The N-demethylation of the doxepin isomers is mainly catalyzed by the polymorphic CYP2C19.
Härtter S, Tybring G, Friedberg T, Weigmann H, Hiemke C.
Pharm Res · research support, non-u.s. gov't; journal article · DOI 10.1023/a:1016478708902 PUBLICATION REGISTRY
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Publikationer som ChEBI hänvisar till för (E)-desmethyldoxepin. Visa hela publikationsregistret
A publication hit is not a conclusion. Publikationslistan visar bibliografiska uppgifter. Eventuella forskningsutdrag visas separat med originalunderlag. En källhänvisning visar inte i sig effekt, dosering eller säkerhet.
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4 hitsQuantitative determination of E- and Z-doxepin and E- and Z-desmethyldoxepin by high-performance liquid chromatography.
Adamczyk M, Fishpaugh JR, Harrington C.
Ther Drug Monit · journal article · DOI 10.1097/00007691-199508000-00010Geometric isomerization of doxepin during its N-demethylation in humans.
Ghabrial H, Prakash C, Tacke UG, Blair IA, Wilkinson GR.
Drug Metab Dispos · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1016/s0090-9556(25)07194-6Plasma levels of the cis- and trans-isomers of doxepin and desmethyldoxepin after administration of doxepin to patients.
Bogaert MG, Rosseel MT, Deberdt R, Vranckx C.
Arzneimittelforschung · journal article