Is PF-00835231 a Pan-SARS-CoV-2 Mpro Inhibitor? A Comparative Study.
Baig MH, Sharma T, Ahmad I, Abohashrh M, Alam MM, Dong JJ.
Molecules · comparative study; research-article; journal article · DOI 10.3390/molecules26061678 PUBLICATION REGISTRY
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5 hitsA comparative analysis of SARS-CoV-2 antivirals characterizes 3CL<sup>pro</sup> inhibitor PF-00835231 as a potential new treatment for COVID-19.
de Vries M, Mohamed AS, Prescott RA, Valero-Jimenez AM, Desvignes L, O'Connor R, Steppan C, Devlin JC, Ivanova E, Herrera A, Schinlever A, Loose P, Ruggles K, Koralov SB, Anderson AS, Binder J, Dittmann M.
J Virol · research-article; journal article · DOI 10.1128/jvi.01819-20Dual inhibition of SARS-CoV-2 and human rhinovirus with protease inhibitors in clinical development.
Liu C, Boland S, Scholle MD, Bardiot D, Marchand A, Chaltin P, Blatt LM, Beigelman L, Symons JA, Raboisson P, Gurard-Levin ZA, Vandyck K, Deval J.
Antiviral Res · research support, non-u.s. gov't; research-article; journal article · DOI 10.1016/j.antiviral.2021.105020Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19.
Hoffman RL, Kania RS, Brothers MA, Davies JF, Ferre RA, Gajiwala KS, He M, Hogan RJ, Kozminski K, Li LY, Lockner JW, Lou J, Marra MT, Mitchell LJ, Murray BW, Nieman JA, Noell S, Planken SP, Rowe T, Ryan K, Smith GJ, Solowiej JE, Steppan CM, Taggart B.
J Med Chem · journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.0c01063α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment.
Zhang L, Lin D, Kusov Y, Nian Y, Ma Q, Wang J, von Brunn A, Leyssen P, Lanko K, Neyts J, de Wilde A, Snijder EJ, Liu H, Hilgenfeld R.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.9b01828