Q, Song C.
Biol Pharm Bull · journal article · DOI 10.1248/bpb.b17-00281Hydroxysafflor Yellow A Promotes Angiogenesis via the Angiopoietin 1/ Tie-2 Signaling Pathway.
Chen T, Chen N, Pang N, Xiao L, Li Y, Li R, Luo M, Deng X, Ren M, Wu J, Wang L.
J Vasc Res · research support, non-u.s. gov't; journal article · DOI 10.1159/000452408Restorative effects of hydroxysafflor yellow A on hepatic function in an experimental regression model of hepatic fibrosis induced by carbon tetrachloride.
Li Y, Shi Y, Sun Y, Liu L, Bai X, Wang D, Li H.
Mol Med Rep · research-article; journal article · DOI 10.3892/mmr.2016.5965Hydroxysafflor yellow A inhibits IL-1β-induced release of IL-6, IL-8, and MMP-1 via suppression of ERK, NF-κB and AP-1 signaling in SW982 human synovial cells.
Cheng BF, Gao YX, Lian JJ, Guo DD, Wang L, Wang M, Yang HJ, Feng ZW.
Food Funct · journal article · DOI 10.1039/c6fo01045hHydroxysafflor yellow A alleviates myocardial ischemia/reperfusion in hyperlipidemic animals through the suppression of TLR4 signaling.
Han D, Wei J, Zhang R, Ma W, Shen C, Feng Y, Xia N, Xu D, Cai D, Li Y, Fang W.
Sci Rep · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/srep35319Hydroxysafflor yellow A exerts antioxidant effects in a rat model of traumatic brain injury.
Wang Y, Zhang C, Peng W, Xia Z, Gan P, Huang W, Shi Y, Fan R.
Mol Med Rep · research-article; journal article · DOI 10.3892/mmr.2016.5720Hydroxysafflor yellow A inhibits TGF-β1-induced activation of human fetal lung fibroblasts in vitro.
Pan R, Zhang Y, Zang B, Tan L, Jin M.
J Pharm Pharmacol · journal article · DOI 10.1111/jphp.12596Synergistic cardioprotective effects of Danshensu and hydroxysafflor yellow A against myocardial ischemia-reperfusion injury are mediated through the Akt/Nrf2/HO-1 pathway.
Hu T, Wei G, Xi M, Yan J, Wu X, Wang Y, Zhu Y, Wang C, Wen A.
Int J Mol Med · research-article; journal article · DOI 10.3892/ijmm.2016.2584Hydroxysafflor yellow A increases BDNF and NMDARs in the hippocampus in a vascular dementia rat model.
Xing M, Sun Q, Wang Y, Cheng Y, Zhang N.
Brain Res · research support, non-u.s. gov't; journal article · DOI 10.1016/j.brainres.2016.04.030Hydroxysafflor yellow A (HSYA) attenuates hypoxic pulmonary arterial remodelling and reverses right ventricular hypertrophy in rats.
Li L, Dong P, Hou C, Cao F, Sun S, He F, Song Y, Li S, Bai Y, Zhu D.
J Ethnopharmacol · journal article · DOI 10.1016/j.jep.2016.04.004Hydroxysafflor Yellow A Attenuates Bleomycin-induced Pulmonary Fibrosis in Mice.
Jin M, Wu Y, Wang L, Zang B, Tan L.
Phytother Res · research support, non-u.s. gov't; journal article · DOI 10.1002/ptr.5560Hydroxysafflor Yellow A Attenuates Neuron Damage by Suppressing the Lipopolysaccharide-Induced TLR4 Pathway in Activated Microglial Cells.
Lv Y, Qian Y, Ou-Yang A, Fu L.
Cell Mol Neurobiol · research-article; journal article · DOI 10.1007/s10571-015-0322-3Hydroxysafflor yellow A exerts neuroprotective effects in cerebral ischemia reperfusion-injured mice by suppressing the innate immune TLR4-inducing pathway.
Lv Y, Qian Y, Fu L, Chen X, Zhong H, Wei X.
Eur J Pharmacol · journal article · DOI 10.1016/j.ejphar.2015.11.036Protective effects of hydroxysafflor yellow A (HSYA) on alcohol-induced liver injury in rats.
He Y, Liu Q, Li Y, Yang X, Wang W, Li T, Zhang W, Cui Y, Wang C, Lin R.
J Physiol Biochem · research support, non-u.s. gov't; journal article · DOI 10.1007/s13105-015-0382-3