Menin‑MLL inhibitors induce ferroptosis and enhance the anti‑proliferative activity of auranofin in several types of cancer cells.
Kato I, Kasukabe T, Kumakura S.
Int J Oncol · journal article · DOI 10.3892/ijo.2020.5116 PUBLICATION REGISTRY
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14 hitsNovel 15-Lipoxygenase-1 Inhibitor Protects Macrophages from Lipopolysaccharide-Induced Cytotoxicity.
Guo H, Verhoek IC, Prins GGH, van der Vlag R, van der Wouden PE, van Merkerk R, Quax WJ, Olinga P, Hirsch AKH, Dekker FJ.
J Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/acs.jmedchem.9b00212Pharmacological inhibition of arachidonate 15-lipoxygenase protects human spermatozoa against oxidative stress.
Walters JLH, De Iuliis GN, Dun MD, Aitken RJ, McLaughlin EA, Nixon B, Bromfield EG.
Biol Reprod · research support, non-u.s. gov't; journal article · DOI 10.1093/biolre/ioy058Design of a novel thiophene inhibitor of 15-lipoxygenase-1 with both anti-inflammatory and neuroprotective properties.
Eleftheriadis N, Poelman H, Leus NGJ, Honrath B, Neochoritis CG, Dolga A, Dömling A, Dekker FJ.
Eur J Med Chem · research-article; journal article · DOI 10.1016/j.ejmech.2016.07.01012/15-Lipoxygenase Inhibition Reverses Cognitive Impairment, Brain Amyloidosis, and Tau Pathology by Stimulating Autophagy in Aged Triple Transgenic Mice.
Di Meco A, Li JG, Blass BE, Abou-Gharbia M, Lauretti E, Praticò D.
Biol Psychiatry · research support, non-u.s. gov't; journal article · DOI 10.1016/j.biopsych.2016.05.023Rational Development of a Potent 15-Lipoxygenase-1 Inhibitor with in Vitro and ex Vivo Anti-inflammatory Properties.
Eleftheriadis N, Neochoritis CG, Leus NG, van der Wouden PE, Dömling A, Dekker FJ.
J Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.5b0112115-Lipoxygenases regulate the production of chemokines in human lung macrophages.
Abrial C, Grassin-Delyle S, Salvator H, Brollo M, Naline E, Devillier P.
Br J Pharmacol · research-article; journal article · DOI 10.1111/bph.13210Pharmacologic blockade of 12/15-lipoxygenase ameliorates memory deficits, Aβ and tau neuropathology in the triple-transgenic mice.
Chu J, Li JG, Giannopoulos PF, Blass BE, Childers W, Abou-Gharbia M, Praticò D.
Mol Psychiatry · research support, non-u.s. gov't; journal article · DOI 10.1038/mp.2014.170Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia.
Gregus AM, Dumlao DS, Wei SC, Norris PC, Catella LC, Meyerstein FG, Buczynski MW, Steinauer JJ, Fitzsimmons BL, Yaksh TL, Dennis EA.
FASEB J · research-article; journal article; research support, n.i.h., extramural · DOI 10.1096/fj.12-217414Arachidonic acid epoxygenase and 12(S)-lipoxygenase: evidence of their concerted involvement in ductus arteriosus constriction to oxygen.
Baragatti B, Coceani F.
Can J Physiol Pharmacol · research support, non-u.s. gov't; journal article · DOI 10.1139/y11-025Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti.
Deng S, Palu 'K, West BJ, Su CX, Zhou BN, Jensen JC.
J Nat Prod · journal article · DOI 10.1021/np0605539Tryptamine and homotryptamine-based sulfonamides as potent and selective inhibitors of 15-lipoxygenase.
Weinstein DS, Liu W, Gu Z, Langevine C, Ngu K, Fadnis L, Combs DW, Sitkoff D, Ahmad S, Zhuang S, Chen X, Wang FL, Loughney DA, Atwal KS, Zahler R, Macor JE, Madsen CS, Murugesan N.
Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2004.12.081A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit.
Bocan TM, Rosebury WS, Mueller SB, Kuchera S, Welch K, Daugherty A, Cornicelli JA.
Atherosclerosis · journal article · DOI 10.1016/s0021-9150(97)00204-9Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties.
Sendobry SM, Cornicelli JA, Welch K, Bocan T, Tait B, Trivedi BK, Colbry N, Dyer RD, Feinmark SJ, Daugherty A.
Br J Pharmacol · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/sj.bjp.0701007