Neosaxitoxin Inhibits the Expression of Inflammation Markers of the M1 Phenotype in Macrophages.
Montero MC, Del Campo M, Bono M, Simon MV, Guerrero J, Lagos N.
Mar Drugs · research-article; journal article · DOI 10.3390/md18060283 PUBLICATION REGISTRY
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13 hitsIn vivo blockade of ovarian sympathetic activity by Neosaxitoxin prevents polycystic ovary in rats.
Del Campo M, Lagos N, Lara H.
J Endocrinol · research support, non-u.s. gov't; journal article · DOI 10.1530/joe-19-0545Improved Accuracy of Saxitoxin Measurement Using an Optimized Enzyme-Linked Immunosorbent Assay.
McCall JR, Holland WC, Keeler DM, Hardison DR, Litaker RW.
Toxins (Basel) · research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.3390/toxins11110632Evaluation of Neosaxitoxin as a local anesthetic during piglet castration: A potential alternative for Lidocaine.
Valenzuela C, Torres C, Muñoz V, Simbaina JC, Sánchez A, Bustamante T, Sepúlveda JM, Piron R, Del Campo M, Lagos N.
Toxicon · journal article; clinical trial, veterinary · DOI 10.1016/j.toxicon.2019.03.021Long-lasting, reversible and non-neurotoxic inactivation of hippocampus activity induced by neosaxitoxin.
Galindo J, Contreras M, Maldonado P, Torrealba F, Lagos N, Valdés JL.
J Neurosci Methods · research support, non-u.s. gov't; journal article · DOI 10.1016/j.jneumeth.2018.08.013Neosaxitoxin, a Paralytic Shellfish Poison toxin, effectively manages bucked shins pain, as a local long-acting pain blocker in an equine model.
Riquelme G, Sepúlveda JM, Al Ghumgham Z, Del Campo M, Montero C, Lagos N.
Toxicon · journal article · DOI 10.1016/j.toxicon.2017.11.004Measurement of neosaxitoxin in human plasma using liquid-chromatography tandem mass spectrometry: Proof of concept for a pharmacokinetic application.
Peake RW, Zhang VY, Azcue N, Hartigan CE, Shkreta A, Prabhakara J, Berde CB, Kellogg MD.
J Chromatogr B Analyt Technol Biomed Life Sci · validation study; clinical trial, phase i; journal article · DOI 10.1016/j.jchromb.2016.09.043A Phase 1, Dose-escalation, Double-blind, Block-randomized, Controlled Trial of Safety and Efficacy of Neosaxitoxin Alone and in Combination with 0.2% Bupivacaine, with and without Epinephrine, for Cutaneous Anesthesia.
Lobo K, Donado C, Cornelissen L, Kim J, Ortiz R, Peake RW, Kellogg M, Alexander ME, Zurakowski D, Kurgansky KE, Peyton J, Bilge A, Boretsky K, McCann ME, Berde CB, Cravero J.
Anesthesiology · research support, non-u.s. gov't; clinical trial, phase i; randomized controlled trial; journal article · DOI 10.1097/aln.0000000000000831Neosaxitoxin in Rat Sciatic Block: Improved Therapeutic Index Using Combinations with Bupivacaine, with and without Epinephrine.
Templin JS, Wylie MC, Kim JD, Kurgansky KE, Gorski G, Kheir J, Zurakowski D, Corfas G, Berde C.
Anesthesiology · research support, non-u.s. gov't; journal article · DOI 10.1097/aln.0000000000000832Neosaxitoxin versus Traditional Local Anesthetics: Mechanism of Action and Sites of Notable Effect.
Rathmell JP, Strichartz G, Wanderer J.
Anesthesiology · comparative study; journal article · DOI 10.1097/01.anes.0000470956.02665.a6Chronic toxicity study of neosaxitoxin in rats.
Zepeda RJ, Candiracci M, Lobos N, Lux S, Miranda HF.
Mar Drugs · research support, non-u.s. gov't; research-article; journal article · DOI 10.3390/md12095055Biosynthetic intermediate analysis and functional homology reveal a saxitoxin gene cluster in cyanobacteria.
Kellmann R, Mihali TK, Jeon YJ, Pickford R, Pomati F, Neilan BA.
Appl Environ Microbiol · research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/aem.00353-08Active groups of saxitoxin and tetrodotoxin as deduced from actions of saxitoxin analogues on frog muscle and squid axon.
Kao CY, Walker SE.
J Physiol · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1113/jphysiol.1982.sp014095